lrp

Summary

Gene Symbol: lrp
Description: leucine-responsive global transcriptional regulator
Alias: ECK0880, JW0872, alsB, ihb, livR, lrs, lss, lstR, mbf, oppI, rblA
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Chen S, Calvo J. Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers. J Mol Biol. 2002;318:1031-42 pubmed
    b>Lrp is a global regulator of metabolism in Escherichia coli that helps cells respond to changes in environmental conditions...
  2. Ernsting B, Atkinson M, Ninfa A, Matthews R. Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. J Bacteriol. 1992;174:1109-18 pubmed
    The leucine-responsive regulatory protein (Lrp) has been shown to regulate, either positively or negatively, the transcription of several Escherichia coli genes in response to leucine...
  3. Zinser E, Kolter R. Prolonged stationary-phase incubation selects for lrp mutations in Escherichia coli K-12. J Bacteriol. 2000;182:4361-5 pubmed
    ..A. Almirón, A. Tormo, and R. Kolter, Science 259:1757-1760, 1993). We now report that a second global regulator, Lrp, can also play a role in stationary-phase competition...
  4. Chen C, Newman E. Comparison of the sensitivities of two Escherichia coli genes to in vivo variation of Lrp concentration. J Bacteriol. 1998;180:655-9 pubmed
    Transcription of the Escherichia coli genes serA and gltBDF depends on the leucine-responsive regulatory protein, Lrp, and is very much decreased in an lrp mutant...
  5. Haney S, Platko J, Oxender D, Calvo J. Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli. J Bacteriol. 1992;174:108-15 pubmed
    We investigated the relationship between two regulatory genes, livR and lrp, that map near min 20 on the Escherichia coli chromosome...
  6. Ernsting B, Denninger J, Blumenthal R, Matthews R. Regulation of the gltBDF operon of Escherichia coli: how is a leucine-insensitive operon regulated by the leucine-responsive regulatory protein?. J Bacteriol. 1993;175:7160-9 pubmed
    The regulon controlled by the leucine-responsive regulatory protein (Lrp) of Escherichia coli consists of over 40 genes and proteins whose expression is regulated, either positively or negatively, by Lrp...
  7. Paul L, Blumenthal R, Matthews R. Activation from a distance: roles of Lrp and integration host factor in transcriptional activation of gltBDF. J Bacteriol. 2001;183:3910-8 pubmed
    The leucine-responsive regulatory protein (Lrp) binds to three sites centered 252, 216, and 152 bp upstream of the transcription start site of the Escherichia coli glutamate synthase operon (gltBDF) and activates transcription...
  8. Rhee K, Parekh B, Hatfield G. Leucine-responsive regulatory protein-DNA interactions in the leader region of the ilvGMEDA operon of Escherichia coli. J Biol Chem. 1996;271:26499-507 pubmed
    The leucine-responsive regulatory protein (Lrp) regulates the expression of many operons in Escherichia coli including several involved in the metabolism of the branched-chain amino acids, L-isoleucine, L-valine, and L-leucine...
  9. Landini P, Hajec L, Nguyen L, Burgess R, Volkert M. The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene. Mol Microbiol. 1996;20:947-55 pubmed
    ..transcription of aidB is inhibited both in vitro and in vivo by binding of the transcriptional regulator Lrp (leucine responsive protein) to the aidB promoter region (PaidB)...

More Information

Publications72

  1. Brinkman A, Ettema T, de Vos W, van der Oost J. The Lrp family of transcriptional regulators. Mol Microbiol. 2003;48:287-94 pubmed
    Genome analysis has revealed that members of the Lrp family of transcriptional regulators are widely distributed among prokaryotes, both bacteria and archaea...
  2. Calvo J, Matthews R. The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli. Microbiol Rev. 1994;58:466-90 pubmed
    The leucine-responsive regulatory protein (Lrp) regulates the expression of more than 40 genes and proteins in Escherichia coli...
  3. Chen S, Rosner M, Calvo J. Leucine-regulated self-association of leucine-responsive regulatory protein (Lrp) from Escherichia coli. J Mol Biol. 2001;312:625-35 pubmed
    b>Lrp is a global regulatory protein in Escherichia coli that activates expression of more than a dozen operons and represses expression of another dozen...
  4. Ali Azam T, Iwata A, Nishimura A, Ueda S, Ishihama A. Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid. J Bacteriol. 1999;181:6361-70 pubmed
    ..HU (heat-unstable nucleoid protein), IciA (inhibitor of chromosome initiation A), IHF (integration host factor), Lrp (leucine-responsive regulatory protein), and StpA (suppressor of td mutant phenotype A)...
  5. Peterson S, Dahlquist F, Reich N. The role of high affinity non-specific DNA binding by Lrp in transcriptional regulation and DNA organization. J Mol Biol. 2007;369:1307-17 pubmed
    ..Here we show that the bacterial leucine-responsive regulatory protein (Lrp) does not follow this trend and has a approximately 20-400-fold binding discrimination between specific and non-..
  6. Willins D, Ryan C, Platko J, Calvo J. Characterization of Lrp, and Escherichia coli regulatory protein that mediates a global response to leucine. J Biol Chem. 1991;266:10768-74 pubmed
    ..For at least some of these operons, the leucine-related effect is mediated by a protein called Lrp (Leucine-responsive regulatory protein). The purification of Lrp to near homogeneity is described...
  7. Thaw P, Sedelnikova S, Muranova T, Wiese S, Ayora S, Alonso J, et al. Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family. Nucleic Acids Res. 2006;34:1439-49 pubmed publisher
    The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria...
  8. Platko J, Calvo J. Mutations affecting the ability of Escherichia coli Lrp to bind DNA, activate transcription, or respond to leucine. J Bacteriol. 1993;175:1110-7 pubmed
    b>Lrp is a regulatory protein in Escherichia coli that increases expression of some operons and decreases expression of others...
  9. Platko J, Willins D, Calvo J. The ilvIH operon of Escherichia coli is positively regulated. J Bacteriol. 1990;172:4563-70 pubmed
    ..The ihb gene is identical to oppI, a gene that regulates the oppABCDF operon (E. A. Austin, J. C. Andrews, and S. A. Short, Abstr. Mol. Genet...
  10. Tani T, Khodursky A, Blumenthal R, Brown P, Matthews R. Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc Natl Acad Sci U S A. 2002;99:13471-6 pubmed
    ..There is evidence that the leucine-responsive regulatory protein (Lrp) may play an important role in stationary phase, so this study used microarrays representing >98% of E...
  11. Newman E, Lin R. Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli. Annu Rev Microbiol. 1995;49:747-75 pubmed
    The leucine-responsive regulatory protein (Lrp) regulates transcription of the many genes of the Lrp regulon, repressing some and activating others, some in response to L-leucine and some independent of it...
  12. D Ari R, Lin R, Newman E. The leucine-responsive regulatory protein: more than a regulator?. Trends Biochem Sci. 1993;18:260-3 pubmed
    The leucine-responsive regulatory protein (Lrp) is the regulator of the recently discovered leucine/Lrp regulon in Escherichia coli. Like other global regulators, it regulates the expression of 35 or more specific target operons...
  13. Paul L, Mishra P, Blumenthal R, Matthews R. Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR. BMC Microbiol. 2007;7:2 pubmed
    ..coli genes, two were previously shown to exert direct, positive control on gltBDF transcription: Lrp and IHF...
  14. Friedberg D, Platko J, Tyler B, Calvo J. The amino acid sequence of Lrp is highly conserved in four enteric microorganisms. J Bacteriol. 1995;177:1624-6 pubmed
    b>Lrp (leucine-responsive regulatory protein) is a global regulator of metabolism in Escherichia coli (J. M. Calvo and R. G. Matthews, Microbiol. Rev. 58:466-490, 1994)...
  15. Azam T, Ishihama A. Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J Biol Chem. 1999;274:33105-13 pubmed
    ..HU (heat-unstable nucleoid protein), IciA (inhibitor of chromosome initiation A), IHF (integration host factor), Lrp (leucine-responsive regulatory protein), and StpA (suppressor of td(-) phenotype A)...
  16. De Los Rios S, Perona J. Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly. J Mol Biol. 2007;366:1589-602 pubmed
    The structure of Escherichia coli leucine-responsive regulatory protein (Lrp) co-crystallized with a short duplex oligodeoxynucleotide reveals a novel quaternary assembly in which the protein octamer forms an open, linear array of four ..
  17. Lin R, Ernsting B, Hirshfield I, Matthews R, Neidhardt F, Clark R, et al. The lrp gene product regulates expression of lysU in Escherichia coli K-12. J Bacteriol. 1992;174:2779-84 pubmed
    In Escherichia coli K-12, expression of the lysU gene is regulated by the lrp gene product, as indicated by an increase in the level of lysyl-tRNA synthetase activity and LysU protein in an lrp mutant...
  18. Wang Q, Wu J, Friedberg D, Plakto J, Calvo J. Regulation of the Escherichia coli lrp gene. J Bacteriol. 1994;176:1831-9 pubmed
    b>Lrp (leucine-responsive regulatory protein) is a major Escherichia coli regulatory protein which regulates expression of a number of operons, some negatively and some positively...
  19. Hung S, Baldi P, Hatfield G. Global gene expression profiling in Escherichia coli K12. The effects of leucine-responsive regulatory protein. J Biol Chem. 2002;277:40309-23 pubmed
    Leucine-responsive regulatory protein (Lrp) is a global regulatory protein that affects the expression of multiple genes and operons in bacteria...
  20. Colland F, Barth M, Hengge Aronis R, Kolb A. sigma factor selectivity of Escherichia coli RNA polymerase: role for CRP, IHF and lrp transcription factors. EMBO J. 2000;19:3028-37 pubmed
    ..The cAMP receptor protein (CRP) bound to cAMP, the leucine-responsive regulatory protein (Lrp) and the integration host factor (IHF) inhibit transcription initiation at the osmY promoter...
  21. Pul U, Wurm R, Wagner R. The role of LRP and H-NS in transcription regulation: involvement of synergism, allostery and macromolecular crowding. J Mol Biol. 2007;366:900-15 pubmed
    b>LRP has recently been shown to interact with the regulatory regions of bacterial ribosomal RNA promoters. Here we study details of the LRP-rDNA interaction by gel retardation and high-resolution footprinting techniques...
  22. Luijsterburg M, Noom M, Wuite G, Dame R. The architectural role of nucleoid-associated proteins in the organization of bacterial chromatin: a molecular perspective. J Struct Biol. 2006;156:262-72 pubmed
    ..In this review, we provide an overview of the major nucleoid-associated proteins from a structural perspective and we discuss their possible roles in dynamically shaping the bacterial nucleoid. ..
  23. Ruiz J, Haneburger I, Jung K. Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli. J Bacteriol. 2011;193:2536-48 pubmed publisher
    ..S. Laishram and J. Gowrishankar, Genes Dev. 21:1258-1272, 2007). The global regulator Lrp also bound to the lysP promoter/control region...
  24. Smith D, Stine W, Svitil A, Bakker A, Zyskind J. Escherichia coli cells lacking methylation-blocking factor (leucine-responsive regulatory protein) have precise timing of initiation of DNA replication in the cell cycle. J Bacteriol. 1992;174:3078-82 pubmed
    ..methylation inhibition of two GATC sites in the papBA pilin promoter region, known as methylation-blocking factor (Mbf) and recently shown to be identical to the leucine-responsive regulatory protein (Lrp), is not responsible for the ..
  25. Grant G. The ACT domain: a small molecule binding domain and its role as a common regulatory element. J Biol Chem. 2006;281:33825-9 pubmed
  26. Lin R, D Ari R, Newman E. Lambda placMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine. J Bacteriol. 1992;174:1948-55 pubmed
    ..of several Escherichia coli genes according to the presence of exogenous leucine, which interacts with the lrp gene product, Lrp. We isolated and characterized 22 strains with lambda placMu insertions in Lrp-regulated genes...
  27. Chen S, Hao Z, Bieniek E, Calvo J. Modulation of Lrp action in Escherichia coli by leucine: effects on non-specific binding of Lrp to DNA. J Mol Biol. 2001;314:1067-75 pubmed
    b>Lrp is a global regulator of metabolism in Escherichia coli that helps cells respond to changes in environmental conditions...
  28. Free A, Dorman C. The Escherichia coli stpA gene is transiently expressed during growth in rich medium and is induced in minimal medium and by stress conditions. J Bacteriol. 1997;179:909-18 pubmed
    ..we observe a more sustained induction of stpA which is dependent on the leucine-responsive regulatory protein (Lrp)...
  29. Braaten B, Platko J, van der Woude M, Simons B, de Graaf F, Calvo J, et al. Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coli. Proc Natl Acad Sci U S A. 1992;89:4250-4 pubmed
    The methylation blocking factor gene (mbf) in Escherichia coli is required for specific methylation inhibition of two DNA GATC sites upstream of the papBA pilin promoter and transcriptional activation of pap...
  30. Graveline R, Mourez M, Hancock M, Martin C, Boisclair S, Harel J. Lrp-DNA complex stability determines the level of ON cells in type P fimbriae phase variation. Mol Microbiol. 2011;81:1286-99 pubmed publisher
    ..phase variation is due to altered stability of the DNA complex formed by the leucine-responsive regulatory protein (Lrp) at its repressor binding sites 1-3; after each cell cycle, complex formation is also modulated by the local ..
  31. Tuan L, D Ari R, Newman E. The leucine regulon of Escherichia coli K-12: a mutation in rblA alters expression of L-leucine-dependent metabolic operons. J Bacteriol. 1990;172:4529-35 pubmed
    ..We propose that the rbl gene product is the regulator of a global response to leucine. ..
  32. Anderson J, Quay S, Oxender D. Mapping of two loci affecting the regulation of branched-chain amino acid transport in Escherichia coli K-12. J Bacteriol. 1976;126:80-90 pubmed
    ..system (lstR) and both the leucine-specific and the general branched-chain amino acid transport LIV-I systems (livR) were mapped by conjugation and transduction...
  33. Antonucci T, Wagner L, Oxender D. Cloning, expression, and nucleotide sequence of livR, the repressor for high-affinity branched-chain amino acid transport in Escherichia coli. Proteins. 1986;1:125-33 pubmed
    The livR gene encoding the repressor for high-affinity branched-chain amino acid transport in Escherichia coli has been cloned from a library prepared from the episome F106...
  34. Langley D, Guest J. Biochemical genetics of the alpha-keto acid dehydrogenase complexes of Escherichia coli K12: genetic characterization and regulatory properties of deletion mutants. J Gen Microbiol. 1978;106:103-17 pubmed
  35. Park J, Lee K, Kim T, Lee S. Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation. Proc Natl Acad Sci U S A. 2007;104:7797-802 pubmed
    ..Among the down-regulated genes, the lrp and ygaZH genes, which encode a global regulator Lrp and L-valine exporter, respectively, were overexpressed...
  36. Kutukova E, Livshits V, Altman I, Ptitsyn L, Zyiatdinov M, Tokmakova I, et al. The yeaS (leuE) gene of Escherichia coli encodes an exporter of leucine, and the Lrp protein regulates its expression. FEBS Lett. 2005;579:4629-34 pubmed
    ..The expression of yeaS (renamed leuE for "leucine export") was induced by leucine, l-alpha-amino-n-butyric acid and, to a lesser extent, by several other amino acids. The global regulator Lrp mediated this induction.
  37. Yokoyama K, Ishijima S, Clowney L, Koike H, Aramaki H, Tanaka C, et al. Feast/famine regulatory proteins (FFRPs): Escherichia coli Lrp, AsnC and related archaeal transcription factors. FEMS Microbiol Rev. 2006;30:89-108 pubmed
  38. Cui Y, Wang Q, Stormo G, Calvo J. A consensus sequence for binding of Lrp to DNA. J Bacteriol. 1995;177:4872-80 pubmed
    b>Lrp (leucine-responsive regulatory protein) is a major regulatory protein involved in the expression of numerous operons in Escherichia coli...
  39. van der Woude M, Kaltenbach L, Low D. Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon. Mol Microbiol. 1995;17:303-12 pubmed
    ..In this study, we explore the roles of leucine-responsive regulatory protein (Lrp) and the histone-like protein H-NS in the regulation of pap phase variation...
  40. Holmqvist E, Unoson C, Reimegård J, Wagner E. A mixed double negative feedback loop between the sRNA MicF and the global regulator Lrp. Mol Microbiol. 2012;84:414-27 pubmed publisher
    Roughly 10% of all genes in Escherichia coli are controlled by the global transcription factor Lrp, which responds to nutrient availability...
  41. Berthiaume F, Crost C, Labrie V, Martin C, Newman E, Harel J. Influence of L-leucine and L-alanine on Lrp regulation of foo, coding for F1651, a Pap homologue. J Bacteriol. 2004;186:8537-41 pubmed
    ..Using an Lrp-deficient host and the lrp gene cloned under the arabinose pBAD promoter, we demonstrated that foo was transcribed ..
  42. Kuhn J, Somerville R. Mutant strains of Escherichia coli K12 that use D-amino acids. Proc Natl Acad Sci U S A. 1971;68:2484-7 pubmed
    ..They result in high activities of an enzyme that deaminates D-amino acids. Neither the enzymes of the tryptophan biosynthetic pathway nor tryptophanase (EC 4.2.1.e) are involved in D-tryptophan utilization. ..
  43. Gazeau M, Delort F, Dessen P, Blanquet S, Plateau P. Escherichia coli leucine-responsive regulatory protein (Lrp) controls lysyl-tRNA synthetase expression. FEBS Lett. 1992;300:254-8 pubmed
    ..The transposon giving rise to the altered expression of lysU was found inserted within lrp. The latter gene codes for the leucine-responsive regulatory protein (Lrp) which mediates a global response of the ..
  44. Hart B, Mishra P, Lintner R, Hinerman J, Herr A, Blumenthal R. Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus. J Bacteriol. 2011;193:3794-803 pubmed publisher
    The AsnC/Lrp family of regulatory proteins links bacterial and archaeal transcription patterns to metabolism. In Escherichia coli, Lrp regulates approximately 400 genes, over 200 of them directly...
  45. Zhi J, Mathew E, Freundlich M. Lrp binds to two regions in the dadAX promoter region of Escherichia coli to repress and activate transcription directly. Mol Microbiol. 1999;32:29-40 pubmed
    The dadAX operon is expressed by multiple promoters that are repressed by leucine-responsive regulatory protein (Lrp) and activated by cyclic AMP-CRP...
  46. Newman E, D Ari R, Lin R. The leucine-Lrp regulon in E. coli: a global response in search of a raison d'être. Cell. 1992;68:617-9 pubmed
  47. Kelly A, Conway C, O Cróinín T, Smith S, Dorman C. DNA supercoiling and the Lrp protein determine the directionality of fim switch DNA inversion in Escherichia coli K-12. J Bacteriol. 2006;188:5356-63 pubmed
    ..Instead, the leucine-responsive regulatory (Lrp) protein was found to determine switching outcomes...
  48. Cui Y, Midkiff M, Wang Q, Calvo J. The leucine-responsive regulatory protein (Lrp) from Escherichia coli. Stoichiometry and minimal requirements for binding to DNA. J Biol Chem. 1996;271:6611-7 pubmed
    b>Lrp (Leucine-responsive regulatory protein) regulates the expression of a number of operons in Escherichia coli...
  49. Kutukova E, Zakataeva N, Livshits V. [Expression of the genes encoding RhtB family proteins depends on global regulator Lrp]. Mol Biol (Mosk). 2005;39:374-8 pubmed
    ..It is shown that expression of these genes is under control of the global regulator Lrp, depends on the presence of some amino acids in growth medium, and increases during different physiological ..
  50. Ihara K, Sato K, Hori H, Makino Y, Shigenobu S, Ando T, et al. Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli. J Biosci Bioeng. 2017;123:444-450 pubmed publisher
    ..In this study, the global regulator leucine-responsive regulatory protein (Lrp) was identified as an activator of the alaE gene...
  51. Starcic Erjavec M, van Putten J, Gaastra W, Jordi B, Grabnar M, Zgur Bertok D. H-NS and Lrp serve as positive modulators of traJ expression from the Escherichia coli plasmid pRK100. Mol Genet Genomics. 2003;270:94-102 pubmed
    ..Nucleotide sequence analysis revealed potential Lrp and H-NS binding sites in the traJ regulatory region...
  52. Peeters E, Nguyen Le Minh P, Foulquié Moreno M, Charlier D. Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP. Mol Microbiol. 2009;74:1513-26 pubmed publisher
    ..transcription of the argO gene coding for an arginine exporter is regulated by the global transcriptional regulator Lrp, an effect that went by unnoticed in previous genome-scale screenings of the Lrp regulatory network in Escherichia ..
  53. Lahooti M, Roesch P, Blomfield I. Modulation of the sensitivity of FimB recombination to branched-chain amino acids and alanine in Escherichia coli K-12. J Bacteriol. 2005;187:6273-80 pubmed
    ..and is influenced by auxiliary factors integration host factor (IHF) and leucine-responsive regulatory protein (Lrp)...
  54. Corcoran C, Dorman C. DNA relaxation-dependent phase biasing of the fim genetic switch in Escherichia coli depends on the interplay of H-NS, IHF and LRP. Mol Microbiol. 2009;74:1071-82 pubmed publisher
    ..This orientational bias is known to require binding of the nucleoid-associated protein LRP within fimS...
  55. Dame R. The role of nucleoid-associated proteins in the organization and compaction of bacterial chromatin. Mol Microbiol. 2005;56:858-70 pubmed
    ..Many of these new insights can be attributed to the use of recently developed biophysical techniques. ..
  56. Ursini M, Arcari P, De Felice M. Acetohydroxy acid synthase isoenzymes of Escherichia coli K-12: a trans-acting regulatory locus of ilvHI gene expression. Mol Gen Genet. 1981;181:491-6 pubmed
    ..This mutation was found to lie outside the structural genes ilvHI for this isoenzyme and was designated lrs-1...
  57. Lintner R, Mishra P, Srivastava P, Martinez Vaz B, Khodursky A, Blumenthal R. Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio. BMC Microbiol. 2008;8:60 pubmed publisher
    ..In E. coli K-12 the leucine-responsive regulatory protein (Lrp) affects expression of approximately 400 genes...
  58. Peterson S, Reich N. Competitive Lrp and Dam assembly at the pap regulatory region: implications for mechanisms of epigenetic regulation. J Mol Biol. 2008;383:92-105 pubmed publisher
    Escherichia coli DNA adenine methyltransferase (Dam) and Leucine-responsive regulatory protein (Lrp) are key regulators of the pap operon, which codes for the pilus proteins necessary for uropathogenic E. coli cellular adhesion...
  59. Baek C, Wang S, Roland K, Curtiss R. Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium. J Bacteriol. 2009;191:1278-92 pubmed publisher
    Leucine-responsive regulatory protein (Lrp) is a global gene regulator that influences expression of a large number of genes including virulence-related genes in Escherichia coli and Salmonella...
  60. Pul U, Wurm R, Lux B, Meltzer M, Menzel A, Wagner R. LRP and H-NS--cooperative partners for transcription regulation at Escherichia coli rRNA promoters. Mol Microbiol. 2005;58:864-76 pubmed
    ..Here we provide evidence for another player, the regulatory protein LRP, which binds with high specificity to all seven Escherichia coli rRNA P1 promoter upstream regions (UAS)...
  61. Yang L, Lin R, Newman E. Structure of the Lrp-regulated serA promoter of Escherichia coli K-12. Mol Microbiol. 2002;43:323-33 pubmed
    Expression of the Escherichia coli serA gene is activated in vivo by the product of the lrp gene, leucine-responsive regulatory protein (Lrp), an effect partially reversed by L-leucine...
  62. Graveline R, Garneau P, Martin C, Mourez M, Hancock M, Lavoie R, et al. Leucine-responsive regulatory protein Lrp and PapI homologues influence phase variation of CS31A fimbriae. J Bacteriol. 2014;196:2944-53 pubmed publisher
    ..control of methylation-dependent transcriptional regulation, for which the leucine-responsive regulatory protein (Lrp) is essential...
  63. Braaten B, Blyn L, Skinner B, Low D. Evidence for a methylation-blocking factor (mbf) locus involved in pap pilus expression and phase variation in Escherichia coli. J Bacteriol. 1991;173:1789-800 pubmed
    ..We have identified a chromosomal locus, mbf (methylation-blocking factor), that is required for methylation protection of both the pap GATC1028 and GATC1130 ..