mutY

Summary

Gene Symbol: mutY
Description: adenine DNA glycosylase
Alias: ECK2956, JW2928, micA, mutB
Species: Escherichia coli str. K-12 substr. MG1655
Products:     mutY

Top Publications

  1. Aiub C, Mazzei J, Pinto L, Felzenszwalb I. Participation of BER and NER pathways in the repair of DNA lesions induced at low N-nitrosodiethylamine concentrations. Toxicol Lett. 2004;154:133-42 pubmed
    ..and double Escherichia coli DNA repair mutants (uvrA, uvrB, uvrC, fpg, nth, xthA, fpg/nth, uvrA/fpg, fpg/xthA, mutY, and fpg/mutY), using pre-incubation periods of 90 min...
  2. Chmiel N, Golinelli M, Francis A, David S. Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain. Nucleic Acids Res. 2001;29:553-64 pubmed
    The Escherichia coli DNA repair enzyme MutY plays an important role in the prevention of DNA mutations by removing misincorporated adenine residues from 7, 8-dihydro-8-oxo-2'-deoxyguanosine:2'-deoxyadenosine (OG:A) mispairs...
  3. Manuel R, Hitomi K, Arvai A, House P, Kurtz A, Dodson M, et al. Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase. J Biol Chem. 2004;279:46930-9 pubmed
    The Escherichia coli adenine DNA glycosylase, MutY, plays an important role in the maintenance of genomic stability by catalyzing the removal of adenine opposite 8-oxo-7,8-dihydroguanine or guanine in duplex DNA...
  4. Kim M, Huang T, Miller J. Competition between MutY and mismatch repair at A x C mispairs In vivo. J Bacteriol. 2003;185:4626-9 pubmed
    We show that the MutY protein competes with the MutS-dependent mismatch repair system to process at least some A. C mispairs in vivo, converting them to G. C pairs...
  5. Lu A, Bai H, Shi G, Chang D. MutY and MutY homologs (MYH) in genome maintenance. Front Biosci. 2006;11:3062-80 pubmed
    The base excision repair carried out by bacterial MutY DNA glycosylase and eukaryotic MutY homolog (MYH) is responsible for removing adenines misincorporated into DNA opposite G and 7,8-dihydro-8-oxo-guanines (8-oxoG); thereby preventing ..
  6. Li X, Wright P, Lu A. The C-terminal domain of MutY glycosylase determines the 7,8-dihydro-8-oxo-guanine specificity and is crucial for mutation avoidance. J Biol Chem. 2000;275:8448-55 pubmed
    Escherichia coli MutY is an adenine DNA glycosylase active on DNA substrates containing A/G, A/8-oxoG, or A/C mismatches and also has a weak guanine glycosylase activity on G/8-oxoG-containing DNA...
  7. Bulychev N, Varaprasad C, Dorman G, Miller J, Eisenberg M, Grollman A, et al. Substrate specificity of Escherichia coli MutY protein. Biochemistry. 1996;35:13147-56 pubmed
    The MutY protein of Escherichia coli removes mismatched deoxyadenine residues from DNA. In this study, duplex oligodeoxynucleotides containing modified bases are used as model substrates for this enzyme...
  8. Cox E, Gibson T. Selection for high mutation rates in chemostats. Genetics. 1974;77:169-84 pubmed
    ..Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density. ..
  9. Francis A, David S. Escherichia coli MutY and Fpg utilize a processive mechanism for target location. Biochemistry. 2003;42:801-10 pubmed
    b>MutY and formamidopyrimidine-DNA-glycosylase (Fpg) are base-excision repair (BER) enzymes involved in the 8-oxoguanine repair pathway in Escherichia coli...

More Information

Publications69

  1. Nghiem Y, Cabrera M, Cupples C, Miller J. The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions. Proc Natl Acad Sci U S A. 1988;85:2709-13 pubmed
    ..The locus responsible for the mutator phenotype is designated mutY and maps near 64 min on the genetic map of E. coli...
  2. Kervinen M, Pätsi J, Finel M, Hassinen I. A pair of membrane-embedded acidic residues in the NuoK subunit of Escherichia coli NDH-1, a counterpart of the ND4L subunit of the mitochondrial complex I, are required for high ubiquinone reductase activity. Biochemistry. 2004;43:773-81 pubmed
  3. Francis A, Helquist S, Kool E, David S. Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres. J Am Chem Soc. 2003;125:16235-42 pubmed
    The Escherichia coli DNA repair enzymes Fpg and MutY are involved in the prevention of mutations resulting from 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG) in DNA...
  4. Fowler R, White S, Koyama C, Moore S, Dunn R, Schaaper R. Interactions among the Escherichia coli mutT, mutM, and mutY damage prevention pathways. DNA Repair (Amst). 2003;2:159-73 pubmed
    We have investigated in detail the interactions between the Escherichia coli mutT, mutM, and mutY error-prevention systems...
  5. Lu Chang A. Isolation and analyses of MutY homologs (MYH). Methods Enzymol. 2006;408:64-78 pubmed
    The base excision repair carried out by the bacterial MutY DNA glycosylase and eukaryotic MutY homolog (MYH) is responsible for removing adenines misincorporated into DNA opposite 7,8-dihydro-8-oxo-guanines (8-oxoG), thereby preventing G:..
  6. Timms A, Muriel W, Bridges B. A UmuD,C-dependent pathway for spontaneous G:C to C:G transversions in stationary phase Escherichia coli mut Y. Mutat Res. 1999;435:77-80 pubmed
    In Escherichia coli trpA23 bacteria lacking the MutY glycosylase and incubated on plates in the absence of tryptophan, tryptophan-independent mutants continue to arise during incubation over many days...
  7. Klapacz J, Bhagwat A. Transcription promotes guanine to thymine mutations in the non-transcribed strand of an Escherichia coli gene. DNA Repair (Amst). 2005;4:806-13 pubmed
    ..Furthermore, in both mutY and mutM mutY backgrounds the mutations were overwhelmingly G:C to T:A...
  8. Guliaev A, Singer B, Hang B. Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts. DNA Repair (Amst). 2004;3:1311-21 pubmed
    ..However, also as shown by MD, the stacking interaction between the EC base and Phe 30 in the Mug active site is reduced as compared to the epsilonC base, which could account for the lower EC activity observed in this study. ..
  9. Suzuki T, Yamamoto K, Harashima H, Kamiya H. Base excision repair system suppresses mutagenesis caused by 8-hydroxy-dGTP in Escherichia coli. Nucleic Acids Symp Ser (Oxf). 2007;:51-2 pubmed
    ..8-OH-dGTP) was introduced into Escherichia coli strains deficient in endonucleases III (Nth) and VIII (Nei), and MutY, and mutations in the chromosomal rpoB gene were analyzed...
  10. Lin J, Singh R, Cox D. Theoretical study of DNA damage recognition via electron transfer from the [4Fe-4S] complex of MutY. Biophys J. 2008;95:3259-68 pubmed publisher
    The mechanism of site-specific recognition of DNA by proteins has been a long-standing issue. The DNA glycosylase MutY, for instance, must find the rare 8-oxoguanine-adenine mismatches among the large number of basepairs in the DNA...
  11. Burrows C, Fleming A. Finding needles in DNA stacks. Proc Natl Acad Sci U S A. 2009;106:16010-1 pubmed publisher
  12. Khan A, Cash P. E. coli and colon cancer: is mutY a culprit?. Cancer Lett. 2013;341:127-31 pubmed publisher
    ..Surprisingly, the DNA repair gene MUTYH, which is a homologue of the E. coli gene mutY, is responsible for CRC...
  13. van der Kemp P, de Padula M, Burguiere Slezak G, Ulrich H, Boiteux S. PCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 2009;37:2549-59 pubmed publisher
    ..This study suggests that Pol eta and the post-replication repair (PRR) machinery can also prevent mutagenesis at DNA lesions that do not stall replication forks. ..
  14. Kundu S, Brinkmeyer M, Livingston A, David S. Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer. DNA Repair (Amst). 2009;8:1400-10 pubmed publisher
    ..In addition, the ability of MUTYH and the variants to suppress mutations and complement for the absence of MutY in Escherichia coli was assessed using rifampicin resistance assays...
  15. Michaels M, Pham L, Nghiem Y, Cruz C, Miller J. MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III. Nucleic Acids Res. 1990;18:3841-5 pubmed
    The mutY gene of Escherichia coli, which codes for an adenine glycosylase that excises the adenine of a G-A mispair, has been cloned and sequenced...
  16. Notley McRobb L, Pinto R, Seeto S, Ferenci T. Regulation of mutY and nature of mutator mutations in Escherichia coli populations under nutrient limitation. J Bacteriol. 2002;184:739-45 pubmed
    ..One possible explanation for the preponderance of these mutations was that nutrient limitation repressed MutY-dependent DNA repair, resulting in increased proportions of G:C-->T:A transversions...
  17. Gifford C, Blaisdell J, Wallace S. Multiprobe RNase protection assay analysis of mRNA levels for the Escherichia coli oxidative DNA glycosylase genes under conditions of oxidative stress. J Bacteriol. 2000;182:5416-24 pubmed
    Escherichia coli formamidopyrimidine DNA glycosylase (Fpg), MutY DNA glycosylase, endonuclease VIII, and endonuclease III are oxidative base excision repair DNA glycosylases that remove oxidized bases from DNA, or an incorrect base paired ..
  18. Tsai Wu J, Liu H, Lu A. Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairs. Proc Natl Acad Sci U S A. 1992;89:8779-83 pubmed
    In Escherichia coli the mutY (or micA)-dependent DNA mismatch repair pathway can convert A degrees G and A degrees C mismatches to C.G and G.C base pairs, respectively, through a short repair-tract mechanism...
  19. Boon E, Pope M, Williams S, David S, Barton J. DNA-mediated charge transport as a probe of MutY/DNA interaction. Biochemistry. 2002;41:8464-70 pubmed
    b>MutY is an Escherichia coli DNA repair enzyme that binds to 8-oxo-G:A and G:A mismatches and catalyzes the deglycosylation of the mismatched 2'-deoxyadenosine...
  20. Messick T, Chmiel N, Golinelli M, Langer M, Joshua Tor L, David S. Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster. Biochemistry. 2002;41:3931-42 pubmed
    The Escherichia coli DNA repair enzyme MutY plays an important role in the recognition and repair of 7,8-dihydro-8-oxo-2'-deoxyguanosine-2'-deoxyadenosine (OG*A) mismatches in DNA...
  21. Delaney S, Neeley W, Delaney J, Essigmann J. The substrate specificity of MutY for hyperoxidized guanine lesions in vivo. Biochemistry. 2007;46:1448-55 pubmed
    ..One of these enzymes, MutY, excises an A mispaired with 8-oxoG as part of the process to restore the original G:C base pair...
  22. Li L, Lu A. The C-terminal domain of Escherichia coli MutY is involved in DNA binding and glycosylase activities. Nucleic Acids Res. 2003;31:3038-49 pubmed
    Escherichia coli MutY is an adenine and a weak guanine DNA glycosylase involved in reducing mutagenic effects of 7,8-dihydro-8-oxo-guanine (8-oxoG)...
  23. Li X, Lu A. Intact MutY and its catalytic domain differentially contact with A/8-oxoG-containing DNA. Nucleic Acids Res. 2000;28:4593-603 pubmed
    Escherichia coli MutY is an adenine and a weak guanine DNA glycosylase active on DNA substrates containing A/G, A/8-oxoG, A/C or G/8-oxoG mismatches...
  24. Bernards A, Miller J, Bao K, Wong I. Flipping duplex DNA inside out: a double base-flipping reaction mechanism by Escherichia coli MutY adenine glycosylase. J Biol Chem. 2002;277:20960-4 pubmed
    The Escherichia coli MutY adenine glycosylase plays a critical role in repairing mismatches in DNA between adenine and the oxidatively damaged guanine base 8-oxoguanine...
  25. Tsai Wu J, Radicella J, Lu A. Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of micA and mutY. J Bacteriol. 1991;173:1902-10 pubmed
    ..Furthermore, our results suggest that micA is the same gene as the closely mapped mutY, which encodes the A/G mismatch-specific glycosylase.
  26. Boparai K, Dekker E, van Eeden S, Polak M, Bartelsman J, Mathus Vliegen E, et al. Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis. Gastroenterology. 2008;135:2014-8 pubmed publisher
    ..This implies that distinct pathways, that is, APC-gene related in adenomas and nonrelated in HPS/SSAs, appear to be operational in MAP. ..
  27. Lu A, Tsai Wu J, Cillo J. DNA determinants and substrate specificities of Escherichia coli MutY. J Biol Chem. 1995;270:23582-8 pubmed
    Potential DNA contacts involved in the specific interaction between the Escherichia coli MutY protein and a 40-mer oligonucleotide containing an A/G mismatch have been examined by alkylation interference techniques...
  28. House P, Volk D, Thiviyanathan V, Manuel R, Luxon B, Gorenstein D, et al. Potential double-flipping mechanism by E. coli MutY. Prog Nucleic Acid Res Mol Biol. 2001;68:349-64 pubmed
    ..of the recognition and removal of specific mismatched bases in double-stranded DNAs by the DNA repair glycosylase MutY, a series of structural and functional analyses have been conducted...
  29. Sanchez A, Volk D, Gorenstein D, Lloyd R. Initiation of repair of A/G mismatches is modulated by sequence context. DNA Repair (Amst). 2003;2:863-78 pubmed
    ..mismatch, in which the recognition and excision of adenine from the mismatch is mediated by the Escherichia coli MutY enzyme, not only does the local sequence context affect the strength of base stacking interactions, but it also ..
  30. Gifford C, Wallace S. The genes encoding formamidopyrimidine and MutY DNA glycosylases in Escherichia coli are transcribed as part of complex operons. J Bacteriol. 1999;181:4223-36 pubmed
    Escherichia coli formamidopyrimidine (Fpg) DNA glycosylase and MutY DNA glycosylase are base excision repair proteins that work together to protect cells from the mutagenic effects of the commonly oxidized guanine product 7,8-dihydro-8-..
  31. Kosa J, Zdraveski Z, Currier S, Marinus M, Essigmann J. RecN and RecG are required for Escherichia coli survival of Bleomycin-induced damage. Mutat Res. 2004;554:149-57 pubmed
    ..Escherichia coli recA cells were far more sensitive than were uvrA, dam-3, and mutM mutY strains, underscoring the importance of RecA to survival...
  32. Suzuki T, Yamamoto K, Harashima H, Kamiya H. Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP. DNA Repair (Amst). 2008;7:88-94 pubmed
    ..were introduced into Escherichia coli strains deficient in endonucleases III (Nth) and VIII (Nei) and MutY, and mutations in the chromosomal rpoB gene were analyzed...
  33. Notley McRobb L, Seeto S, Ferenci T. Enrichment and elimination of mutY mutators in Escherichia coli populations. Genetics. 2002;162:1055-62 pubmed
    ..The increase in mutation rates was due to sweeps by mutY mutators...
  34. Polosina Y, Mui J, Pitsikas P, Cupples C. The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage. J Bacteriol. 2009;191:4041-3 pubmed publisher
    ..The interaction of MutL with each enzyme is enhanced in vivo by 2-aminopurine treatment and by inactivation of the mutY gene. We hypothesize that MutL recruits the endonucleases to sites of DNA damage.
  35. Williams S, David S. Evidence that MutY is a monofunctional glycosylase capable of forming a covalent Schiff base intermediate with substrate DNA. Nucleic Acids Res. 1998;26:5123-33 pubmed
    The Escherichia coli adenine glycosylase MutY is involved in the repair of 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG):A and G:A mispairs in DNA...
  36. Zharkov D, Grollman A. MutY DNA glycosylase: base release and intermediate complex formation. Biochemistry. 1998;37:12384-94 pubmed
    b>MutY protein, a DNA glycosylase found in Escherichia coli, recognizes dA:dG, dA:8-oxodG, and dA:dC mismatches in duplex DNA, excising the adenine moiety...
  37. Radicella J, Clark E, Chen S, Fox M. Patch length of localized repair events: role of DNA polymerase I in mutY-dependent mismatch repair. J Bacteriol. 1993;175:7732-6 pubmed
    In vivo experiments with heteroduplex lambda genomes show that the MutY mismatch repair system of Escherichia coli defines an average repair tract that is shorter than 27 nucleotides and longer than 9 nucleotides and extends 3' from the ..
  38. Denver D, Swenson S, Lynch M. An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases. Mol Biol Evol. 2003;20:1603-11 pubmed
    ..Six HhH gene families (named AlkA: alkyladenine glycosylase; MpgII: N-methylpurine glycosylase II; MutY/Mig: A/G-specific adenine glycosylase/mismatch glycosylase; Nth: endonuclease III; OggI: 8-oxoguanine glycosylase I;..
  39. Livingston A, Kundu S, Henderson Pozzi M, Anderson D, David S. Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY. Biochemistry. 2005;44:14179-90 pubmed
    ..The Escherichia coli base excision repair glycosylase MutY plays an important role in preventing OG-associated mutations by removing adenines misincorporated opposite OG ..
  40. Lu A, Lee C, Li L, Li X. Physical and functional interactions between Escherichia coli MutY and endonuclease VIII. Biochem J. 2006;393:381-7 pubmed
    ..In Escherichia coli, MutY DNA glycosylase can remove misincorporated adenine opposite G or GO on the template strand during DNA replication...
  41. Hashiguchi K, Zhang Q, Sugiyama H, Ikeda S, Yonei S. Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein. Int J Radiat Biol. 2002;78:585-92 pubmed
    ..Recent studies have shown that 2-ohA is removed from DNA by a human MutY homolog, MYH protein, in vitro...
  42. Lee C, Bai H, Houle R, Wilson G, Lu A. An Escherichia coli MutY mutant without the six-helix barrel domain is a dimer in solution and assembles cooperatively into multisubunit complexes with DNA. J Biol Chem. 2004;279:52653-63 pubmed
    Escherichia coli MutY is an adenine and weak guanine DNA glycosylase involved in reducing the mutagenic effects of 7,8-dihydro-8-oxoguanine (GO)...
  43. Porello S, Cannon M, David S. A substrate recognition role for the [4Fe-4S]2+ cluster of the DNA repair glycosylase MutY. Biochemistry. 1998;37:6465-75 pubmed
    The Escherichia coli DNA repair enzyme MutY plays an important role in the recognition and repair of 7, 8-dihydro-8-oxo-2'-deoxyguanosine: 2'-deoxyadenosine (OG:A) mismatches in DNA [Michaels et al. (1992) Proc. Natl. Acad. Sci. U.S. A...
  44. Au K, Clark S, Miller J, Modrich P. Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. Proc Natl Acad Sci U S A. 1989;86:8877-81 pubmed
    Mutations in the mutY gene of Escherichia coli confer hypermutability reflecting G.C to T.A transversion mutations and result in a deficiency in methyl-independent G-A to G.C mismatch correction...
  45. Gawel D, Pham P, Fijalkowska I, Jonczyk P, Schaaper R. Role of accessory DNA polymerases in DNA replication in Escherichia coli: analysis of the dnaX36 mutator mutant. J Bacteriol. 2008;190:1730-42 pubmed
    ..The present results, including lack of interaction of dnaX36 with mutM, mutY, and recA defects, support our assumption that dnaX36-mediated mutations originate as errors of replication rather ..
  46. Malyarchuk S, Brame K, Youngblood R, Shi R, Harrison L. Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli. Nucleic Acids Res. 2004;32:5721-31 pubmed
    ..The 8-oxodG mutation frequency declined in MutY-deficient bacteria when the opposing 8-oxodG was 6 bp away, and was similar to a single 8-oxodG when the lesions ..
  47. Helling R. Selection of a mutant of Escherichia coli which has high mutation rates. J Bacteriol. 1968;96:975-80 pubmed
    ..This mutation (mut-2) and the Treffers' mutation (mutT1) mapped at approximately the same position to the right of leu. Specificity studies showed that the two mutations differ in rates of mutation produced. ..
  48. Rotman E, Kuzminov A. The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications. J Bacteriol. 2007;189:6976-88 pubmed
    ..Overproduction of the MutM and MutY DNA glycosylases, both acting on DNA containing 8-oxo-G, still yields no lethality in mutT recBC double mutants...
  49. Dantzer F, Bjørås M, Luna L, Klungland A, Seeberg E. Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells. DNA Repair (Amst). 2003;2:707-18 pubmed
    ..coli showed a 50% reduction in the repair of 8-oxoG:C in fpg extracts and an increase to 50% above wild type in mutY. These results show that the mouse OGG1 is the major enzyme for 8-oxoG repair in the MEF cells and does not ..
  50. Livingston A, O Shea V, Kim T, Kool E, David S. Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY. Nat Chem Biol. 2008;4:51-8 pubmed
    Escherichia coli MutY has an important role in preventing mutations associated with the oxidative lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG) in DNA by excising adenines from OG.A mismatches as the first step of base excision repair...
  51. Yoon S, Lee H, Choi J, Kang H, Lee J, Hyun J, et al. MutY is down-regulated by oxidative stress in E. coli. Free Radic Res. 2003;37:873-9 pubmed
    In Escherichia coli, MutM (8-oxoG DNA glycosylase/lyase or Fpg protein), MutY (adenine DNA glycosylase) and MutT (8-oxodGTPase) function cooperatively to prevent mutation due to 7, 8-dihydro-8-oxoguanine (8-oxoG), a highly mutagenic ..
  52. Boal A, Yavin E, Lukianova O, O Shea V, David S, Barton J. DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters. Biochemistry. 2005;44:8397-407 pubmed
    b>MutY and endonuclease III, two DNA glycosylases from Escherichia coli, and AfUDG, a uracil DNA glycosylase from Archeoglobus fulgidus, are all base excision repair enzymes that contain the [4Fe-4S](2+) cofactor...
  53. Wielgoss S, Barrick J, Tenaillon O, Wiser M, Dittmar W, Cruveiller S, et al. Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load. Proc Natl Acad Sci U S A. 2013;110:222-7 pubmed publisher
    ..coli population that first evolved a mutT hypermutator phenotype was later invaded by two independent lineages with mutY mutations that reduced genome-wide mutation rates...
  54. Pope M, Porello S, David S. Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates. J Biol Chem. 2002;277:22605-15 pubmed
    The DNA repair enzyme MutY plays an important role in the prevention of DNA mutations resulting from the presence of the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG)...
  55. Siegel E, Bryson V. Mutator gene of Escherichia coli B. J Bacteriol. 1967;94:38-47 pubmed
    ..No suppression was found. Recombinants were prepared containing mutS1 and the Treffers mutator gene of E. coli K-12. The effect of the mutator genes appears to be additive. ..
  56. Boal A, Yavin E, Barton J. DNA repair glycosylases with a [4Fe-4S] cluster: a redox cofactor for DNA-mediated charge transport?. J Inorg Biochem. 2007;101:1913-21 pubmed
    ..When studied bound to DNA, two of these repair proteins (MutY and Endonuclease III from Escherichia coli) display DNA-dependent reversible electron transfer with characteristics ..
  57. Chang P, Madabushi A, Lu A. Insights into the role of Val45 and Gln182 of Escherichia coli MutY in DNA substrate binding and specificity. BMC Biochem. 2009;10:19 pubmed publisher
    Escherichia coli MutY (EcMutY) reduces mutagenesis by removing adenines paired with guanines or 7,8-dihydro-8-oxo-guanines (8-oxoG). V45 and Q182 of EcMutY are considered to be the key determinants of adenine specificity...
  58. Boal A, Genereux J, Sontz P, Gralnick J, Newman D, Barton J. Redox signaling between DNA repair proteins for efficient lesion detection. Proc Natl Acad Sci U S A. 2009;106:15237-42 pubmed publisher
    ..transport (CT) to mismatched and damaged base pairs, we have proposed that DNA repair glycosylases (EndoIII and MutY) containing a redox-active [4Fe4S] cluster could use DNA CT in signaling one another to search cooperatively for ..
  59. Lu A, Wright P. Characterization of an Escherichia coli mutant MutY with a cysteine to alanine mutation at the iron-sulfur cluster domain. Biochemistry. 2003;42:3742-50 pubmed
    Escherichia coli MutY is an adenine and a weak guanine DNA glycosylase involved in reducing mutagenic effects of 7,8-dihydro-8-oxoguanine (8-oxoG)...
  60. Bai H, Lu A. Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS. J Bacteriol. 2007;189:902-10 pubmed
    Escherichia coli MutY and MutS increase replication fidelity by removing adenines that were misincorporated opposite 7,8-dihydro-8-oxo-deoxyguanines (8-oxoG), G, or C...