Gene Symbol: malI
Description: transcriptional repressor of Mal regulon
Alias: ECK1615, JW1612
Species: Escherichia coli str. K-12 substr. MG1655
Reidl J, Boos W. The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system. J Bacteriol. 1991;173:4862-76 pubmed
..A second site mutation in malI abolishes the constitutive expression...
Reidl J, Römisch K, Ehrmann M, Boos W. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI. J Bacteriol. 1989;171:4888-99 pubmed
..For this constitutivity to be exerted, the function of an additional gene product, MalI, is necessary...
Ehrmann M, Boos W. Identification of endogenous inducers of the mal regulon in Escherichia coli. J Bacteriol. 1987;169:3539-45 pubmed
..We isolated a mutant that no longer synthesized this oligosaccharide. The gene carrying this mutation, termed malI, was mapped at min 36 on the E. coli linkage map...
Wick L, Quadroni M, Egli T. Short- and long-term changes in proteome composition and kinetic properties in a culture of Escherichia coli during transition from glucose-excess to glucose-limited growth conditions in continuous culture and vice versa. Environ Microbiol. 2001;3:588-99 pubmed
..continuous culture showed a highly increased expression of MglB and MalE as well as of the regulator protein MalI. When adapted cells taken from the "500-h-old" continuous culture were transferred to batch culture, an ..
Lloyd G, Hollands K, Godfrey R, Busby S. Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein. FEMS Microbiol Lett. 2008;288:250-7 pubmed publisher
The Escherichia coli K-12 malI-malX intergenic region contains two divergent promoters, which have been investigated by both mutational and biochemical analysis...
Swint Kruse L, Matthews K. Allostery in the LacI/GalR family: variations on a theme. Curr Opin Microbiol. 2009;12:129-37 pubmed publisher
..In turn, binding to alternative DNA sequences may impact the degree of allosteric response. Thus, this family exhibits a symphony of variations by which transcriptional control is achieved. ..
Mitchell A, Romano G, Groisman B, Yona A, Dekel E, Kupiec M, et al
. Adaptive prediction of environmental changes by microorganisms. Nature. 2009;460:220-4 pubmed publisher
..Our work indicates that environmental anticipation is an adaptive trait that was repeatedly selected for during evolution and thus may be ubiquitous in biology. ..
Lloyd G, Godfrey R, Busby S. Targets for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters. FEMS Microbiol Lett. 2010;305:28-34 pubmed publisher
Random mutagenesis has been used to identify the target DNA sites for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters...