Gene Symbol: mdtM
Description: multidrug efflux system protein
Alias: ECK4328, JW4300, yjiO
Species: Escherichia coli str. K-12 substr. MG1655
Tal N, Schuldiner S. A coordinated network of transporters with overlapping specificities provides a robust survival strategy. Proc Natl Acad Sci U S A. 2009;106:9051-6 pubmed publisher
..This strategy also confers evolvability to the organism by reducing constraints on change and allowing the accumulation of nonlethal variation. ..
Holdsworth S, Law C. Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli. BMC Microbiol. 2013;13:113 pubmed publisher
..We hypothesised that the multidrug resistance protein MdtM, a recently characterised homologue of MdfA and a member of the major facilitator superfamily, also functions in ..
Edgar R, Bibi E. MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. J Bacteriol. 1997;179:2274-80 pubmed
..Transport experiments with an E. coli strain lacking F1-F0 proton ATPase activity indicate that MdfA is a multidrug transporter that is driven by the proton electrochemical gradient. ..
Holdsworth S, Law C. Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM. Biochimie. 2012;94:1334-46 pubmed publisher
..We characterised and purified the putative Escherichia coli MDR transporter, MdtM, a 410 amino acid residue protein that belongs to the large and ubiquitous major facilitator superfamily...
Krizsan A, Knappe D, Hoffmann R. Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System. Antimicrob Agents Chemother. 2015;59:5992-8 pubmed publisher
..In a second round of random mutagenesis, the remaining susceptibility was linked to the yjiL-mdtM gene cluster. E...
Paulsen I, Nguyen L, Sliwinski M, Rabus R, Saier M. Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. J Mol Biol. 2000;301:75-100 pubmed
..Archaea and spirochetes exhibit fewer proteins with multiple transmembrane segments and fewer net transporters than most bacteria. These results provide insight into the relevance of transport to the overall physiology of prokaryotes. ..
Paul S, Alegre K, Holdsworth S, Rice M, Brown J, McVeigh P, et al
. A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress. Mol Microbiol. 2014;92:872-84 pubmed publisher
..2 and 6.0) that reflect pH conditions that E.?coli may encounter in human gut that MdtM, a single-component multidrug resistance transporter of the major facilitator superfamily, functions in bile salt ..