Gene Symbol: nanC
Description: N-acetylnuraminic acid outer membrane channel protein
Alias: ECK4302, JW5778, yjhA
Species: Escherichia coli str. K-12 substr. MG1655
Vimr E, Kalivoda K, Deszo E, Steenbergen S. Diversity of microbial sialic acid metabolism. Microbiol Mol Biol Rev. 2004;68:132-53 pubmed
..Sialic acid is, therefore, a host molecule to be copied (molecular mimicry), eaten (nutrition), and interpreted (cell signaling) by diverse metabolic machinery in all major groups of mammalian pathogens and commensals. ..
Signorell G, Chami M, Condemine G, Schenk A, Philippsen A, Engel A, et al
. Projection maps of three members of the KdgM outer membrane protein family. J Struct Biol. 2007;160:395-403 pubmed
We present the projection structures of the three outer membrane porins KdgM and KdgN from Erwinia chrysanthemi and NanC from Escherichia coli, based on 2D electron crystallography...
Condemine G, Berrier C, Plumbridge J, Ghazi A. Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. J Bacteriol. 2005;187:1959-65 pubmed
The Escherichia coli yjhA (renamed nanC) gene encodes a protein of the KdgM family of outer membrane-specific channels...
Wirth C, Condemine G, Boiteux C, Berneche S, Schirmer T, Peneff C. NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. J Mol Biol. 2009;394:718-31 pubmed publisher
..N-Acetylneuraminic acid, the most abundant sialic acid, can enter into Escherichia coli K12 through NanC, an N-acetylneuraminic acid-inducible outer-membrane channel...
El Labany S, Sohanpal B, Lahooti M, Akerman R, Blomfield I. Distant cis-active sequences and sialic acid control the expression of fimB in Escherichia coli K-12. Mol Microbiol. 2003;49:1109-18 pubmed
..2 apparently control fimB expression by an antirepression mechanism that involves additional sequences proximal to yjhA. Region 1 encompasses a 27 bp DNA sequence conserved upstream of genes known (nanAT ) or suspected (yjhBC) to be ..
Severi E, Muller A, Potts J, Leech A, Williamson D, Wilson K, et al
. Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT. J Biol Chem. 2008;283:4841-9 pubmed
..We also present data suggesting that the ability to utilize alpha-N-acetylneuraminic acid released from complex sialoconjugates in vivo provides a physiological advantage to bacteria containing YjhT. ..