Gene Symbol: gspL
Description: general secretory pathway component, cryptic
Alias: ECK3320, JW5705, yheK
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Pugsley A, Francetic O. Protein secretion in Escherichia coli K-12: dead or alive?. Cell Mol Life Sci. 1998;54:347-52 pubmed
  2. Pugsley A. The complete general secretory pathway in gram-negative bacteria. Microbiol Rev. 1993;57:50-108 pubmed
    ..This recently discovered branch pathway comprises at least 14 gene products. Other, simpler terminal branches of the GSP are also used by gram-negative bacteria to secrete a more limited range of extracellular proteins. ..
  3. Fan G, Han Y, Zhang Y, Han X, Wang S, Bai H, et al. [Construction and characterization of a gspL mutant of avian pathogenic Escherichia coli]. Wei Sheng Wu Xue Bao. 2015;55:89-95 pubmed
    To study the role of gspL gene in avian pathogenic Escherichia coli. The gspL mutant of Avian pathogenic Escherichia coli (APEC) was constructed by homologous recombination assay...
  4. Francetic O, Pugsley A. The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins. J Bacteriol. 1996;178:3544-9 pubmed
    ..Thus, the gsp operon of E. coli K-12 includes at least two functional genes which, together with the rest of the operon, are probably not expressed under laboratory conditions. ..
  5. Francetic O, Belin D, Badaut C, Pugsley A. Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion. EMBO J. 2000;19:6697-703 pubmed
    ..This is the first time that secretion of an endogenous extracellular protein has been demonstrated in E.coli K-12. ..
  6. Filloux A. The underlying mechanisms of type II protein secretion. Biochim Biophys Acta. 2004;1694:163-79 pubmed
  7. Vignon G, Köhler R, Larquet E, Giroux S, Prevost M, Roux P, et al. Type IV-like pili formed by the type II secreton: specificity, composition, bundling, polar localization, and surface presentation of peptides. J Bacteriol. 2003;185:3416-28 pubmed
    ..Abnormally long pili that extend beyond the outer membrane are produced only when pilus length control and retraction are deregulated by overproduction of the major pseudopilus subunit (PulG). ..
  8. Py B, Loiseau L, Barras F. An inner membrane platform in the type II secretion machinery of Gram-negative bacteria. EMBO Rep. 2001;2:244-8 pubmed
    ..We report that in Erwinia chrysanthemi, GspE (the putative NTPase), GspF, GspL and GspM constitute a complex in the inner membrane that is presumably used as a platform for assembling other ..
  9. Sandkvist M. Biology of type II secretion. Mol Microbiol. 2001;40:271-83 pubmed
    ..Different models for pilus-mediated secretion through the gated pore in the outer membrane are also presented, as are the possible properties that determine whether a protein is recognized and secreted by the type II pathway. ..

More Information


  1. Voulhoux R, Ball G, Ize B, Vasil M, Lazdunski A, Wu L, et al. Involvement of the twin-arginine translocation system in protein secretion via the type II pathway. EMBO J. 2001;20:6735-41 pubmed
    ..Moreover, since P.aeruginosa phospholipases are secreted virulence factors, the Tat system appears to be a novel determinant of bacterial virulence. ..