Gene Symbol: mreD
Description: cell wall structural complex MreBCD transmembrane component MreD
Alias: ECK3237, JW3218
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Young K. Why spherical Escherichia coli dies: the inside story. J Bacteriol. 2008;190:1497-8 pubmed publisher
  2. Wachi M, Doi M, Tamaki S, Park W, Nakajima Iijima S, Matsuhashi M. Mutant isolation and molecular cloning of mre genes, which determine cell shape, sensitivity to mecillinam, and amount of penicillin-binding proteins in Escherichia coli. J Bacteriol. 1987;169:4935-40 pubmed
    ..Southern blot hybridization indicated that the mre-678 mutant had a large deletion of 5.25 kb in its DNA, covering at least part of the mre-129 gene. ..
  3. Kruse T, Bork Jensen J, Gerdes K. The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex. Mol Microbiol. 2005;55:78-89 pubmed
    ..Using GFP and cell fractionation methods, we showed that the MreC and MreD proteins were associated with the cell membrane...
  4. Tanner R, McInerney M, Nagle D. Formate auxotroph of Methanobacterium thermoautotrophicum Marburg. J Bacteriol. 1989;171:6534-8 pubmed
    ..Moreover, because methanogenesis from H2-CO2 is not impaired in the mutant, free formate is not an intermediate in the reduction of CO2 to CH4. ..
  5. Osborn M, Rothfield L. Cell shape determination in Escherichia coli. Curr Opin Microbiol. 2007;10:606-10 pubmed
    ..Known members of the morphogenetic system include MreB (or Mbl), MreC, MreD and PBP2, but Rod A and murein biosynthetic enzymes involved in peptidoglycan precursor synthesis and assembly are ..
  6. Kruse T, Gerdes K. Bacterial DNA segregation by the actin-like MreB protein. Trends Cell Biol. 2005;15:343-5 pubmed
    ..In particular, a recent study by Gitai et al. demonstrates that MreB specifically binds to and segregates the replication origin of the bacterial chromosome. ..
  7. Wachi M, Doi M, Okada Y, Matsuhashi M. New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells. J Bacteriol. 1989;171:6511-6 pubmed
    New shape-determining genes in the mre cluster at 71 min on the Escherichia coli chromosome map, named mreC and mreD, were identified by complementation experiments using delta mre-678 mutant cells, which have a 5-kilobase-pair deletion ..
  8. Pradel N, Delmas J, Wu L, Santini C, Bonnet R. Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. Antimicrob Agents Chemother. 2009;53:242-8 pubmed publisher
    ..coli. These findings provide new knowledge about beta-lactamase translocation, a putative new target for addressing beta-lactamase-mediated resistance. ..
  9. Bendezú F, de Boer P. Conditional lethality, division defects, membrane involution, and endocytosis in mre and mrd shape mutants of Escherichia coli. J Bacteriol. 2008;190:1792-811 pubmed
    Maintenance of rod shape in Escherichia coli requires the shape proteins MreB, MreC, MreD, MrdA (PBP2), and MrdB (RodA). How loss of the Mre proteins affects E. coli viability has been unclear...

More Information


  1. Vats P, Rothfield L. Duplication and segregation of the actin (MreB) cytoskeleton during the prokaryotic cell cycle. Proc Natl Acad Sci U S A. 2007;104:17795-800 pubmed
    ..The cytoskeletal division and segregation events occur before and independently of cytokinesis and involve specialized MreB structures that appear to be intermediates in this process. ..
  2. Mohammadi T, Karczmarek A, Crouvoisier M, Bouhss A, Mengin Lecreulx D, Den Blaauwen T. The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli. Mol Microbiol. 2007;65:1106-21 pubmed
    ..It is postulated that the involvement of MurG in the peptidoglycan synthesis concurs with two complexes, one implicated in cell elongation and the other in division. A model representing the first complex is proposed. ..
  3. Wachi M, Osaka K, Kohama T, Sasaki K, Ohtsu I, Iwai N, et al. Transcriptional analysis of the Escherichia coli mreBCD genes responsible for morphogenesis and chromosome segregation. Biosci Biotechnol Biochem. 2006;70:2712-9 pubmed
    ..Just downstream of mreB, the mreC and mreD genes are located...
  4. Espeli O, Nurse P, Levine C, Lee C, Marians K. SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli. Mol Microbiol. 2003;50:495-509 pubmed
    ..SetB localizes in the cell as a helix and interacts with MreB, the bacterial actin homologue, which also forms a helix. These observations suggest that there may be a link between chromosome segregation and cellular infrastructure. ..
  5. Kruse T, Møller Jensen J, Løbner Olesen A, Gerdes K. Dysfunctional MreB inhibits chromosome segregation in Escherichia coli. EMBO J. 2003;22:5283-92 pubmed
    ..Our observations indicate that MreB filaments participate in directional chromosome movement and segregation. ..
  6. Wachi M, Doi M, Ueda T, Ueki M, Tsuritani K, Nagai K, et al. Sequence of the downstream flanking region of the shape-determining genes mreBCD of Escherichia coli. Gene. 1991;106:135-6 pubmed
    The nucleotide sequence of the downstream flanking region of the mreD gene of Escherichia coli was determined. Two open reading frames (ORFs) were found, a 591-bp orfE and a 1467-bp orfF...
  7. Figge R, Divakaruni A, Gober J. MreB, the cell shape-determining bacterial actin homologue, co-ordinates cell wall morphogenesis in Caulobacter crescentus. Mol Microbiol. 2004;51:1321-32 pubmed
    ..We hypothesize that MreB filaments function as a cytoskeleton that serves as an organizer or tracking device for the PBP2-peptidoglycan biosynthesis complex...
  8. Vats P, Shih Y, Rothfield L. Assembly of the MreB-associated cytoskeletal ring of Escherichia coli. Mol Microbiol. 2009;72:170-82 pubmed publisher
    ..We show here that the MreB cytoskeletal ring also contains the MreC, MreD, Pbp2 and RodA proteins...