Gene Symbol: lsrG
Description: autoinducer-2 (AI-2) degrading protein LsrG
Alias: ECK1511, JW1511, yneC
Species: Escherichia coli str. K-12 substr. MG1655
Marques J, Lamosa P, Russell C, Ventura R, Maycock C, Semmelhack M, et al
. Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. J Biol Chem. 2011;286:18331-43 pubmed publisher
..facilitates uptake of the signal, a kinase that phosphorylates the signal to phospho-DPD (P-DPD), and enzymes (like LsrG) that are responsible for processing the phosphorylated signal...
Taga M, Semmelhack J, Bassler B. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol. 2001;42:777-93 pubmed
..It is intriguing that an operon regulated by AI-2 encodes functions resembling the ribose transporter, given recent findings that AI-2 is derived from the ribosyl moiety of S-ribosylhomocysteine...
Wang L, Hashimoto Y, Tsao C, Valdes J, Bentley W. Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli. J Bacteriol. 2005;187:2066-76 pubmed
..coli. The elucidation of cAMP-CRP involvement in E. coli autoinduction impacts many areas, including the growth of E. coli in fermentation processes. ..
Wang L, Li J, March J, Valdes J, Bentley W. luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling. J Bacteriol. 2005;187:8350-60 pubmed
..These data are consistent with the function of LuxS as an important metabolic enzyme but appear not to support the role of AI-2 as a true signal molecule for E. coli W3110 under the investigated conditions. ..
Taga M, Miller S, Bassler B. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Mol Microbiol. 2003;50:1411-27 pubmed
..We also show that two previously uncharacterized members of the lsr operon, LsrF and LsrG, are necessary for the further processing of phospho-AI-2...
Xavier K, Bassler B. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol. 2005;187:238-48 pubmed
..These findings show that, depending on the prevailing growth conditions, the amount of time that the AI-2 signal is present and, in turn, the time that a given community of bacteria remains exposed to this signal can vary greatly. ..
Xavier K, Miller S, Lu W, Kim J, Rabinowitz J, Pelczer I, et al
. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem Biol. 2007;2:128-36 pubmed
..Subsequently, LsrG catalyzes the cleavage of P-DPD producing 2-phosphoglycolic acid...