Gene Symbol: mgrB
Description: regulatory peptide for PhoPQ, feedback inhibition
Alias: ECK1824, JW1815, yobG
Species: Escherichia coli str. K-12 substr. MG1655
Kato A, Tanabe H, Utsumi R. Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters. J Bacteriol. 1999;181:5516-20 pubmed
We identified Mg2+-responsive promoters of the phoPQ, mgtA, and mgrB genes of Escherichia coli K-12 by S1 nuclease analysis. Expression of these genes was induced by magnesium limitation and depended on PhoP and PhoQ...
Minagawa S, Ogasawara H, Kato A, Yamamoto K, Eguchi Y, Oshima T, et al
. Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli. J Bacteriol. 2003;185:3696-702 pubmed
..to verify six new Mg(2+) stimulon genes, hemL, nagA, rstAB, slyB, vboR, and yrbL, in addition to the phoPQ, mgrB, and mgtA genes reported previously...
Miyashiro T, Goulian M. Stimulus-dependent differential regulation in the Escherichia coli PhoQ PhoP system. Proc Natl Acad Sci U S A. 2007;104:16305-10 pubmed
Lippa A, Goulian M. Feedback inhibition in the PhoQ/PhoP signaling system by a membrane peptide. PLoS Genet. 2009;5:e1000788 pubmed publisher
..We found that deletion of mgrB (yobG), which encodes a 47 amino acid peptide, results in a potent increase in PhoP-regulated transcription...
Eguchi Y, Okada T, Minagawa S, Oshima T, Mori H, Yamamoto K, et al
. Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli. J Bacteriol. 2004;186:3006-14 pubmed
..of 13 PhoP/PhoQ-regulated genes, crcA, hemL, mgtA, ompT, phoP, phoQ, proP, rstA, rstB, slyB, ybjG, yrbL, and mgrB. This regulatory network between the two systems also occurred as a result of overproduction of the EvgA regulator; ..
Hobbs E, Astarita J, Storz G. Small RNAs and small proteins involved in resistance to cell envelope stress and acid shock in Escherichia coli: analysis of a bar-coded mutant collection. J Bacteriol. 2010;192:59-67 pubmed publisher
..Deletion mutants of genes coding for four small proteins (yqgB, mgrB, yobF, and yceO) were sensitive to acute acid stress...
Minagawa S, Okura R, Tsuchitani H, Hirao K, Yamamoto K, Utsumi R. Isolation and molecular characterization of the locked-on mutant of Mg2+ sensor PhoQ in Escherichia coli. Biosci Biotechnol Biochem. 2005;69:1281-7 pubmed
..PhoQ-PhoP regulon genes, phoPQ, mgtA and mgrB transcriptions were repressed at a high Mg(2+) concentration in WQ3007 (phoQ-defective strain)/pHO119, but not in ..
Lippa A, Goulian M. Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli. J Bacteriol. 2012;194:1457-63 pubmed publisher
..histidine kinase PhoQ is also modulated by at least two additional factors, the small membrane proteins SafA and MgrB. This raises the possibility that the PhoQ/PhoP circuit has additional regulatory components and integrates ..