Gene Symbol: lsrR
Description: lsr operon transcriptional repressor
Alias: ECK1505, JW1505, ydeW
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Xavier K, Bassler B. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol. 2005;187:238-48 pubmed
    ..accumulates in the glpD mutant, and DHAP represses lsr transcription by a cAMP-CAP-independent mechanism involving LsrR, the lsr operon repressor...
  2. Wang L, Li J, March J, Valdes J, Bentley W. luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling. J Bacteriol. 2005;187:8350-60 pubmed
    ..Under the latter condition, the metE gene, the lsrACDBFG operon, and the flanking genes of the lsr operon (lsrR, lsrK, tam, and yneE) were among the most significantly induced genes by luxS. The E...
  3. Walters M, Sircili M, Sperandio V. AI-3 synthesis is not dependent on luxS in Escherichia coli. J Bacteriol. 2006;188:5668-81 pubmed
    ..This study examines how AI-3 production is affected by the luxS mutation and explores the roles of the LuxS/AI-2 system in metabolism and QS. ..
  4. Xavier K, Miller S, Lu W, Kim J, Rabinowitz J, Pelczer I, et al. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem Biol. 2007;2:128-36 pubmed
    ..Phosphorylated DPD (P-DPD) binds specifically to the repressor of the lsr operon, LsrR, consistent with P-DPD being the inducer of the lsr operon...
  5. Ahmer B. Cell-to-cell signalling in Escherichia coli and Salmonella enterica. Mol Microbiol. 2004;52:933-45 pubmed
    ..The latter system has homologues in E. coli and Salmonella, as well as other bacteria, plants and animals. In fact, the protease components from Providencia and Drosophila are functionally interchangeable. ..
  6. Xavier K, Bassler B. Interference with AI-2-mediated bacterial cell-cell communication. Nature. 2005;437:750-3 pubmed
    ..AI-2 signalling, and the interference with it, could have important ramifications for eukaryotes in the maintenance of normal microflora and in protection from pathogenic bacteria. ..
  7. Li J, Attila C, Wang L, Wood T, Valdes J, Bentley W. Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture. J Bacteriol. 2007;189:6011-20 pubmed
    ..the uptake of Escherichia coli autoinducer 2 (AI-2) is comprised of a transporter complex, LsrABCD; its repressor, LsrR; and a cognate signal kinase, LsrK. This network is an integral part of the AI-2 quorum-sensing (QS) system...
  8. Zhang X, GarcĂ­a Contreras R, Wood T. Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA). ISME J. 2008;2:615-31 pubmed publisher
    ..Overexpressing MqsR, AI-2 import regulators LsrR/LsrK and AI-2 exporter TqsA induced yncC transcription, whereas the AI-2 synthase LuxS and B3023 repressed yncC...
  9. Gonzalez Barrios A, Achenie L. Escherichia coli autoinducer-2 uptake network does not display hysteretic behavior but AI-2 synthesis rate controls transient bifurcation. Biosystems. 2010;99:17-26 pubmed publisher
    ..b>LsrR inactivation was found to play a crucial role in the uptake activation compared to AI-2 synthesis, lsr ..

More Information


  1. Fuqua W, Winans S, Greenberg E. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol. 1994;176:269-75 pubmed
  2. Taga M, Semmelhack J, Bassler B. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol. 2001;42:777-93 pubmed
    ..This gene, which we have named lsrR, encodes a protein that represses lsr operon expression in the absence of AI-2...
  3. Wang L, Hashimoto Y, Tsao C, Valdes J, Bentley W. Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli. J Bacteriol. 2005;187:2066-76 pubmed shown to bind to a CRP binding site located in the upstream region of the lsr promoter and works with the LsrR repressor to regulate AI-2 uptake...
  4. Xue T, Zhao L, Sun H, Zhou X, Sun B. LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Cell Res. 2009;19:1258-68 pubmed publisher
    ..Upstream of the lsr operon, there is a divergently transcribed gene encoding LsrR, which was reported previously to repress the transcription of the lsr operon and itself...
  5. Taga M, Miller S, Bassler B. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Mol Microbiol. 2003;50:1411-27 pubmed
    ..We suggest that phospho-AI-2 is the inducer responsible for inactivation of LsrR, the repressor of the lsr operon...
  6. Wu M, Tao Y, Liu X, Zang J. Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli. J Biol Chem. 2013;288:15878-87 pubmed publisher
    ..In Escherichia coli, LsrR serves as a global transcription regulator that responds to autoinducer-2 to regulate the expression of a variety ..