Genomes and Genes
Gene Symbol: modC
Description: molybdate ABC transporter ATPase; chlorate resistance protein
Alias: ECK0754, JW0748, chlD, narD
Species: Escherichia coli str. K-12 substr. MG1655
- McNicholas P, Rech S, Gunsalus R. Characterization of the ModE DNA-binding sites in the control regions of modABCD and moaABCDE of Escherichia coli. Mol Microbiol. 1997;23:515-24 pubmed..These findings demonstrate that ModE acts both as a repressor and activator of the mod and moa operons, respectively, depending on the properties of the binding site. ..
- McNicholas P, Chiang R, Gunsalus R. The Escherichia coli modE gene: effect of modE mutations on molybdate dependent modA expression. FEMS Microbiol Lett. 1996;145:117-23 pubmed..Finally, a mutational analysis of a proposed molybdate binding motif indicates that this motif does not function in regulating the repressor activity of ModE. ..
- del Campillo Campbell A, Campbell A. Molybdenum cofactor requirement for biotin sulfoxide reduction in Escherichia coli. J Bacteriol. 1982;149:469-78 pubmed..Mutational inactivation of the chlD gene reduces the specific activity of biotin sulfoxide reductase about twofold...
- Adhya S, Cleary P, Campbell A. A deletion analysis of prophage lambda and adjacent genetic regions. Proc Natl Acad Sci U S A. 1968;61:956-62 pubmed
- Grunden A, Shanmugam K. Molybdate transport and regulation in bacteria. Arch Microbiol. 1997;168:345-54 pubmed..These three proteins are coded by modA, modB, and modC genes, respectively...
- Joshi M, Johnson J, Rajagopalan K. Molybdenum cofactor biosynthesis in Escherichia coli mod and mog mutants. J Bacteriol. 1996;178:4310-2 pubmed..The results are in accord with complete phenotypic repair of mod, and incomplete repair of mog, by culture in high concentrations of molybdate. A possible role for Mog as a molybdochelatase is discussed. ..
- Miyake H, Yabu H, Satoh T, Yamamoto I. Characterization and transcriptional regulation of the modABCD genes for molybdenum transport in Escherichia coli. Nucleic Acids Symp Ser. 1995;:91-2 pubmed..The nucleotide sequence of 3048-base pair showed four open reading frames including the previously reported modC gene. The genes were named modA, modB, modC, and modD...
- Rosentel J, Healy F, Maupin Furlow J, Lee J, Shanmugam K. Molybdate and regulation of mod (molybdate transport), fdhF, and hyc (formate hydrogenlyase) operons in Escherichia coli. J Bacteriol. 1995;177:4857-64 pubmed..This level was increased by over 175 times by a mutation in the modA, modB, or modC gene. The addition of molybdate to the growth medium of a mod mutant lowered phi (modA'-'lacZ+) expression...
- Bachmann B. Linkage map of Escherichia coli K-12, edition 7. Microbiol Rev. 1983;47:180-230 pubmed
- Glaser J, DeMoss J. Comparison of nitrate reductase mutants of Escherichia coli selected by alternative procedures. Mol Gen Genet. 1972;116:1-10 pubmed
- Maupin Furlow J, Rosentel J, Lee J, Deppenmeier U, Gunsalus R, Shanmugam K. Genetic analysis of the modABCD (molybdate transport) operon of Escherichia coli. J Bacteriol. 1995;177:4851-6 pubmed..second gene (modB) encodes a 229-amino-acid protein with a potential membrane location, while the 352-amino-acid ModC protein (modC product) contains a nucleotide-binding motif...
- Dudev T, Lim C. Oxyanion selectivity in sulfate and molybdate transport proteins: an ab initio/CDM study. J Am Chem Soc. 2004;126:10296-305 pubmed
- Imperial J, Hadi M, Amy N. Molybdate binding by ModA, the periplasmic component of the Escherichia coli mod molybdate transport system. Biochim Biophys Acta. 1998;1370:337-46 pubmed..The affinity of ModA for molybdate was also determined in vivo and found to be similar to that determined in vitro...
- B bien M, Kirsch J, M jean V, Verm glio A. Involvement of a putative molybdenum enzyme in the reduction of selenate by Escherichia coli. Microbiology. 2002;148:3865-72 pubmed publisher..In addition, all the various mutants were still able to reduce selenite into elemental selenium. This implies that the transport and reduction of this compound are clearly distinct from those of selenate...