mgtA

Summary

Gene Symbol: mgtA
Description: magnesium transporter
Alias: ECK4237, JW4201, corB, mgt
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Montero M, Eydallin G, Viale A, Almagro G, Muñoz F, Rahimpour M, et al. Escherichia coli glycogen metabolism is controlled by the PhoP-PhoQ regulatory system at submillimolar environmental Mg2+ concentrations, and is highly interconnected with a wide variety of cellular processes. Biochem J. 2009;424:129-41 pubmed publisher
    ..Among the mutants identified in the study, Delta mgtA, Delta phoP and Delta phoQ cells, all lacking genes that are induced under low extracellular Mg2+ conditions, ..
  2. Groisman E, Cromie M, Shi Y, Latifi T. A Mg2+-responding RNA that controls the expression of a Mg2+ transporter. Cold Spring Harb Symp Quant Biol. 2006;71:251-8 pubmed
    ..We have determined that expression of the PhoP-activated Mg2+ transporter MgtA is also controlled by its 5'-untranslated region (5'UTR)...
  3. Cromie M, Shi Y, Latifi T, Groisman E. An RNA sensor for intracellular Mg(2+). Cell. 2006;125:71-84 pubmed
    ..We establish that expression of the Mg(2+) transporter MgtA of Salmonella enterica serovar Typhimurium is controlled by its 5' untranslated region (5'UTR)...
  4. Miyashiro T, Goulian M. Stimulus-dependent differential regulation in the Escherichia coli PhoQ PhoP system. Proc Natl Acad Sci U S A. 2007;104:16305-10 pubmed
  5. Yao J, Zhong J, Lambowitz A. Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Nucleic Acids Res. 2005;33:3351-62 pubmed
    ..All such introns tested individually gave the desired specific disruption, some by switching to an alternate retrohoming mechanism targeting single-stranded DNA and using a nascent lagging DNA strand to prime reverse transcription. ..
  6. Snavely M, Florer J, Miller C, Maguire M. Magnesium transport in Salmonella typhimurium: 28Mg2+ transport by the CorA, MgtA, and MgtB systems. J Bacteriol. 1989;171:4761-6 pubmed
    Three loci in Salmonella typhimurium (corA, mgtA, and mgtB) code for components of distinct Mg2+ transport systems (S. P. Hmiel, M. D. Snavely, J. B. Florer, M. E. Maguire, and C. G. Miller, J. Bacteriol. 171:4742-4751, 1989)...
  7. Spinelli S, Pontel L, García Véscovi E, Soncini F. Regulation of magnesium homeostasis in Salmonella: Mg(2+) targets the mgtA transcript for degradation by RNase E. FEMS Microbiol Lett. 2008;280:226-34 pubmed publisher
    ..One of the adaptive responses driven by PhoP/PhoQ includes the transcriptional induction of mgtA and mgtCB, which encode two P-type Mg(2+) transporters...
  8. Park M, Wong B, Lusk J. Mutants in three genes affecting transport of magnesium in Escherichia coli: genetics and physiology. J Bacteriol. 1976;126:1096-103 pubmed
    ..System I, for which Co2+, Mn2+, and Mg2+ are substrates, is inactive in corA mutants corB mutants express system I after growth on high (10 mM) Mg2+ but not low (0.1 mM) Mg2+...
  9. Yamamoto K, Ogasawara H, Fujita N, Utsumi R, Ishihama A. Novel mode of transcription regulation of divergently overlapping promoters by PhoP, the regulator of two-component system sensing external magnesium availability. Mol Microbiol. 2002;45:423-38 pubmed
    ..Here we demonstrate the mode of transcription regulation by phosphorylated PhoP of divergently transcribed mgtA and treR genes, each encoding a putative Mg(II) transporter and a repressor for the trehalose utilization operon ..

More Information

Publications18

  1. Subramani S, Perdreau Dahl H, Morth J. The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro. elife. 2016;5: pubmed publisher
    The magnesium transporter A (MgtA) is a specialized P-type ATPase, believed to import Mg(2+) into the cytoplasm...
  2. Minagawa S, Ogasawara H, Kato A, Yamamoto K, Eguchi Y, Oshima T, et al. Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli. J Bacteriol. 2003;185:3696-702 pubmed
    ..verify six new Mg(2+) stimulon genes, hemL, nagA, rstAB, slyB, vboR, and yrbL, in addition to the phoPQ, mgrB, and mgtA genes reported previously...
  3. Hakansson K. The structure of Mg-ATPase nucleotide-binding domain at 1.6 A resolution reveals a unique ATP-binding motif. Acta Crystallogr D Biol Crystallogr. 2009;65:1181-6 pubmed publisher
    The structure of the nucleotide-binding domain of the Mg-ATPase MgtA from Escherichia coli has been solved and refined to 1.6 A resolution...
  4. Minagawa S, Okura R, Tsuchitani H, Hirao K, Yamamoto K, Utsumi R. Isolation and molecular characterization of the locked-on mutant of Mg2+ sensor PhoQ in Escherichia coli. Biosci Biotechnol Biochem. 2005;69:1281-7 pubmed
    ..PhoQ-PhoP regulon genes, phoPQ, mgtA and mgrB transcriptions were repressed at a high Mg(2+) concentration in WQ3007 (phoQ-defective strain)/pHO119, but ..
  5. Webb M. The mechanism of acquired resistance to Co2+ and Ni2+ in Gram-positive and Gram-negative bacteria. Biochim Biophys Acta. 1970;222:440-6 pubmed
  6. Sermon J, Vanoirbeek K, De Spiegeleer P, Van Houdt R, Aertsen A, Michiels C. Unique stress response to the lactoperoxidase-thiocyanate enzyme system in Escherichia coli. Res Microbiol. 2005;156:225-32 pubmed
    ..Several of the induced genes or pathways may be involved in bacterial defense against the toxic effects of the lactoperoxidase-thiocyanate enzyme system. ..
  7. Eguchi Y, Okada T, Minagawa S, Oshima T, Mori H, Yamamoto K, et al. Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli. J Bacteriol. 2004;186:3006-14 pubmed
    ..system of Escherichia coli resulted in enhanced expression of 13 PhoP/PhoQ-regulated genes, crcA, hemL, mgtA, ompT, phoP, phoQ, proP, rstA, rstB, slyB, ybjG, yrbL, and mgrB...
  8. Kato A, Tanabe H, Utsumi R. Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters. J Bacteriol. 1999;181:5516-20 pubmed
    We identified Mg2+-responsive promoters of the phoPQ, mgtA, and mgrB genes of Escherichia coli K-12 by S1 nuclease analysis. Expression of these genes was induced by magnesium limitation and depended on PhoP and PhoQ...
  9. Smith R, Maguire M. Microbial magnesium transport: unusual transporters searching for identity. Mol Microbiol. 1998;28:217-26 pubmed
    ..MgtE also lacks homology to other known proteins. In contrast, the MgtA and MgtB Mg2+ transport systems of enteric bacteria are P-type ATPases by sequence homology, mediating Mg2+ influx ..