Gene Symbol: mqsA
Description: antitoxin for MqsR toxin; transcriptional repressor
Alias: ECK3012, JW2989, ygiT
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Shah D, Zhang Z, Khodursky A, Kaldalu N, Kurg K, Lewis K. Persisters: a distinct physiological state of E. coli. BMC Microbiol. 2006;6:53 pubmed
    ..We report a method for persister isolation and conclude that these cells represent a distinct state of bacterial physiology. ..
  2. Kim Y, Wood T. Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochem Biophys Res Commun. 2010;391:209-13 pubmed publisher
    ..We showed previously that MqsR and MqsA of Escherichia coli are a toxin-antitoxin pair that influence cell physiology (e.g...
  3. Kim Y, Wang X, Zhang X, Grigoriu S, Page R, Peti W, et al. Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ Microbiol. 2010;12:1105-21 pubmed publisher
    ..Here we show that MqsR and MqsA (YgiT) are a toxin/antitoxin (TA) pair, which, in significant difference to other TA pairs, regulates additional ..
  4. Yamaguchi Y, Park J, Inouye M. MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J Biol Chem. 2009;284:28746-53 pubmed publisher
    ..Here, we found that 1 base downstream of mqsR there is a gene, ygiT, that is co-transcribed with mqsR...
  5. Patrick W, Quandt E, Swartzlander D, Matsumura I. Multicopy suppression underpins metabolic evolvability. Mol Biol Evol. 2007;24:2716-22 pubmed
    ..This genome-wide survey demonstrates that multifunctional genes are common and illustrates the mechanistic diversity by which their products enhance metabolic robustness and evolvability. ..
  6. Brown B, Grigoriu S, Kim Y, Arruda J, Davenport A, Wood T, et al. Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog. 2009;5:e1000706 pubmed publisher
    ..Here, we report multiple individual and complex three-dimensional structures of MqsR and its antitoxin MqsA (B3021), which reveal that MqsR:MqsA form a novel toxin:antitoxin (TA) pair...
  7. Brown B, Page R. Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1060-3 pubmed publisher
    The Escherichia coli proteins MqsR and MqsA comprise a novel toxin-antitoxin (TA) system...
  8. Papadopoulos E, Collet J, Vukojevi V, Billeter M, Holmgren A, Gr slund A, et al. Solution structure and biophysical properties of MqsA, a Zn-containing antitoxin from Escherichia coli. Biochim Biophys Acta. 2012;1824:1401-8 pubmed publisher
    The gene ygiT (mqsA) of Escherichia coli encodes MqsA, the antitoxin of the motility quorum sensing regulator (MqsR)...
  9. Yamaguchi Y, Inouye M. mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems. Prog Mol Biol Transl Sci. 2009;85:467-500 pubmed publisher
    ..We propose that mRNA interferases play roles not only in cell growth regulation and programmed cell death, but also in regulation of specific gene expression (either positively or negatively) in bacteria. ..

More Information


  1. Papadopoulos E, Billeter M, Gräslund A, Vlamis Gardikas A. Assignment of (1)H, (13)C, and (15)N resonances of YgiT, a putative DNA interacting protein from E. coli, containing one HTH and two CxxC motifs. Biomol NMR Assign. 2007;1:217-9 pubmed publisher
    The 131 residues protein encoded by the open reading frame ygiT of E...
  2. Wang X, Kim Y, Hong S, Ma Q, Brown B, Pu M, et al. Antitoxin MqsA helps mediate the bacterial general stress response. Nat Chem Biol. 2011;7:359-66 pubmed publisher
    ..Specifically, the antitoxin MqsA represses rpoS, which encodes the master regulator of stress...
  3. Inouye M. The discovery of mRNA interferases: implication in bacterial physiology and application to biotechnology. J Cell Physiol. 2006;209:670-6 pubmed
    ..The discovery of a novel way to interfere with mRNA function by mRNA interferases opens a wide variety of avenues in basic as well as applied and clinical sciences. ..
  4. Uppal S, Jawali N. The cyclic AMP receptor protein (CRP) regulates mqsRA, coding for the bacterial toxin-antitoxin gene pair, in Escherichia coli. Res Microbiol. 2016;167:58-62 pubmed publisher
    ..MqsR-MqsA, the toxin-antitoxin (TA) pair, is the most frequently induced TA system associated with antibiotic persistence in ..
  5. Christensen Dalsgaard M, Jørgensen M, Gerdes K. Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol Microbiol. 2010;75:333-48 pubmed publisher
    ..Induction of the three loci depended on Lon protease that may sense the environmental stresses and activate TA loci by cleavage of the antitoxins. Transcription of the three TA operons was autoregulated by the antitoxins. ..