Genomes and Genes
Gene Symbol: hflX
Description: GTPase, stimulated by 50S subunit binding; Mn(2+) homeostasis regulator
Alias: ECK4169, JW4131, hflA, hslX
Species: Escherichia coli str. K-12 substr. MG1655
- Brown E. Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. Biochem Cell Biol. 2005;83:738-46 pubmed..of a group of 8 conserved, poorly characterized genes encoding P-loop GTPases, era, obg, trmE, yjeQ, engA, yihA, hflX, ychF, and a related ATPase, yjeE, are reviewed in considerable detail...
- Kitagawa R, Mitsuki H, Okazaki T, Ogawa T. A novel DnaA protein-binding site at 94.7 min on the Escherichia coli chromosome. Mol Microbiol. 1996;19:1137-47 pubmed..A role for the DnaA-binding site in controlling DnaA-protein concentration in the cell cycle is discussed. ..
- Tsui H, Winkler M. Transcriptional patterns of the mutL-miaA superoperon of Escherichia coli K-12 suggest a model for posttranscriptional regulation. Biochimie. 1994;76:1168-77 pubmedThe complex amiB-mutL-miaA-hfq-hflX-hflK-hflC superoperon of E coli contains important genes for several fundamental cellular processes, including cell-wall hydrolysis (amiB), DNA repair (mutL), tRNA modification (miaA) and proteolysis (..
- Gautsch J, Wulff D. Fine structure mapping, complementation, and physiology of Escherichia coli hfl mutants. Genetics. 1974;77:435-48 pubmed..It is further argued that the function of the lambdacIII gene product is to negate the antagonistic effect of this hfl(+) protein. ..
- Tsui H, Feng G, Winkler M. Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma32-specific promoters during heat shock. J Bacteriol. 1996;178:5719-31 pubmedThe amiB-mutL-miaA-hfq-hflX-hflK-hflC superoperon of Escherichia coli contains genes that are important for diverse cellular functions, including DNA mismatch repair (mutL), tRNA modification (miaA), pleiotropic regulation (hfq), and ..
- Chuang S, Blattner F. Characterization of twenty-six new heat shock genes of Escherichia coli. J Bacteriol. 1993;175:5242-52 pubmed..Possible assignments of some of the hsl genes to known proteins are discussed. ..
- Noble J, Innis M, Koonin E, Rudd K, Banuett F, Herskowitz I. The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain. Proc Natl Acad Sci U S A. 1993;90:10866-70 pubmedThe hflA (high frequency of lysogenization) locus of Escherichia coli governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein...
- Tsui H, Leung H, Winkler M. Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12. Mol Microbiol. 1994;13:35-49 pubmed..different from the parent, although transcript mapping demonstrated that the insertion was completely polar on hflX expression...
- Shields M, Fischer J, Wieden H. Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. Biochemistry. 2009;48:10793-802 pubmed publisher..The universally conserved GTPase HflX has previously been shown to associate with the 50S ribosomal subunit, as well as to bind and hydrolyze both GTP ..
- Hoyt M, Knight D, Das A, Miller H, Echols H. Control of phage lambda development by stability and synthesis of cII protein: role of the viral cIII and host hflA, himA and himD genes. Cell. 1982;31:565-73 pubmed..We have found that the stability of cII is controlled by the host hflA and viral cIII genes; hflA protein facilitates degradation of cII, whereas cIII protects cII...