Gene Symbol: hpt
Description: hypoxanthine phosphoribosyltransferase
Alias: ECK0124, JW5009
Species: Escherichia coli str. K-12 substr. MG1655
Hochstadt J. Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria. Methods Enzymol. 1978;51:549-58 pubmed
Page M, Burton K. The location of purine phosphoribosyltransferase activities in Escherichia coli. Biochem J. 1978;174:717-25 pubmed
Jochimsen B, Nygaard P, Vestergaard T. Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt). Mol Gen Genet. 1975;143:85-91 pubmed
..The gene gsk encoding guanosine kinase was cotransducible with purE and shown to be located at 13 min. The gene hpt encoding hypoxanthine phosphoribosyltransferase was cotransducible with tonA indicating a location at 3 min...
Holden J, Harriman P, Wall J. Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase. J Bacteriol. 1976;126:1141-8 pubmed
..Thus, the gpt gene is only one of at least two genes responsible for guanine PRTase activity in E. coli. ..
Brikun I, Sukhodolets V. [Characteristics of the phenotypic manifestation of hpt and gpt mutations blocking 6-oxypurine utilization and their effect on the expression of catabolite-sensitive genes in the cells of an Escherichia coli K-12 purine auxotroph]. Genetika. 1985;21:902-13 pubmed
..of utilization of hypoxanthine, guanine and xanthine by means of phosphoribosyltransferases, as a result of the hpt and gpt mutations, have the Rel phenotype...
Bruce I, Hardy J, Stacey K. Potentiation by purines of the growth-inhibitory effects of sulphonamides on Escherichia coli K12 and the location of the gene which mediates this effect. J Gen Microbiol. 1984;130:2489-95 pubmed
..This result suggests that these lysogens are heterozygous for psp and that the wild-type allele is dominant. It is probable that psp is a regulatory gene, affecting some rate-limiting step in the biosynthesis of methionine. ..
Levine R, Taylor M. Selection for purine regulatory mutants in an E. coli hypoxanthine phosphoribosyl transferase-guanine phosphoribosyl transferase double mutant. Mol Gen Genet. 1981;181:313-8 pubmed
..led to the isolation of a hypoxanthine phosphoribosyl transferase-guanine phosphoribosyl transferase double mutant (hpt- gpt-) that is extremely sensitive to adenine...
Brikun I, Sukhodolets V. [Phenotypic properties of Escherichia coli K-12 purine auxotrophs with disordered synthesis of guanine, xanthine and hypoxanthine phosphoribosyltransferases]. Genetika. 1981;17:932-5 pubmed
..blocked for reutilization of guanine, xanthine and hypoxanthine via phosphoribosiltransferase reactions (purD hpt gpt) were studied...
Brikun I, Livshits V, Strauss M. [Genetic study of the mutations impairing guanine, xanthine and hypoxanthines assimilation in a purine auxotroph of Escherichia coli K-12]. Genetika. 1981;17:258-67 pubmed
The hpt gene is responsible for the synthesis of hypoxanthine-guanine phosphoribosiltransferase...