minD

Summary

Gene Symbol: minD
Description: inhibitor of FtsZ ring polymerization; chromosome-membrane tethering protein; membrane ATPase of the MinCDEE system
Alias: ECK1163, JW1164, minB
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Hu Z, Gogol E, Lutkenhaus J. Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE. Proc Natl Acad Sci U S A. 2002;99:6761-6 pubmed publisher
    ..of the division site in Escherichia coli is regulated by the min system and requires the rapid oscillation of MinD between the two halves of the cell under the control of MinE...
  2. Wu W, Park K, Holyoak T, Lutkenhaus J. Determination of the structure of the MinD-ATP complex reveals the orientation of MinD on the membrane and the relative location of the binding sites for MinE and MinC. Mol Microbiol. 2011;79:1515-28 pubmed publisher
    ..b>MinD binds to vesicles in the presence of ATP and can recruit MinC or MinE...
  3. Suefuji K, Valluzzi R, RayChaudhuri D. Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE. Proc Natl Acad Sci U S A. 2002;99:16776-81 pubmed publisher
    Accurate positioning of the division septum at the equator of Escherichia coli cells requires a rapid oscillation of MinD ATPase between the polar halves of the cell membrane, together with the division inhibitor MinC, under MinE control...
  4. Shih Y, Fu X, King G, Le T, Rothfield L. Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. EMBO J. 2002;21:3347-57 pubmed publisher
    ..MinE assembles into a membrane-associated ring structure near midcell and directs the localization of MinD and MinC into a membrane- associated polar zone that undergoes a characteristic pole-to-pole oscillation cycle...
  5. Fu X, Shih Y, Zhang Y, Rothfield L. The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle. Proc Natl Acad Sci U S A. 2001;98:980-5 pubmed
    ..Taken together with studies of the dynamic behavior of the MinD protein, the results suggest that the topological specificity of division site placement may not involve a ..
  6. Kruse K, Howard M, Margolin W. An experimentalist's guide to computational modelling of the Min system. Mol Microbiol. 2007;63:1279-84 pubmed
    ..We also review the effects of fluctuations caused by low cellular concentration of Min proteins, and describe how stochastic effects may potentially influence Min protein dynamics. ..
  7. Thanedar S, Margolin W. FtsZ exhibits rapid movement and oscillation waves in helix-like patterns in Escherichia coli. Curr Biol. 2004;14:1167-73 pubmed
    ..The MreB helix was not required for the rapid movement of FtsZ or the oscillation of MinD. The results suggest that FtsZ not only forms the Z ring but also is part of a highly dynamic, potentially helical ..
  8. Szeto T, Rowland S, Rothfield L, King G. Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts. Proc Natl Acad Sci U S A. 2002;99:15693-8 pubmed publisher
    b>MinD is a widely conserved ATPase that has been demonstrated to play a pivotal role in selection of the division site in eubacteria and chloroplasts...
  9. Raskin D, de Boer P. The MinE ring: an FtsZ-independent cell structure required for selection of the correct division site in E. coli. Cell. 1997;91:685-94 pubmed
    ..Formation of the MinE ring required MinD but was independent of MinC and continued in nondividing cells in which FtsZ function was inhibited...
  10. Meinhardt H, de Boer P. Pattern formation in Escherichia coli: a model for the pole-to-pole oscillations of Min proteins and the localization of the division site. Proc Natl Acad Sci U S A. 2001;98:14202-7 pubmed publisher
    ..we show that Min protein dynamics can be described accurately by using the following assumptions: (i) the MinD ATPase self-assembles on the membrane and recruits both MinC, an inhibitor of Z ring formation, and MinE, a protein ..

Detail Information

Publications76

  1. Hu Z, Gogol E, Lutkenhaus J. Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE. Proc Natl Acad Sci U S A. 2002;99:6761-6 pubmed publisher
    ..of the division site in Escherichia coli is regulated by the min system and requires the rapid oscillation of MinD between the two halves of the cell under the control of MinE...
  2. Wu W, Park K, Holyoak T, Lutkenhaus J. Determination of the structure of the MinD-ATP complex reveals the orientation of MinD on the membrane and the relative location of the binding sites for MinE and MinC. Mol Microbiol. 2011;79:1515-28 pubmed publisher
    ..b>MinD binds to vesicles in the presence of ATP and can recruit MinC or MinE...
  3. Suefuji K, Valluzzi R, RayChaudhuri D. Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE. Proc Natl Acad Sci U S A. 2002;99:16776-81 pubmed publisher
    Accurate positioning of the division septum at the equator of Escherichia coli cells requires a rapid oscillation of MinD ATPase between the polar halves of the cell membrane, together with the division inhibitor MinC, under MinE control...
  4. Shih Y, Fu X, King G, Le T, Rothfield L. Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. EMBO J. 2002;21:3347-57 pubmed publisher
    ..MinE assembles into a membrane-associated ring structure near midcell and directs the localization of MinD and MinC into a membrane- associated polar zone that undergoes a characteristic pole-to-pole oscillation cycle...
  5. Fu X, Shih Y, Zhang Y, Rothfield L. The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle. Proc Natl Acad Sci U S A. 2001;98:980-5 pubmed
    ..Taken together with studies of the dynamic behavior of the MinD protein, the results suggest that the topological specificity of division site placement may not involve a ..
  6. Kruse K, Howard M, Margolin W. An experimentalist's guide to computational modelling of the Min system. Mol Microbiol. 2007;63:1279-84 pubmed
    ..We also review the effects of fluctuations caused by low cellular concentration of Min proteins, and describe how stochastic effects may potentially influence Min protein dynamics. ..
  7. Thanedar S, Margolin W. FtsZ exhibits rapid movement and oscillation waves in helix-like patterns in Escherichia coli. Curr Biol. 2004;14:1167-73 pubmed
    ..The MreB helix was not required for the rapid movement of FtsZ or the oscillation of MinD. The results suggest that FtsZ not only forms the Z ring but also is part of a highly dynamic, potentially helical ..
  8. Szeto T, Rowland S, Rothfield L, King G. Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts. Proc Natl Acad Sci U S A. 2002;99:15693-8 pubmed publisher
    b>MinD is a widely conserved ATPase that has been demonstrated to play a pivotal role in selection of the division site in eubacteria and chloroplasts...
  9. Raskin D, de Boer P. The MinE ring: an FtsZ-independent cell structure required for selection of the correct division site in E. coli. Cell. 1997;91:685-94 pubmed
    ..Formation of the MinE ring required MinD but was independent of MinC and continued in nondividing cells in which FtsZ function was inhibited...
  10. Meinhardt H, de Boer P. Pattern formation in Escherichia coli: a model for the pole-to-pole oscillations of Min proteins and the localization of the division site. Proc Natl Acad Sci U S A. 2001;98:14202-7 pubmed publisher
    ..we show that Min protein dynamics can be described accurately by using the following assumptions: (i) the MinD ATPase self-assembles on the membrane and recruits both MinC, an inhibitor of Z ring formation, and MinE, a protein ..
  11. Howard M, Rutenberg A, de Vet S. Dynamic compartmentalization of bacteria: accurate division in E. coli. Phys Rev Lett. 2001;87:278102 pubmed publisher
    ..coli is controlled by the min system of proteins: MinC, MinD, and MinE. These proteins coherently oscillate from end to end of the bacterium...
  12. Kruse K. A dynamic model for determining the middle of Escherichia coli. Biophys J. 2002;82:618-27 pubmed publisher
    ..In Escherichia coli, this process depends crucially on the proteins MinC, MinD, and MinE...
  13. Juarez J, Margolin W. Changes in the Min oscillation pattern before and after cell birth. J Bacteriol. 2010;192:4134-42 pubmed publisher
    The Min system regulates the positioning of the cell division site in many bacteria. In Escherichia coli, MinD migrates rapidly from one cell pole to the other...
  14. Kerr R, Levine H, Sejnowski T, Rappel W. Division accuracy in a stochastic model of Min oscillations in Escherichia coli. Proc Natl Acad Sci U S A. 2006;103:347-52 pubmed
    Accurate cell division in Escherichia coli requires the Min proteins MinC, MinD, and MinE as well as the presence of nucleoids...
  15. Hu Z, Lutkenhaus J. Topological regulation of cell division in E. coli. spatiotemporal oscillation of MinD requires stimulation of its ATPase by MinE and phospholipid. Mol Cell. 2001;7:1337-43 pubmed
    ..This positioning is achieved through a rapid oscillation of MinC from pole to pole, a process requiring MinD and MinE. However, the mechanistic basis for this oscillation is not known...
  16. Lutkenhaus J. Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring. Annu Rev Biochem. 2007;76:539-62 pubmed
    ..Additional gradients of negative regulators of FtsZ assembly are used by E. coli and other bacteria to achieve spatial control of Z-ring assembly. ..
  17. Hu Z, Lutkenhaus J. A conserved sequence at the C-terminus of MinD is required for binding to the membrane and targeting MinC to the septum. Mol Microbiol. 2003;47:345-55 pubmed
    b>MinD is a key component of an oscillatory system that spatially regulates cell division in Escherichia coli...
  18. Huang K, Meir Y, Wingreen N. Dynamic structures in Escherichia coli: spontaneous formation of MinE rings and MinD polar zones. Proc Natl Acad Sci U S A. 2003;100:12724-8 pubmed
    ..oscillatory structures produced by the Min proteins, including a ring of MinE protein, compact polar zones of MinD, and zebra-striped oscillations in filamentous cells, remain unexplained...
  19. Zhou H, Lutkenhaus J. Membrane binding by MinD involves insertion of hydrophobic residues within the C-terminal amphipathic helix into the bilayer. J Bacteriol. 2003;185:4326-35 pubmed
    b>MinD binds to phospholipid vesicles in the presence of ATP and is released by MinE, which stimulates the MinD ATPase. Membrane binding requires a short conserved C-terminal region, which has the potential to form an amphipathic helix...
  20. Howard M, Rutenberg A. Pattern formation inside bacteria: fluctuations due to the low copy number of proteins. Phys Rev Lett. 2003;90:128102 pubmed publisher
    ..We find that, for some parameter regions, the protein concentrations are low enough that fluctuations are essential for the generation of patterns. We also examine the role of fluctuations in constraining protein concentration levels...
  21. Shih Y, Le T, Rothfield L. Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles. Proc Natl Acad Sci U S A. 2003;100:7865-70 pubmed publisher
    ..coli and that structures of this type can undergo dynamic changes that play important roles in division site placement and possibly other aspects of the life of the cell...
  22. de Boer P, Crossley R, Hand A, Rothfield L. The MinD protein is a membrane ATPase required for the correct placement of the Escherichia coli division site. EMBO J. 1991;10:4371-80 pubmed
    ..site-specific inactivation of potential division sites at the cell poles in a process that is mediated by the MinC, MinD and MinE proteins. During the normal division cycle MinD plays two roles...
  23. de Boer P, Crossley R, Rothfield L. A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli. Cell. 1989;56:641-9 pubmed
    The E. coli minicell locus (minB) was shown to code for three gene products (MinC, MinD, and MinE) whose coordinate action is required for proper placement of the division spetum...
  24. Marston A, Thomaides H, Edwards D, Sharpe M, Errington J. Polar localization of the MinD protein of Bacillus subtilis and its role in selection of the mid-cell division site. Genes Dev. 1998;12:3419-30 pubmed
    ..DivIVA then recruits MinD to the division sites preventing another division from taking place near the newly formed cell poles...
  25. Raskin D, de Boer P. Rapid pole-to-pole oscillation of a protein required for directing division to the middle of Escherichia coli. Proc Natl Acad Sci U S A. 1999;96:4971-6 pubmed
    ..of a general division inhibitor (MinC), a site-specific suppressor of division inhibition (MinE), and an ATPase (MinD) that is required for proper functioning of both MinC and MinE...
  26. Anderson D, Gueiros Filho F, Erickson H. Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. J Bacteriol. 2004;186:5775-81 pubmed
    ..In B. subtilis, only 30 to 35% of the FtsZ protein was in the Z ring, from which we conclude that a Z ring only 2 or 3 protofilaments thick can function for cell division. ..
  27. Osawa M, Anderson D, Erickson H. Reconstitution of contractile FtsZ rings in liposomes. Science. 2008;320:792-4 pubmed publisher
    ..Brighter Z rings produced visible constrictions in the liposome, suggesting that FtsZ itself can assemble the Z ring and generate a force. No other proteins were needed for assembly and force generation. ..
  28. Rowland S, Fu X, Sayed M, Zhang Y, Cook W, Rothfield L. Membrane redistribution of the Escherichia coli MinD protein induced by MinE. J Bacteriol. 2000;182:613-9 pubmed
    ..Selection of the correct division site at midcell is controlled by three proteins: MinC, MinD, and MinE. It has previously been shown (D. Raskin and P...
  29. Tostevin F, Howard M. A stochastic model of Min oscillations in Escherichia coli and Min protein segregation during cell division. Phys Biol. 2005;3:1-12 pubmed
    ..We present a one-dimensional stochastic model of these oscillations which incorporates membrane polymerization of MinD into linear chains...
  30. Shih Y, Kawagishi I, Rothfield L. The MreB and Min cytoskeletal-like systems play independent roles in prokaryotic polar differentiation. Mol Microbiol. 2005;58:917-28 pubmed
    ..Thus, the two bacterial cytoskeletal-like systems act independently on different aspects of cell polarization. ..
  31. Hale C, Meinhardt H, de Boer P. Dynamic localization cycle of the cell division regulator MinE in Escherichia coli. EMBO J. 2001;20:1563-72 pubmed
    ..b>MinD and MinE regulate MinC activity by modulating its cellular location in a unique fashion...
  32. Szeto T, Rowland S, Habrukowich C, King G. The MinD membrane targeting sequence is a transplantable lipid-binding helix. J Biol Chem. 2003;278:40050-6 pubmed publisher
    b>MinD is a ubiquitous ATPase that plays a crucial role in selection of the division site in eubacteria, chloroplasts, and probably also Archaea...
  33. Ramirez Arcos S, Szeto J, Dillon J, Margolin W. Conservation of dynamic localization among MinD and MinE orthologues: oscillation of Neisseria gonorrhoeae proteins in Escherichia coli. Mol Microbiol. 2002;46:493-504 pubmed
    ..coli. Green fluorescent protein (GFP) fusions to gonococcal MinD and MinE localized dynamically in different E. coli backgrounds. GFP-MinDNg moved from pole to pole in rod-shaped E...
  34. Corbin B, Yu X, Margolin W. Exploring intracellular space: function of the Min system in round-shaped Escherichia coli. EMBO J. 2002;21:1998-2008 pubmed publisher
    ..In round cells with a long axis, such as those undergoing cell division, green fluorescent protein (GFP) fusions to MinD almost always oscillated parallel to the long axis...
  35. Lackner L, Raskin D, de Boer P. ATP-dependent interactions between Escherichia coli Min proteins and the phospholipid membrane in vitro. J Bacteriol. 2003;185:735-49 pubmed
    ..MinC dynamics involves a membrane association-dissociation cycle that is driven by the activities of the MinD ATPase and the MinE topological specificity factor, which themselves undergo coupled oscillatory localization ..
  36. Mileykovskaya E, Fishov I, Fu X, Corbin B, Margolin W, Dowhan W. Effects of phospholipid composition on MinD-membrane interactions in vitro and in vivo. J Biol Chem. 2003;278:22193-8 pubmed publisher
    The peripheral membrane ATPase MinD is a component of the Min system responsible for correct placement of the division site in Escherichia coli cells...
  37. Akerlund T, Bernander R, Nordstrom K. Cell division in Escherichia coli minB mutants. Mol Microbiol. 1992;6:2073-83 pubmed
    In Escherichia coli minB mutants, cell division can take place at the cell poles as well as non-polarly in the cell...
  38. Drew D, Osborn M, Rothfield L. A polymerization-depolymerization model that accurately generates the self-sustained oscillatory system involved in bacterial division site placement. Proc Natl Acad Sci U S A. 2005;102:6114-8 pubmed
    ..bacteria involves a unique spatial oscillatory system in which membrane-associated structures composed of the MinC, MinD and MinE proteins oscillate rapidly between the two cell poles...
  39. Touhami A, Jericho M, Rutenberg A. Temperature dependence of MinD oscillation in Escherichia coli: running hot and fast. J Bacteriol. 2006;188:7661-7 pubmed
    We observed that the oscillation period of MinD within rod-like and filamentous cells of Escherichia coli varied by a factor of 4 in the temperature range from 20 degrees C to 40 degrees C...
  40. Hayashi I, Oyama T, Morikawa K. Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus. EMBO J. 2001;20:1819-28 pubmed publisher
    ..In Escherichia coli, selection of the correct mid-cell site is mediated by the MinC, MinD and MinE proteins...
  41. Hu Z, Lutkenhaus J. Topological regulation of cell division in Escherichia coli involves rapid pole to pole oscillation of the division inhibitor MinC under the control of MinD and MinE. Mol Microbiol. 1999;34:82-90 pubmed
    ..This activity of min is achieved through the action of an inhibitor of division, MinC, that is activated by MinD and topologically regulated by MinE...
  42. Raskin D, de Boer P. MinDE-dependent pole-to-pole oscillation of division inhibitor MinC in Escherichia coli. J Bacteriol. 1999;181:6419-24 pubmed
    ..MinC activity requires that of MinD, and the MinE peptide provides topological specificity by suppressing MinC-MinD-mediated division inhibition ..
  43. Loose M, Fischer Friedrich E, Ries J, Kruse K, Schwille P. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science. 2008;320:789-92 pubmed publisher
    ..We present a reaction-diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations.
  44. Akerlund T, Gullbrand B, Nordstr m K. Effects of the Min system on nucleoid segregation in Escherichia coli. Microbiology. 2002;148:3213-22 pubmed publisher
    ..the mid-cell by a mechanism that involves the dynamic localization of all of its three constituent proteins, MinC, MinD and MinE. Both the Min system and the nucleoid regulate cell division negatively and strains of E...
  45. Zhou H, Schulze R, Cox S, Saez C, Hu Z, Lutkenhaus J. Analysis of MinD mutations reveals residues required for MinE stimulation of the MinD ATPase and residues required for MinC interaction. J Bacteriol. 2005;187:629-38 pubmed
    The MinD ATPase is critical to the oscillation of the Min proteins, which limits formation of the Z ring to midcell...
  46. Hu Z, Saez C, Lutkenhaus J. Recruitment of MinC, an inhibitor of Z-ring formation, to the membrane in Escherichia coli: role of MinD and MinE. J Bacteriol. 2003;185:196-203 pubmed
    ..We observed that MinD dimerized in the presence of ATP and interacted with MinC...
  47. Galperin M, Grishin N. The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase. Proteins. 2000;41:238-47 pubmed
    ..Further database searches showed that this enzyme family is also related to the MinD family of ATPases involved in regulation of cell division in bacteria and archaea...
  48. Dassain M, Bouche J. The min locus, which confers topological specificity to cell division, is not involved in its coupling with nucleoid separation. J Bacteriol. 1994;176:6143-5 pubmed
    ..We suggest that the retarded nucleoid segregation observed in min mutants is the result of this coupling in cells with a perturbed pattern of nonpolar divisions. ..
  49. Meacci G, Ries J, Fischer Friedrich E, Kahya N, Schwille P, Kruse K. Mobility of Min-proteins in Escherichia coli measured by fluorescence correlation spectroscopy. Phys Biol. 2006;3:255-63 pubmed
    In the bacterium Escherichia coli, selection of the division site involves pole-to-pole oscillations of the proteins MinD and MinE...
  50. Varma A, Huang K, Young K. The Min system as a general cell geometry detection mechanism: branch lengths in Y-shaped Escherichia coli cells affect Min oscillation patterns and division dynamics. J Bacteriol. 2008;190:2106-17 pubmed publisher
    ..The results provide further evidence that Min protein oscillations act as a general cell geometry detection mechanism that can locate poles even in branched cells. ..
  51. Borowski P, Cytrynbaum E. Predictions from a stochastic polymer model for the MinDE protein dynamics in Escherichia coli. Phys Rev E Stat Nonlin Soft Matter Phys. 2009;80:041916 pubmed
    ..This solution gives a theoretical prediction of the distributions of both lengths of the polar MinD zones and periods of oscillations--both of which are experimentally measurable...
  52. de Boer P, Crossley R, Rothfield L. Roles of MinC and MinD in the site-specific septation block mediated by the MinCDE system of Escherichia coli. J Bacteriol. 1992;174:63-70 pubmed
    ..of potential division sites at the cell poles in a process that requires the coordinate action of the MinC, MinD, and MinE proteins...
  53. Norris V, Woldringh C, Mileykovskaya E. A hypothesis to explain division site selection in Escherichia coli by combining nucleoid occlusion and Min. FEBS Lett. 2004;561:3-10 pubmed
    ..of proteins into membrane (transertion), can structure the cytoplasmic membrane into phospholipid domains, (2) the MinD protein can convert vesicles into tubes and (3) a variety of membranous structures can be observed at mid-cell...
  54. Zhou H, Lutkenhaus J. The switch I and II regions of MinD are required for binding and activating MinC. J Bacteriol. 2004;186:1546-55 pubmed
    b>MinD and MinC cooperate to form an efficient inhibitor of Z-ring formation that is spatially regulated by MinE. MinD activates MinC by recruiting it to the membrane and targeting it to a septal component...
  55. Leipe D, Wolf Y, Koonin E, Aravind L. Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol. 2002;317:41-72 pubmed
    ..The second class, designated SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are ..
  56. Gerard E, Labedan B, Forterre P. Isolation of a minD-like gene in the hyperthermophilic archaeon Pyrococcus AL585, and phylogenetic characterization of related proteins in the three domains of life. Gene. 1998;222:99-106 pubmed
    ..This region contains an open reading frame (ORF) that encodes a polypeptide with a high similarity to MinD proteins and their Mrp paralogues...
  57. Cordell S, L we J. Crystal structure of the bacterial cell division regulator MinD. FEBS Lett. 2001;492:160-5 pubmed
    In bacterial cell division MinD plays a pivotal role, selecting the mid-cell over other sites. With MinC, MinD forms a non-specific inhibitor of division, that interacts with FtsZ...
  58. Johnson J, Lackner L, Hale C, de Boer P. ZipA is required for targeting of DMinC/DicB, but not DMinC/MinD, complexes to septal ring assemblies in Escherichia coli. J Bacteriol. 2004;186:2418-29 pubmed
    ..FtsZ assembly, while the C-terminal domain ((D)MinC) mediates both dimerization and complex formation with either MinD or DicB...
  59. Justice S, Garcia Lara J, Rothfield L. Cell division inhibitors SulA and MinC/MinD block septum formation at different steps in the assembly of the Escherichia coli division machinery. Mol Microbiol. 2000;37:410-23 pubmed
    ..These results indicate that MinCD blocks the assembly of the septation machinery at a later step than SulA, at the stage at which FtsA is added to the FtsZ ring. ..
  60. Ghosal D, Trambaiolo D, Amos L, Lowe J. MinCD cell division proteins form alternating copolymeric cytomotive filaments. Nat Commun. 2014;5:5341 pubmed publisher
    ..Its positioning is regulated by the oscillation of MinCDE proteins. MinC is activated by MinD through an unknown mechanism and prevents Z-ring assembly anywhere but midcell...
  61. de Boer P, Crossley R, Rothfield L. Isolation and properties of minB, a complex genetic locus involved in correct placement of the division site in Escherichia coli. J Bacteriol. 1988;170:2106-12 pubmed
    Mutation of Escherichia coli minicell locus (minB) results in aberrant placement of the division septum. In this paper we report the isolation and characterization of the minB locus...
  62. Lutkenhaus J. Min oscillation in bacteria. Adv Exp Med Biol. 2008;641:49-61 pubmed
    ..The simplicity and ease of manipulating the Min system make it a tractable model to obtain a complete understanding of a self-organizing system. ..
  63. Mazor S, Regev T, Mileykovskaya E, Margolin W, Dowhan W, Fishov I. Mutual effects of MinD-membrane interaction: II. Domain structure of the membrane enhances MinD binding. Biochim Biophys Acta. 2008;1778:2505-11 pubmed publisher
    b>MinD, a well-conserved bacterial amphitropic protein involved in spatial regulation of cell division, has a typical feature of reversible binding to the membrane...
  64. Nishiyama T, Sakemi H, Sumi H, Tokunaga S, Doi K, Ogata S. A chromosomal locus encoding a phosphoserine phosphatase- and a truncated MinD-like protein affects differentiation in Streptomyces azureus ATCC14921. FEMS Microbiol Lett. 2000;190:133-9 pubmed
    ..The deduced products were somewhat similar to phosphoserine phosphatase-like protein and the N-terminal region of MinD-like protein, respectively...
  65. Lutkenhaus J. Dynamic proteins in bacteria. Curr Opin Microbiol. 2002;5:548-52 pubmed
    ..to spatially regulate Z-ring assembly, has led to a biochemical basis for the oscillation and a suggestion that MinD assembles into dynamic filaments...
  66. Sakai N, Itou H, Watanabe N, Yao M, Tanaka I. The MinD protein from the hyperthermophilic archaeon Pyrococcus horikoshii: crystallization and preliminary X-ray analysis. Acta Crystallogr D Biol Crystallogr. 2001;57:896-7 pubmed
    b>MinD is one of the proteins regulating cell division. MinD from Escherichia coli has been designated as a type of motor protein which has an ATPase activity...
  67. Margolin W. Bacterial cell division: a moving MinE sweeper boggles the MinD. Curr Biol. 2001;11:R395-8 pubmed
    ..Recent studies have shown that MinE, previously thought to form a static ring near the division site at the midcell position, actually joins MinC and MinD in their rapid oscillation between the cell poles.
  68. Donachie W. Co-ordinate regulation of the Escherichia coli cell cycle or The cloud of unknowing. Mol Microbiol. 2001;40:779-85 pubmed
    ..A discussion of some aspects of the regulation of chromosome replication, segregation and cell division in Escherichia coli. ..
  69. Bignell C, Thomas C. The bacterial ParA-ParB partitioning proteins. J Biotechnol. 2001;91:1-34 pubmed
    ..In Bacillus subtilis ParA oscillates from end to end of the cell as does MinD of E. coli, a relative of the ParA family...
  70. Autret S, Errington J. Dynamic proteins in bacteria. Dev Cell. 2001;1:10-1 pubmed
    The MinCDE system regulates the position of the division plane in rod-shaped bacteria. New results from Escherichia coli provide insight into how this operates by showing that MinE stimulates the ATPase activity of MinD.
  71. Margolin W. Spatial regulation of cytokinesis in bacteria. Curr Opin Microbiol. 2001;4:647-52 pubmed
    ..This review summarizes and integrates these insights...
  72. Szeto J, Eng N, Acharya S, Rigden M, Dillon J. A conserved polar region in the cell division site determinant MinD is required for responding to MinE-induced oscillation but not for localization within coiled arrays. Res Microbiol. 2005;156:17-29 pubmed
    A region in the cell division site determinant MinD required for stimulation by MinE and which determines MinD topological specificity along coil-like structures has been identified...
  73. Marston A, Errington J. Selection of the midcell division site in Bacillus subtilis through MinD-dependent polar localization and activation of MinC. Mol Microbiol. 1999;33:84-96 pubmed
    ..Division site selection in rod-shaped bacteria is mediated by MinC and MinD, which form a division inhibitor...
  74. Sharp M, Pogliano K. MinCD-dependent regulation of the polarity of SpoIIIE assembly and DNA transfer. EMBO J. 2002;21:6267-74 pubmed
    ..Our results suggest that the ability of MinCD to sense positional information is utilized during sporulation to regulate protein assembly differentially on the two faces of the sporulation septum...
  75. Jaffe A, Boye E, D Ari R. Rule governing the division pattern in Escherichia coli minB and wild-type filaments. J Bacteriol. 1990;172:3500-2 pubmed
    Escherichia coli minB mutants form anucleate minicells and multinucleate filaments. We show here that the overwhelming majority of nucleate cells contain 2n (n = 0, 1, 2, .....
  76. Mulder E, El Bouhali M, Pas E, Woldringh C. The Escherichia coli minB mutation resembles gyrB in defective nucleoid segregation and decreased negative supercoiling of plasmids. Mol Gen Genet. 1990;221:87-93 pubmed
    Nucleoid segregation in the Escherichia coli minB mutant and in cells that over-produce minB gene products appeared defective as measured from fluorescence micrographs...