Gene Symbol: hemL
Description: glutamate-1-semialdehyde aminotransferase (aminomutase)
Alias: ECK0153, JW0150, gsa?, popC
Species: Escherichia coli str. K-12 substr. MG1655
Miyashiro T, Goulian M. Stimulus-dependent differential regulation in the Escherichia coli PhoQ PhoP system. Proc Natl Acad Sci U S A. 2007;104:16305-10 pubmed
Ilag L, Jahn D. Activity and spectroscopic properties of the Escherichia coli glutamate 1-semialdehyde aminotransferase and the putative active site mutant K265R. Biochemistry. 1992;31:7143-51 pubmed
..The reaction of the PLP and PMP form of the enzyme with GSA allowed the detection of a series of peaks which varied in their intensities in a time-dependent manner...
Nishimura K, Nakayashiki T, Inokuchi H. Cloning and sequencing of the hemE gene encoding uroporphyrinogen III decarboxylase (UPD) from Escherichia coli K-12. Gene. 1993;133:109-13 pubmed
..This hemE was located at 90.3 min near the hupA gene on the linkage map of the E. coli chromosome. ..
Lüer C, Schauer S, Möbius K, Schulze J, Schubert W, Heinz D, et al
. Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis. J Biol Chem. 2005;280:18568-72 pubmed
..In accordance with this proposal, side product formation catalyzed by GluTR was observed via high performance liquid chromatography analysis in the absence of the GluTR.GSA-AM complex. ..
Grimm B, Bull A, Breu V. Structural genes of glutamate 1-semialdehyde aminotransferase for porphyrin synthesis in a cyanobacterium and Escherichia coli. Mol Gen Genet. 1991;225:1-10 pubmed
..The popC gene of E...
Minagawa S, Ogasawara H, Kato A, Yamamoto K, Eguchi Y, Oshima T, et al
. Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli. J Bacteriol. 2003;185:3696-702 pubmed
..Furthermore, S1 nuclease assays of 26 promoters were performed to verify six new Mg(2+) stimulon genes, hemL, nagA, rstAB, slyB, vboR, and yrbL, in addition to the phoPQ, mgrB, and mgtA genes reported previously...
Eguchi Y, Okada T, Minagawa S, Oshima T, Mori H, Yamamoto K, et al
. Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli. J Bacteriol. 2004;186:3006-14 pubmed
..two-component system of Escherichia coli resulted in enhanced expression of 13 PhoP/PhoQ-regulated genes, crcA, hemL, mgtA, ompT, phoP, phoQ, proP, rstA, rstB, slyB, ybjG, yrbL, and mgrB...
Ilag L, Jahn D, Eggertsson G, Soll D. The Escherichia coli hemL gene encodes glutamate 1-semialdehyde aminotransferase. J Bacteriol. 1991;173:3408-13 pubmed
..resulting phenotypes suggest that hemL may be identical with the earlier described porphyrin biosynthesis mutation popC. Complementation of the auxotrophic phenotype by wild-type DNA from the corresponding clone pLC4-43 of the Clarke-..