Gene Symbol: ghxQ
Description: guanine/hypoxanthine permease, high affinity; guanine/hypoxanthine:H+ symporter
Alias: ECK2880, JW5467, ygfQ, ygfR
Species: Escherichia coli str. K-12 substr. MG1655
Products:     ghxQ

Top Publications

  1. Tucker D, Tucker N, Conway T. Gene expression profiling of the pH response in Escherichia coli. J Bacteriol. 2002;184:6551-8 pubmed
    ..Thus, the acid-inducible genes clustered in the gadA region appear to be involved in glutatmate-dependent acid resistance, although their specific roles remain to be elucidated...
  2. Burton K. Transport of nucleic acid bases into Escherichia coli. J Gen Microbiol. 1983;129:3505-13 pubmed
    ..This mutation has been found to lie in the neighbourhood of mtl. Competition experiments indicate that at least two other systems are used to transport guanine, xanthine and hypoxanthine. ..
  3. Xi H, Schneider B, Reitzer L. Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage. J Bacteriol. 2000;182:5332-41 pubmed
    ..Adenine sensitivity has been previously associated with defective purine salvage resulting from impaired synthesis of guanine nucleotides from adenine. We propose that xanthine dehydrogenase contributes to this purine interconversion. ..
  4. Thompson K, Rhodius V, Gottesman S. SigmaE regulates and is regulated by a small RNA in Escherichia coli. J Bacteriol. 2007;189:4243-56 pubmed
    ..Based on the plasmid screens, NsrR, a repressor sensitive to nitric oxide, was also found to negatively regulate sigma(E)-dependent promoters in an RseA-independent fashion. ..
  5. Papakostas K, Botou M, Frillingos S. Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12. J Biol Chem. 2013;288:36827-40 pubmed publisher
    ..they encode high affinity permeases for the uptake of adenine (PurP and YicO) or guanine and hypoxanthine (YjcD and YgfQ). The two pairs of paralogs differ clearly in their substrate and ligand preferences...
  6. Sabina J, Dover N, Templeton L, Smulski D, Soll D, LaRossa R. Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12. J Bacteriol. 2003;185:6158-70 pubmed
    ..Exposure of a relA strain to mupirocin resulted in accumulation of ribosomal protein operon transcripts. However, the relA strain's response to the other inhibitors was quite similar to that of the wild-type strain. ..