Research Topics

Genomes and Genes

Gene Symbol: mlaE

Description: ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein

Alias: ECK3183, JW3161, vpsB, yrbE

Species: Escherichia coli str. K-12 substr. MG1655

Hong M, Gleason Y, Wyckoff E, Payne S. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Infect Immun. 1998;66:4700-10 pubmed

..flexneri. The mutant with the insertion at 28 min was interrupted in the same open reading frame as S. flexneri ispA. This ispA mutant could not form plaques and was defective in bacterial septation inside tissue culture cells...
Malinverni J, Silhavy T. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proc Natl Acad Sci U S A. 2009;106:8009-14 pubmed publisher

..We propose that the Mla pathway constitutes a bacterial intermembrane PL trafficking system...
Thong S, Ercan B, Torta F, Fong Z, Wong H, Wenk M, et al. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. elife. 2016;5: pubmed publisher

..We establish that the transporter comprises canonical components, MlaF and MlaE, and auxiliary proteins, MlaD and MlaB, of previously unknown functions...