Gene Symbol: ilvY
Description: transcriptional activator of ilvC; autorepressor
Alias: ECK3765, JW3746
Species: Escherichia coli str. K-12 substr. MG1655
Wek R, Hatfield G. Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli. J Mol Biol. 1988;203:643-63 pubmed
..This substrate induction is mediated by a positive activator encoded by an adjacent gene, ilvY. The ilvY and ilvC genes are transcribed in opposite directions from promoters that are overlapping...
Aldea M, Maples V, Kushner S. Generation of a detailed physical and genetic map of the ilv-metE-udp region of the Escherichia coli chromosome. J Mol Biol. 1988;200:427-38 pubmed
Wek R, Hatfield G. Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters. J Biol Chem. 1986;261:2441-50 pubmed
..and that this substrate induction of ilvC expression is mediated by a positive activator encoded by the ilvY gene. We report here the isolation and complete nucleotide sequence of the ilvY and ilvC genes...
Opel M, Arfin S, Hatfield G. The effects of DNA supercoiling on the expression of operons of the ilv regulon of Escherichia coli suggest a physiological rationale for divergently transcribed operons. Mol Microbiol. 2001;39:1109-15 pubmed
..As DNA supercoiling-dependent transcriptional coupling between the promoters of other divergently transcribed operons is investigated, additional global gene regulatory mechanisms and physiological roles are sure to emerge. ..
Henikoff S, Haughn G, Calvo J, Wallace J. A large family of bacterial activator proteins. Proc Natl Acad Sci U S A. 1988;85:6602-6 pubmed
..The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB; Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other ..
Sameshima J, Wek R, Hatfield G. Overlapping transcription and termination of the convergent ilvA and ilvY genes of Escherichia coli. J Biol Chem. 1989;264:1224-31 pubmed
The ilvY gene of Escherichia coli is transcribed in a direction opposite to the ilvGMEDA operon, and the translational stop codons of the ilvA and ilvY genes are only 52 base pairs (bp) apart...
Lawther R, Wek R, Lopes J, Pereira R, Taillon B, Hatfield G. The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Res. 1987;15:2137-55 pubmed
..This new information contributes to a more complete understanding of the overall control of the biosynthesis of isoleucine and valine...
Warne S, Varley J, Boulnois G, Norton M. Identification and characterization of a gene that controls colony morphology and auto-aggregation in Escherichia coli K12. J Gen Microbiol. 1990;136:455-62 pubmed
..The putative protein sequence shows a high level of homology with four regulatory genes, the ilvY, cysB and lysR genes from E. coli and the metR gene from Salmonella typhimurium...
Rhee K, Senear D, Hatfield G. Activation of gene expression by a ligand-induced conformational change of a protein-DNA complex. J Biol Chem. 1998;273:11257-66 pubmed
b>IlvY protein binds cooperatively to tandem operator sites in the divergent, overlapping, promoter-regulatory region of the ilvYC operon of Escherichia coli...