Gene Symbol: IS26-TnpA
Description: IS26-TnpA
Alias: IS26-TnpA
Species: Escherichia coli

Top Publications

  1. Poirel L, Naas T, Guibert M, Chaibi E, Labia R, Nordmann P. Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene. Antimicrob Agents Chemother. 1999;43:573-81 pubmed
    ..Furthermore, blaVEB-1 is encoded on a large (> 100-kb) transferable plasmid found in a Klebsiella pneumoniae MG-2 isolated at the same time from the same patient, indicating a horizontal gene transfer...
  2. Sabat M, Tarrag R, Navarro F, Mir E, Verg s C, Barb J, et al. Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain. Antimicrob Agents Chemother. 2000;44:1970-3 pubmed
    ..Outside of this region there are only six amino acids substitutions between both proteins...
  3. Naas T, Mikami Y, Imai T, Poirel L, Nordmann P. Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes. J Bacteriol. 2001;183:235-49 pubmed publisher
    ..Target site duplication at both ends of the transposon indicated that the integron likely was inserted into the plasmid through a transpositional process. This is the first description of an integron located on a composite transposon...
  4. Sabat M, Navarro F, Mir E, Campoy S, Mirelis B, Barb J, et al. Novel complex sul1-type integron in Escherichia coli carrying bla(CTX-M-9). Antimicrob Agents Chemother. 2002;46:2656-61 pubmed
    ..Furthermore, a new insertion sequence, IS3000, has been found in In60. PCR analysis indicates that integron In60 is present in 33 of 34 nonclonal enterobacterial isolates carrying the putative beta-lactamase CTX-M-9...
  5. Doroshenko V, Livshits V. Structure and mode of transposition of Tn2555 carrying sucrose utilization genes. FEMS Microbiol Lett. 2004;233:353-9 pubmed
    ..3 translocation from pBR325 to RP4 occurs via a cointegrate formation, mediated by one of the three IS26 copies, followed by its resolution due to RecA-dependent recombination between two direct IS26 copies flanking the donor replicon. ..
  6. Papagiannitsis C, Loli A, Tzouvelekis L, Tzelepi E, Arlet G, Miriagou V. SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. Antimicrob Agents Chemother. 2007;51:2185-8 pubmed
    ..The interaction of SCO-1 with beta-lactams was similar to that of the CARB-type enzymes. Also, SCO-1 exhibited a 51% amino acid sequence identity with the RTG subgroup of chromosomal carbenicillinases (RTG-1, CARB-5, and CARB-8). ..
  7. Papagiannitsis C, Tzouvelekis L, Tzelepi E, Miriagou V. Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrob Agents Chemother. 2007;51:3763-7 pubmed
    ..Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins. ..
  8. Doroshenko V, Danilevich V, Karataev G, Livshits V. [Structural and functional organization of the transposon Tn2555 carrying saccharose utilization genes]. Mol Biol (Mosk). 1988;22:645-58 pubmed
    ..It was found that the Tn2555 family elements are flanked by directly repeated IS286. One of them (Tn2555.3) contains an additional copy of IS286 in its internal region. ..
  9. Wrighton C, Strike P. A pathway for the evolution of the plasmid NTP16 involving the novel kanamycin resistance transposon Tn4352. Plasmid. 1987;17:37-45 pubmed
    ..The sequence analysis suggests that the initial insertion was into the tnpR gene of the ampicillin transposon, followed by a deletion extending to a specific site within tnpA. ..

More Information


  1. Perreten V, Boerlin P. A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland. Antimicrob Agents Chemother. 2003;47:1169-72 pubmed
    ..coli. Two copies of the insertion element IS15Delta/26 flanked the region containing sul3. The sul3 gene was detected in one-third of the sulfonamide-resistant pathogenic E. coli isolates from pigs in Switzerland...
  2. Vourli S, Tzouvelekis L, Tzelepi E, Lebessi E, Legakis N, Miriagou V. Characterization of In111, a class 1 integron that carries the extended-spectrum beta-lactamase gene blaIBC-1. FEMS Microbiol Lett. 2003;225:149-53 pubmed
    ..The 3'CS included sulI, qacEDelta1, orf5 and orf6. In111 was bounded on the right by an inversely oriented IRt. The 5'CS was preceded by an intact IS26 element followed by an aphA1 gene...
  3. Yamane K, Wachino J, Suzuki S, Kimura K, Shibata N, Kato H, et al. New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2007;51:3354-60 pubmed publisher
    ..coli was first identified. Surveillance of the qepA-harboring clinical isolates should be encouraged to minimize further dissemination of the kind of plasmid-dependent FQ resistance determinants among pathogenic microbes...
  4. McGann P, Snesrud E, Ong A, Appalla L, Koren M, Kwak Y, et al. War wound treatment complications due to transfer of an IncN plasmid harboring bla(OXA-181) from Morganella morganii to CTX-M-27-producing sequence type 131 Escherichia coli. Antimicrob Agents Chemother. 2015;59:3556-62 pubmed publisher
    ..We highlight the importance of surveillance for carbapenem resistance in all species, even those with intrinsic resistances, and the value of advanced molecular techniques in detecting subtle genetic changes. ..
  5. Miriagou V, Tzouvelekis L, Villa L, Lebessi E, Vatopoulos A, Carattoli A, et al. CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid. Antimicrob Agents Chemother. 2004;48:3172-4 pubmed publisher
    ..ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments...