nlpI

Summary

Gene Symbol: nlpI
Description: lipoprotein involved in osmotic sensitivity and filamentation
Alias: ECK3151, JW3132, yhbM
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Wilson C, Kajander T, Regan L. The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold. FEBS J. 2005;272:166-79 pubmed
    ..Here we present the high-resolution structure of NlpI, the first structure of a complete TPR-containing protein...
  2. McBroom A, Johnson A, Vemulapalli S, Kuehn M. Outer membrane vesicle production by Escherichia coli is independent of membrane instability. J Bacteriol. 2006;188:5385-92 pubmed
    ..Detergent sensitivity, leakiness, and growth characteristics of the novel vesiculation mutant strains did not correlate with vesiculation levels, demonstrating that vesicle production is not predictive of envelope instability. ..
  3. Bylund G, Lövgren J, Wikström P. Characterization of mutations in the metY-nusA-infB operon that suppress the slow growth of a DeltarimM mutant. J Bacteriol. 2001;183:6095-106 pubmed
    ..new promoter for rbfA; and one was a duplication, placing a second copy of rbfA downstream from a promoter for the yhbM gene...
  4. Tadokoro A, Hayashi H, Kishimoto T, Makino Y, Fujisaki S, Nishimura Y. Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease. J Biochem. 2004;135:185-91 pubmed
    Escherichia coli spr (suppressor of prc) mutants and nlpI mutants show thermosensitive growth. The thermosensitivity of the spr mutants was suppressed by the nlpI mutations...
  5. Barnich N, Bringer M, Claret L, Darfeuille Michaud A. Involvement of lipoprotein NlpI in the virulence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease. Infect Immun. 2004;72:2484-93 pubmed
    ..selected for its impaired ability to invade epithelial cells had an insertion of a Tn phoA transposon within the nlpI gene encoding the lipoprotein NlpI...
  6. Sanchez Torres V, Maeda T, Wood T. Global regulator H-NS and lipoprotein NlpI influence production of extracellular DNA in Escherichia coli. Biochem Biophys Res Commun. 2010;401:197-202 pubmed publisher
    ..Deleting nlpI, yfeC, and rna increased eDNA from planktonic cultures while deleting hns and rfaD decreased eDNA production...
  7. Tao J, Sang Y, Teng Q, Ni J, Yang Y, Tsui S, et al. Heat shock proteins IbpA and IbpB are required for NlpI-participated cell division in Escherichia coli. Front Microbiol. 2015;6:51 pubmed publisher
    Lipoprotein NlpI of Escherichia coli is involved in the cell division, virulence, and bacterial interaction with eukaryotic host cells...
  8. Toone W, Rudd K, Friesen J. deaD, a new Escherichia coli gene encoding a presumed ATP-dependent RNA helicase, can suppress a mutation in rpsB, the gene encoding ribosomal protein S2. J Bacteriol. 1991;173:3291-302 pubmed
    ..We suggest that the DeaD protein plays a hitherto unknown role in translation in E. coli...
  9. R gnier P, Grunberg Manago M, Portier C. Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase. Homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1. J Biol Chem. 1987;262:63-8 pubmed
    ..The possibility that this 69-amino-acid stretch constitutes the polynucleotide binding domain of polynucleotide phosphorylase is discussed...

More Information

Publications12

  1. Ohara M, Wu H, Sankaran K, Rick P. Identification and characterization of a new lipoprotein, NlpI, in Escherichia coli K-12. J Bacteriol. 1999;181:4318-25 pubmed
    We report here the identification of a new lipoprotein, NlpI, in Escherichia coli K-12. The NlpI structural gene (nlpI) is located between the genes pnp (polynucleotide phosphorylase) and deaD (RNA helicase) at 71 min on the E...
  2. McBroom A, Kuehn M. Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. Mol Microbiol. 2007;63:545-58 pubmed
    ..In addition to identifying a novel mechanism for alleviating stress, this work provides physiological relevance for vesicle production as a protective mechanism. ..
  3. Singh S, Parveen S, SaiSree L, Reddy M. Regulated proteolysis of a cross-link-specific peptidoglycan hydrolase contributes to bacterial morphogenesis. Proc Natl Acad Sci U S A. 2015;112:10956-61 pubmed publisher
    ..that MepS is rapidly degraded by a proteolytic system comprising an outer membrane lipoprotein of unknown function, NlpI, and a periplasmic protease, Prc (or Tsp)...