lysR

Summary

Gene Symbol: lysR
Description: transcriptional activator of lysA; autorepressor
Alias: ECK2837, JW2807
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Stragier P, Richaud F, Borne F, Patte J. Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. I. Identification of a lysR gene encoding an activator of the lysA gene. J Mol Biol. 1983;168:307-20 pubmed
    ..by mutations in two different and closely linked loci: one being the lysA structural gene, and the other called lysR. We propose that the lysR gene encodes a positive effector required for the full expression of the lysA gene...
  2. Schell M. Molecular biology of the LysR family of transcriptional regulators. Annu Rev Microbiol. 1993;47:597-626 pubmed
    The LysR family is composed of > 50 similar-sized, autoregulatory transcriptional regulators (LTTRs) that apparently evolved from a distant ancestor into subfamilies found in diverse prokaryotic genera...
  3. Henikoff S, Haughn G, Calvo J, Wallace J. A large family of bacterial activator proteins. Proc Natl Acad Sci U S A. 1988;85:6602-6 pubmed
    At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here...
  4. Maddocks S, Oyston P. Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins. Microbiology. 2008;154:3609-23 pubmed publisher
    The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom...
  5. Stragier P, Borne F, Richaud F, Richaud C, Patte J. Regulatory pattern of the Escherichia coli lysA gene: expression of chromosomal lysA-lacZ fusions. J Bacteriol. 1983;156:1198-203 pubmed
    ..Our results indicate an absolute requirement for the LysR product for its activation, LysR protein present in a limiting amount which can be titrated by a multicopy plasmid ..
  6. Knapp G, Hu J. Specificity of the E. coli LysR-type transcriptional regulators. PLoS ONE. 2010;5:e15189 pubmed publisher
    ..How the specificity of assembly evolves is a fundamental question of biology. The LysR-Type Transcriptional Regulators (LTTR) form perhaps the largest family of transcriptional regulators in bacteria...
  7. Maiden M, Jones Mortimer M, Henderson P. The cloning, DNA sequence, and overexpression of the gene araE coding for arabinose-proton symport in Escherichia coli K12. J Biol Chem. 1988;263:8003-10 pubmed
    ..coli genome to establish the gene order thyA araE orf lysR lysA galR; araE was transcribed toward orf. A 4...
  8. Stragier P, Danos O, Patte J. Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. II. Nucleotide sequence of the lysA gene and its regulatory region. J Mol Biol. 1983;168:321-31 pubmed
    ..No attenuation-like sequence was found at the beginning of the lysA gene. A target of the LysR activator protein was localized on a 73 base-pair fragment found 48 base-pairs upstream from the lysA coding region...
  9. Stragier P, Patte J. Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. III. Nucleotide sequence and regulation of the lysR gene. J Mol Biol. 1983;168:333-50 pubmed
    The complete nucleotide sequence of the lysR gene, which encodes the activatory protein required for lysA expression, has been determined...