hpf

Summary

Gene Symbol: hpf
Description: ribosome hibernation promoting factor HPF; stabilizes 100S dimers
Alias: ECK3192, JW3170, yhbH
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Jones D, Franklin F, Thomas C. Molecular analysis of the operon which encodes the RNA polymerase sigma factor sigma 54 of Escherichia coli. Microbiology. 1994;140 ( Pt 5):1035-43 pubmed publisher
    ..The homologies therefore suggest that this effect on sigma 54 may be mediated by sequential protein phosphorylation and suggest that there is a link between signal transduction and transcription of sigma 54-dependent genes...
  2. Maki Y, Yoshida H, Wada A. Two proteins, YfiA and YhbH, associated with resting ribosomes in stationary phase Escherichia coli. Genes Cells. 2000;5:965-74 pubmed
    ..coli ribosomes in the stationary phase. These proteins are the products of ORFs named yfiA and yhbH. The sum of the copy numbers of their product proteins, YfiA and YhbH, in the ribosomal particles was low in the ..
  3. Bubunenko M, Baker T, Court D. Essentiality of ribosomal and transcription antitermination proteins analyzed by systematic gene replacement in Escherichia coli. J Bacteriol. 2007;189:2844-53 pubmed
    ..proteins are essential, while all four of the minor ribosome-associated proteins examined (RMF, SRA, YfiA, and YhbH), unlike most ribosomal proteins, are dispensable...
  4. Ueta M, Ohniwa R, Yoshida H, Maki Y, Wada C, Wada A. Role of HPF (hibernation promoting factor) in translational activity in Escherichia coli. J Biochem. 2008;143:425-33 pubmed publisher
    ..stationary phase of growth in Escherichia coli, ribosome modulation factor (RMF) and hibernation promoting factor (HPF) dimerize most 70S ribosomes to form 100S ribosomes...
  5. Powell B, Court D, Inada T, Nakamura Y, Michotey V, Cui X, et al. Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant. J Biol Chem. 1995;270:4822-39 pubmed
    ..These results support our previous proposal of a novel mechanism linking carbon and nitrogen assimilation and relates IIANtr to the unknown process regulated by the essential GTPase Era...
  6. Imaishi H, Gomada M, Inouye S, Nakazawa A. Physical map location of the rpoN gene of Escherichia coli. J Bacteriol. 1993;175:1550-1 pubmed
  7. El Sharoud W. Ribosome inactivation for preservation: concepts and reservations. Sci Prog. 2004;87:137-52 pubmed
    ..Such proteins include ribosome modulation factor (RMF), YfiA and YhbH. Examining the influence of RMF on the survival of E...
  8. Ueta M, Yoshida H, Wada C, Baba T, Mori H, Wada A. Ribosome binding proteins YhbH and YfiA have opposite functions during 100S formation in the stationary phase of Escherichia coli. Genes Cells. 2005;10:1103-12 pubmed publisher
    During the stationary phase of Escherichia coli growth, ribosomal structure changes drastically. Proteins RMF, YhbH, YfiA and SRA are expressed and bind to ribosome particles...
  9. Yoshida H, Ueta M, Maki Y, Sakai A, Wada A. Activities of Escherichia coli ribosomes in IF3 and RMF change to prepare 100S ribosome formation on entering the stationary growth phase. Genes Cells. 2009;14:271-80 pubmed publisher
    ..dimerized (100S ribosome formation) by binding ribosome modulation factor (RMF) and hibernation promoting factor (HPF), leading to a hibernation stage...

More Information

Publications11

  1. Sato A, Watanabe T, Maki Y, Ueta M, Yoshida H, Ito Y, et al. Solution structure of the E. coli ribosome hibernation promoting factor HPF: Implications for the relationship between structure and function. Biochem Biophys Res Commun. 2009;389:580-5 pubmed publisher
    ..The hibernation promoting factor HPF plays a crucial role in 100S ribosome formation...
  2. Polikanov Y, Blaha G, Steitz T. How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science. 2012;336:915-8 pubmed publisher
    ..coli, 100S dimer formation is mediated by ribosome modulation factor (RMF) and hibernation promoting factor (HPF), or alternatively, the YfiA protein inactivates ribosomes as 70S monomers...