Gene Symbol: kduD
Description: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; KDG oxidoreductase; 20-ketosteroid reductase
Alias: ECK2840, JW2810, ygeC, yqeD
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Hu W, Tedesco S, McDonagh B, Bárcena J, Keane C, Sheehan D. Selection of thiol- and disulfide-containing proteins of Escherichia coli on activated thiol-Sepharose. Anal Biochem. 2010;398:245-53 pubmed publisher
    ..coli. ATS provides a convenient and rapid way to select thiol-containing proteins. ..
  2. Condemine G, Robert Baudouy J. Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation. Mol Microbiol. 1991;5:2191-202 pubmed
    ..The functions of two of these genes are known: kduD codes for the 2-keto-3-deoxygluconate oxydoreductase and kdul for the 5-keto-4-deoxyuronate isomerase, two enzymes ..
  3. Rodionov D, Gelfand M, Hugouvieux Cotte Pattat N. Comparative genomics of the KdgR regulon in Erwinia chrysanthemi 3937 and other gamma-proteobacteria. Microbiology. 2004;150:3571-90 pubmed
    ..In particular, possible non-orthologous substitutes of isomerase KduI and a new oligogalacturonide transporter in the Vibrio species were detected. ..
  4. Maiden M, Jones Mortimer M, Henderson P. The cloning, DNA sequence, and overexpression of the gene araE coding for arabinose-proton symport in Escherichia coli K12. J Biol Chem. 1988;263:8003-10 pubmed
    ..Arabinose protected this protein against reaction with N-ethylmaleimide. ..
  5. Hugouvieux Cotte Pattat N, Condemine G, Nasser W, Reverchon S. Regulation of pectinolysis in Erwinia chrysanthemi. Annu Rev Microbiol. 1996;50:213-57 pubmed
    ..Other proteins involved in global regulations, such as CRP or HNS, can bind to the regulatory regions of the pectinase genes and affect their transcription. ..
  6. Tubeleviciute A, Teese M, Jose J. Escherichia coli kduD encodes an oxidoreductase that converts both sugar and steroid substrates. Appl Microbiol Biotechnol. 2014;98:5471-85 pubmed publisher
    ..coli UT5600 (DE3). Only the overexpression of 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (KduD) encoded by kduD gene enabled the whole-cell biotransformation of 11-DOC...
  7. Hannemann F, Bernhardt R, Jose J. Biocatalytic synthesis of 4-pregnen-20,21-diol-3-one, a selective inhibitor of human 5alpha-reductase type II. J Enzyme Inhib Med Chem. 2007;22:570-6 pubmed
    ..5 microM detectable. The IC50 value of 4-pregnen-20,21-diol-3-one for human 5alpha-reductase type II was determined to be 1.56 microM. ..
  8. Rothe M, Alpert C, Loh G, Blaut M. Novel insights into E. coli's hexuronate metabolism: KduI facilitates the conversion of galacturonate and glucuronate under osmotic stress conditions. PLoS ONE. 2013;8:e56906 pubmed publisher
    Using a gnotobiotic mouse model, we previously observed the upregulation of 2-deoxy-D-gluconate 3-dehydrogenase (KduD) in intestinal E...