Gene Symbol: moaC
Description: molybdopterin biosynthesis, protein C
Alias: ECK0772, JW0766
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. McNicholas P, Rech S, Gunsalus R. Characterization of the ModE DNA-binding sites in the control regions of modABCD and moaABCDE of Escherichia coli. Mol Microbiol. 1997;23:515-24 pubmed
    ..These findings demonstrate that ModE acts both as a repressor and activator of the mod and moa operons, respectively, depending on the properties of the binding site. ..
  2. Wuebbens M, Liu M, Rajagopalan K, Schindelin H. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Structure. 2000;8:709-18 pubmed
    ..The MoaC protein, together with the MoaA protein, is involved in the first step of Moco biosynthesis...
  3. Levy E, Boeri Erba E, Robinson C, Teichmann S. Assembly reflects evolution of protein complexes. Nature. 2008;453:1262-5 pubmed publisher
    ..Our model of self-assembly allows reliable prediction of evolution and assembly of a complex solely from its crystal structure. ..
  4. Shanmugam K, Stewart V, Gunsalus R, Boxer D, Cole J, Chippaux M, et al. Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Salmonella typhimurium. Mol Microbiol. 1992;6:3452-4 pubmed
  5. Rivers S, McNairn E, Blasco F, Giordano G, Boxer D. Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis. Mol Microbiol. 1993;8:1071-81 pubmed
    ..The moa locus is orientated clockwise at 17.7 minutes in the chromosome. ..
  6. Rieder C, Eisenreich W, O Brien J, Richter G, Götze E, Boyle P, et al. Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. Eur J Biochem. 1998;255:24-36 pubmed
    ..Carbon atom C1' of compound Z is derived from carbon atom C8 of a guanine derivative. The remodeling of the carbon skeleton of the pentose and purine moieties proceed via intramolecular rearrangement reactions. ..
  7. Hover B, Tonthat N, Schumacher M, Yokoyama K. Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. Proc Natl Acad Sci U S A. 2015;112:6347-52 pubmed publisher
    ..of guanosine 5'-triphosphate (GTP) into cyclic pyranopterin (cPMP) through the action of two enzymes, MoaA and MoaC (molybdenum cofactor biosynthesis protein A and C, respectively)...
  8. Han K, Park J, Seo H, Ahn K, Lee J. Multiple stressor-induced proteome responses of Escherichia coli BL21(DE3). J Proteome Res. 2008;7:1891-903 pubmed publisher
    ..The quantitative and systematic proteome analyses that we have performed provide more detailed information on E. coli BL21(DE3), a widely used host strain for recombinant protein overexpression. ..
  9. Hover B, Lilla E, Yokoyama K. Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue. Biochemistry. 2015;54:7229-36 pubmed publisher
    ..5'-triphosphate (GTP) into cyclic pyranopterin monophosphate (cPMP) through the action of two enzymes, MoaA and MoaC. Recent studies revealed that MoaC catalyzes the majority of the transformation and produces cPMP from a unique ..