Gene Symbol: ldrA
Description: toxic polypeptide, small
Alias: ECK1204, JW5957
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Kawano M, Kanaya S, Oshima T, Masuda Y, Ara T, Mori H. Distribution of repetitive sequences on the leading and lagging strands of the Escherichia coli genome: comparative study of Long Direct Repeat (LDR) sequences. DNA Res. 2002;9:1-10 pubmed
    ..Adaptation of individual LDRs to E. coli genome is also discussed on the basis of codon usage. ..
  2. Kawano M, Oshima T, Kasai H, Mori H. Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Mol Microbiol. 2002;45:333-49 pubmed
    ..We propose that LDR encodes a toxin-antitoxin module. LDR-homologous sequences are not pre-sent on any known plasmids but are conserved in Salmonella and other enterobacterial species. ..
  3. Gerdes K, Wagner E. RNA antitoxins. Curr Opin Microbiol. 2007;10:117-24 pubmed
    ..Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR). ..
  4. Yamaguchi Y, Tokunaga N, Inouye M, Phadtare S. Characterization of LdrA (long direct repeat A) protein of Escherichia coli. J Mol Microbiol Biotechnol. 2014;24:91-7 pubmed publisher
    ..The long direct repeat (Ldr) family of proteins belongs to one such TA system. Here we report characterization of LdrA, the prototypical protein of the Ldr family, and show that it is highly toxic for cell growth...

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