Gene Symbol: mntH
Description: manganese/divalent cation transporter
Alias: ECK2387, JW2388, mntA, yfeP
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Courville P, Chaloupka R, Veyrier F, Cellier M. Determination of transmembrane topology of the Escherichia coli natural resistance-associated macrophage protein (Nramp) ortholog. J Biol Chem. 2004;279:3318-26 pubmed
    ..which was likely derived from a bacterial ortholog and characterized as a proton-dependent manganese transporter MntH (Makui, H., Roig, E., Cole, S. T., Helmann, J. D., Gros, P., and Cellier, M. F. (2000) Mol. Microbiol...
  2. Kehres D, Janakiraman A, Slauch J, Maguire M. Regulation of Salmonella enterica serovar Typhimurium mntH transcription by H(2)O(2), Fe(2+), and Mn(2+). J Bacteriol. 2002;184:3151-8 pubmed
    b>MntH, a bacterial homolog of mammalian natural resistance associated macrophage protein 1 (Nramp1), is a primary transporter for Mn(2+) influx in Salmonella enterica serovar Typhimurium and Escherichia coli. S...
  3. Kehres D, Maguire M. Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria. FEMS Microbiol Rev. 2003;27:263-90 pubmed
    ..This suggests that Mn2+ may play an important role in central carbon metabolism. Further studies will be required, however, to determine whether these or other actions of Mn2+ within the cell are the relevant factors in pathogenesis. ..
  4. Courville P, Urbankova E, Rensing C, Chaloupka R, Quick M, Cellier M. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. J Biol Chem. 2008;283:9651-8 pubmed publisher
    ..To identify residues mediating cation symport, Escherichia coli proton-dependent manganese transporter (MntH) was mutated at five SLC11-specific transmembrane (TM) sites; each mutant activity was compared with wild-type MntH,..
  5. Anjem A, Varghese S, Imlay J. Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli. Mol Microbiol. 2009;72:844-58 pubmed publisher
    ..Mutants that lack MntH, the importer, grow at wild-type rates, indicating that manganese plays no critical role...
  6. Grass G. Iron transport in Escherichia coli: all has not been said and done. Biometals. 2006;19:159-72 pubmed
    ..Moreover, it appears that iron homeostasis consists not only of uptake but also of efflux of this potentially toxic redox-active metal. New findings in E. coli will be discussed and compared to the situation in other bacteria. ..
  7. McEwan A. New insights into the protective effect of manganese against oxidative stress. Mol Microbiol. 2009;72:812-4 pubmed publisher
    ..This enables the cell to avoid oxidative stress associated with iron release in the presence of hydrogen peroxide. ..
  8. Haemig H, Brooker R. Importance of conserved acidic residues in mntH, the Nramp homolog of Escherichia coli. J Membr Biol. 2004;201:97-107 pubmed
    ..e., Asp-34, Glu-102, Asp-109, Glu-112, Glu-154, and Asp-238) in the E. coli Nramp homolog mntH. Of these six, five of them, Asp-34, Glu-102, Asp-109, Glu-112, and Asp-238 appear to be important for function ..
  9. Chaloupka R, Courville P, Veyrier F, Knudsen B, Tompkins T, Cellier M. Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo. Biochemistry. 2005;44:726-33 pubmed
    ..invariant outgroup residues in the Escherichia coli Nramp ortholog (the proton-dependent manganese transporter, MntH of group A, EcoliA)...

More Information


  1. Richer E, Courville P, Bergevin I, Cellier M. Horizontal gene transfer of "prototype" Nramp in bacteria. J Mol Evol. 2003;57:363-76 pubmed publisher
    ..Bacterial homologs encode proton-dependent transporters of manganese (MntH), and other divalent metal ions...
  2. Nunukov√° V, Urbankova E, Jelokhani Niaraki M, Chaloupka R. Ion channel activity of transmembrane segment 6 of Escherichia coli proton-dependent manganese transporter. Biopolymers. 2010;93:718-26 pubmed publisher
    Synthetic peptides corresponding to the sixth transmembrane segment (TMS6) of secondary-active transporter MntH (Proton-dependent Manganese Transporter) from Escherichia coli and its two mutations in the functionally important conserved ..
  3. Patzer S, Hantke K. Dual repression by Fe(2+)-Fur and Mn(2+)-MntR of the mntH gene, encoding an NRAMP-like Mn(2+) transporter in Escherichia coli. J Bacteriol. 2001;183:4806-13 pubmed
    The uptake of Mn(2+), a cofactor for several enzymes in Escherichia coli, is mediated by MntH, a proton-dependent metal transporter, which also recognizes Fe(2+) with lower affinity...
  4. Haemig H, Moen P, Brooker R. Evidence that highly conserved residues of transmembrane segment 6 of Escherichia coli MntH are important for transport activity. Biochemistry. 2010;49:4662-71 pubmed publisher
    ..negatively charged residues, a model was proposed for the metal binding site of the Escherichia coli homologue, MntH. In this study, we have focused on the highly conserved residues, including two histidines, of transmembrane ..
  5. Makui H, Roig E, Cole S, Helmann J, Gros P, Cellier M. Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol Microbiol. 2000;35:1065-78 pubmed
    The Escherichia coli mntH (formerly yfeP) gene encodes a putative membrane protein (MntH) highly similar to members of the eukaryotic Nramp family of divalent metal ion transporters. To determine the function of E...