Gene Symbol: hscC
Description: Hsp70 family chaperone Hsc62; RpoD-binding transcription inhibitor
Alias: ECK0643, JW0645, ybeW
Species: Escherichia coli str. K-12 substr. MG1655
Yoshimune K, Yoshimura T, Esaki N. Hsc62, a new DnaK homologue of Escherichia coli. Biochem Biophys Res Commun. 1998;250:115-8 pubmed
..Hsc66 is activated by DnaJ of E. coli in the same manner as DnaK, the natural partner protein of DnaJ. However, Hsc62 is distinct from the others: the ATPase activity of Hsc62 was not elevated by DnaJ. ..
Itoh T, Matsuda H, Mori H. Phylogenetic analysis of the third hsp70 homolog in Escherichia coli; a novel member of the Hsc66 subfamily and its possible co-chaperone. DNA Res. 1999;6:299-305 pubmed
..coli possesses at least three Hsp70 homologs (DnaK, Hsc66 and Hsc62). We found that Hsc62, which is the product of hscC, is a new member of the Hsc66 subfamily, and is specific to E. coli. The analysis also suggested that YegD of E...
Yoshimune K, Yoshimura T, Nakayama T, Nishino T, Esaki N. Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli. Biochem Biophys Res Commun. 2002;293:1389-95 pubmed
..Hsc62 is structurally and biochemically similar to DnaK, but hscC gene encoding Hsc62 did not compensate for the defects in the dnaK-null mutant of E. coli MC4100 strain...
Arifuzzaman M, Oshima T, Nakade S, Mori H. Characterization of HscC (Hsc62), homologue of Hsp70 in Escherichia coli: over-expression of HscC modulates the activity of house keeping sigma factor sigma70. Genes Cells. 2002;7:553-66 pubmed
b>HscC, the third member of the Hsp70 family in Escherichia coli, shares 33% identity with the other two homologues, DnaK and HscA, and displays ATPase activity...
Arifuzzaman M, Oshima T, Mori H. The ATPase domain of HscC (DnaK homolog) is essential for interfering sigma70 activity in E. coli. FEMS Microbiol Lett. 2004;230:99-104 pubmed
b>HscC, a DnaK homolog in Escherichia coli, consists of adenosine triphosphatase (ATPase), substrate-binding and C-terminal domains...
Hennessy F, Nicoll W, Zimmermann R, Cheetham M, Blatch G. Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Protein Sci. 2005;14:1697-709 pubmed
..We also propose a model in which the J domain is able to integrate specificity and chaperone activity. ..
Genevaux P, Georgopoulos C, Kelley W. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Mol Microbiol. 2007;66:840-57 pubmed
..In particular, recent advances in structure determination have led to significant insights of the underlying complexities and functional elegance of the Hsp70 chaperone machine. ..
Kluck C, Patzelt H, Genevaux P, Brehmer D, Rist W, Schneider Mergener J, et al
. Structure-function analysis of HscC, the Escherichia coli member of a novel subfamily of specialized Hsp70 chaperones. J Biol Chem. 2002;277:41060-9 pubmed
..within the Hsp70 family of proteins, we characterized the Escherichia coli member of a novel Hsp70 subfamily, HscC, and identified considerable differences to the well studied E...