ldrD

Summary

Gene Symbol: ldrD
Description: toxic polypeptide, small
Alias: ECK3524, JW5966
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Kawano M, Kanaya S, Oshima T, Masuda Y, Ara T, Mori H. Distribution of repetitive sequences on the leading and lagging strands of the Escherichia coli genome: comparative study of Long Direct Repeat (LDR) sequences. DNA Res. 2002;9:1-10 pubmed
    ..Adaptation of individual LDRs to E. coli genome is also discussed on the basis of codon usage. ..
  2. Kawano M, Oshima T, Kasai H, Mori H. Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Mol Microbiol. 2002;45:333-49 pubmed
    ..In this study, we demonstrate that LDR-D encodes a 35-amino-acid peptide, LdrD, the overexpression of which causes rapid cell killing and nucleoid condensation of the host cell...
  3. Gerdes K, Wagner E. RNA antitoxins. Curr Opin Microbiol. 2007;10:117-24 pubmed
    ..Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR). ..
  4. Fozo E, Kawano M, Fontaine F, Kaya Y, Mendieta K, Jones K, et al. Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Mol Microbiol. 2008;70:1076-93 pubmed publisher
    ..Whole genome expression analysis showed that overexpression of IbsC and ShoB, as well as the small hydrophobic LdrD and TisB proteins, has both overlapping and unique consequences for the cell.