Gene Symbol: lpxP
Description: palmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase
Alias: ECK2374, JW2375, ddg
Species: Escherichia coli str. K-12 substr. MG1655
Carty S, Sreekumar K, Raetz C. Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. J Biol Chem. 1999;274:9677-85 pubmed
..coli. This lpxL homologue, designated lpxP, encodes the cold shock-induced palmitoleoyl transferase...
Vorachek Warren M, Carty S, Lin S, Cotter R, Raetz C. An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. J Biol Chem. 2002;277:14186-93 pubmed
An acyltransferase induced by cold shock in Escherichia coli, designated LpxP, incorporates a palmitoleoyl moiety into nascent lipid A in place of the secondary laurate chain normally added by LpxL(HtrB) (Carty, S. M., Sreekumar, K. R...
Vorachek Warren M, Ramirez S, Cotter R, Raetz C. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. J Biol Chem. 2002;277:14194-205 pubmed
..carrier protein-dependent late acyltransferases of lipid A biosynthesis, designated lpxL(htrB), lpxM(msbB), and lpxP, were generated in Escherichia coli K12 W3110...
Rezuchova B, Miticka H, Homerova D, Roberts M, Kormanec J. New members of the Escherichia coli sigmaE regulon identified by a two-plasmid system. FEMS Microbiol Lett. 2003;225:1-7 pubmed
..proteins involved in primary metabolism (fusA, tufA, recR), phospholipid and lipopolysaccharide biosynthesis (psd, lpxP), signal transduction (sixA), proposed inner or outer membrane proteins (bacA, sbmA, smpA, yeaY), and proteins with ..
Raetz C, Reynolds C, Trent M, Bishop R. Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem. 2007;76:295-329 pubmed
..Although not required for growth, the modification enzymes modulate virulence of some gram-negative pathogens. Heterologous expression of lipid A modification enzymes may enable the development of new vaccines. ..
Mansilla M, Cybulski L, Albanesi D, de Mendoza D. Control of membrane lipid fluidity by molecular thermosensors. J Bacteriol. 2004;186:6681-8 pubmed
Trent M. Biosynthesis, transport, and modification of lipid A. Biochem Cell Biol. 2004;82:71-86 pubmed