Gene Symbol: mak
Description: manno(fructo)kinase
Alias: ECK0389, JW0385, yajF
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Reeder T, Schleif R. Mapping, sequence, and apparent lack of function of araJ, a gene of the Escherichia coli arabinose regulon. J Bacteriol. 1991;173:7765-71 pubmed
    ..S. Naom, S. J. Morton, D. R. F. Leach, and R. G. Lloyd, Nucleic Acids Res. 17:8033-8044, 1989). The carboxyl region of SbcC has an amino acid sequence consistent with this region of SbcC forming an extended alpha-helical coiled-coil. ..
  2. Kornberg H, Lambourne L, Sproul A. Facilitated diffusion of fructose via the phosphoenolpyruvate/glucose phosphotransferase system of Escherichia coli. Proc Natl Acad Sci U S A. 2000;97:1808-12 pubmed
    ..thus taken into the cells is phosphorylated to fructose 6-phosphate by ATP and a cytosolic fructo(manno)kinase (Mak)...
  3. Kornberg H. Routes for fructose utilization by Escherichia coli. J Mol Microbiol Biotechnol. 2001;3:355-9 pubmed
    ..PTS and is then phosphorylated by ATP and a manno(fructo)kinase (Mak+) specified by a normally cryptic 1032 bp ORF (yajF) of hitherto unknown function (Mak-o), mapping at min. 8.8 and corresponding to a peptide of 344 amino acids...
  4. Miller B, Raines R. Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry. 2005;44:10776-83 pubmed
    ..G., and Raines, R. T. (2004) Biochemistry 43, 6387-6392]. These catalysts are the YajF, YcfX, and NanK polypeptides, all of which possess rudimentary glucokinase activities...
  5. Sproul A, Lambourne L, Jean Jacques D J, Kornberg H. Genetic control of manno(fructo)kinase activity in Escherichia coli. Proc Natl Acad Sci U S A. 2001;98:15257-9 pubmed
    ..The mak gene was located at min 8.8 on the E. coli linkage map as an ORF designated yajF, of hitherto unknown function; it specifies a deduced polypeptide of 344 aa...
  6. Miller B, Raines R. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Biochemistry. 2004;43:6387-92 pubmed
    ..These sequences contain the nanK, yajF, and ycfX genes...