Gene Symbol: mcbR
Description: colanic acid and biofilm gene transcriptional regulator, MqsR-controlled
Alias: ECK1444, JW1445, yncC
Species: Escherichia coli str. K-12 substr. MG1655
Ibanez Ruiz M, Robbe Saule V, Hermant D, Labrude S, Norel F. Identification of RpoS (sigma(S))-regulated genes in Salmonella enterica serovar typhimurium. J Bacteriol. 2000;182:5749-56 pubmed
..Ten insertions mapped in nine open reading frames of unknown function (yciF, yehY, yhjY, yncC, yjgB, yahO, ygaU, ycgB, and yeaG) appear to be novel members of the RpoS regulon...
Xu Y, Heath R, Li Z, Rock C, White S. The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli. J Biol Chem. 2001;276:17373-9 pubmed
..We suggest that the binding of acyl-CoA disrupts a buried network of charged and polar residues in the C-terminal domain, and the resulting conformational change is transmitted to the N-terminal domain via a domain-spanning alpha-helix. ..
Rudd K, Humphery Smith I, Wasinger V, Bairoch A. Low molecular weight proteins: a challenge for post-genomic research. Electrophoresis. 1998;19:536-44 pubmed publisher
..The problem of accurate protein sequence identification is not limited to small proteins or to E. coli; these problems are encountered to varying degrees throughout all sequence databases...
Rigali S, Derouaux A, Giannotta F, Dusart J. Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies. J Biol Chem. 2002;277:12507-15 pubmed
..The observed C-terminal E-b/O domain heterogeneity was therefore reflected on the DNA-binding domain and on the cis-acting elements, suggesting the existence of a tight link between the three regions involved in the regulating process. ..
Zhang X, García Contreras R, Wood T. Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA). ISME J. 2008;2:615-31 pubmed publisher
..through the motility regulator MqsR that induces expression of the putative transcription factor encoded by yncC. Here, we show that YncC increases biofilm formation by repressing overproduction of the exopolysaccharide ..
Hoskisson P, Rigali S. Chapter 1: Variation in form and function the helix-turn-helix regulators of the GntR superfamily. Adv Appl Microbiol. 2009;69:1-22 pubmed publisher
..This review summarises what we know about the distribution, structure, function and classification of these regulators and suggests that they may have a future role in biotechnology. ..