Gene Symbol: fucP
Description: L-fucose transporter
Alias: ECK2796, JW2772
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Kornberg H, Lourenco C. A route for fructose utilization by Escherichia coli involving the fucose regulon. Proc Natl Acad Sci U S A. 2006;103:19496-9 pubmed
    ..Here, we describe a mutant that is devoid of those proteins but takes up fructose via the FucP carrier normally used for the transport of alpha-L-fucose; this implies that the fructose is taken up in the alpha- ..
  2. Elsinghorst E, Mortlock R. Molecular cloning of the Escherichia coli B L-fucose-D-arabinose gene cluster. J Bacteriol. 1994;176:7223-32 pubmed
    ..coli strains. However, the E. coli B gene cluster contained a 5.2-kb segment located between the fucA and fucP genes that was not present in E. coli K-12...
  3. Lu Z, Lin E. The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation. Nucleic Acids Res. 1989;17:4883-4 pubmed
  4. Patrick W, Quandt E, Swartzlander D, Matsumura I. Multicopy suppression underpins metabolic evolvability. Mol Biol Evol. 2007;24:2716-22 pubmed
    ..This genome-wide survey demonstrates that multifunctional genes are common and illustrates the mechanistic diversity by which their products enhance metabolic robustness and evolvability. ..
  5. Gunn F, Tate C, Henderson P. Identification of a novel sugar-H+ symport protein, FucP, for transport of L-fucose into Escherichia coli. Mol Microbiol. 1994;12:799-809 pubmed
    ..In order to determine the nature of a putative transporter encoded by the E. coli fucP gene and identify its protein product it was cloned downstream of the inducible T7 RNA polymerase and lambda OLPL ..
  6. Skjold A, Ezekiel D. Analysis of lambda insertions in the fucose utilization region of Escherichia coli K-12: use of lambda fuc and lambda argA transducing bacteriophages to partially order the fucose utilization genes. J Bacteriol. 1982;152:120-5 pubmed
    ..Upon consideration of the transductional nature of these phage classes, we are proposing that the gene order for the L-fucose utilization system is dar, fucA, (lambda), fucC. ..
  7. Zhu Y, Lin E. An evolvant of Escherichia coli that employs the L-fucose pathway also for growth on L-galactose and D-arabinose. J Mol Evol. 1986;23:259-66 pubmed
    ..In contrast, the first variant of a negatively controlled system to emerge has an overwhelming chance of being the result of a random mutation that destroys repressor function.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  8. Bartkus J, Mortlock R. Isolation of a mutation resulting in constitutive synthesis of L-fucose catabolic enzymes. J Bacteriol. 1986;165:710-4 pubmed
    ..J. Bacteriol. 159:725-729, 1984) in that it is tightly linked to the fucose genes and appears to be located in the gene believed to code for the positive activator of the L-fucose genes. ..
  9. Podolny V, Lin E, Hochschild A. A cyclic AMP receptor protein mutant that constitutively activates an Escherichia coli promoter disrupted by an IS5 insertion. J Bacteriol. 1999;181:7457-63 pubmed
    ..For the IS5-disrupted promoter, which retains a single CRP-binding site, the additional activating region of the mutant CRP evidently compensates for the lack of upstream regulatory sequences. ..

More Information


  1. Chen Y, Zhu Y, Lin E. The organization of the fuc regulon specifying L-fucose dissimilation in Escherichia coli K12 as determined by gene cloning. Mol Gen Genet. 1987;210:331-7 pubmed
    ..2 min and constitute a regulon. These genes include fucP (encoding L-fucose permease), fucI (encoding L-fucose isomerase), fucK (encoding L-fuculose kinase), fucA (encoding ..
  2. Zhu Y, Lin E. A mutant crp allele that differentially activates the operons of the fuc regulon in Escherichia coli. J Bacteriol. 1988;170:2352-8 pubmed
    L-Fucose is used by Escherichia coli through an inducible pathway mediated by a fucP-encoded permease, a fucI-encoded isomerase, a fucK-encoded kinase, and a fucA-encoded aldolase...
  3. Spooner P, O Reilly W, Homans S, Rutherford N, Henderson P, Watts A. Weak substrate binding to transport proteins studied by NMR. Biophys J. 1998;75:2794-800 pubmed
    ..binding of sugar substrates fails to induce any quantifiable physical changes in the L-fucose-H+ symport protein, FucP, from Escherichia coli, and this protein lacks any strongly binding ligands for competitive binding assays...
  4. Saidijam M, Bettaney K, Szakonyi G, Psakis G, Shibayama K, Suzuki S, et al. Active membrane transport and receptor proteins from bacteria. Biochem Soc Trans. 2005;33:867-72 pubmed
  5. Bradley S, Tinsley C, Muiry J, Henderson P. Proton-linked L-fucose transport in Escherichia coli. Biochem J. 1987;248:495-500 pubmed
    ..5. Neither steady state kinetic measurements nor assays of L-fucose binding to periplasmic proteins revealed the existence of a second L-fucose transport system. ..
  6. Chen Y, Lu Z, Lin E. Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol. J Bacteriol. 1989;171:6097-105 pubmed
    ..The DNA of the fucAO operon and a part of the adjacent fucP was sequenced.
  7. Sugihara J, Sun L, Yan N, Kaback H. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A. 2012;109:14847-51 pubmed publisher
    b>FucP of Escherichia coli catalyzes L-fucose/H(+) symport, and a crystal structure in an outward-facing conformation has been reported. However, nothing is known about FucP conformational dynamics...
  8. Bazzone A, Madej M, Kaback H, Fendler K. pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases. PLoS ONE. 2016;11:e0156392 pubmed publisher
    ..We present here a comparative electrophysiological study of the lactose permease (LacY), the fucose permease (FucP) and the xylose permease (XylE), which reveals common mechanistic principles and differences...
  9. Gunn F, Tate C, Sansom C, Henderson P. Topological analyses of the L-fucose-H+ symport protein, FucP, from Escherichia coli. Mol Microbiol. 1995;15:771-83 pubmed
    The transport of L-fucose into Escherichia coli is mediated by the L-fucose-H+ symport protein (FucP)...
  10. Chakrabarti T, Chen Y, Lin E. Clustering of genes for L-fucose dissimilation by Escherichia coli. J Bacteriol. 1984;157:984-6 pubmed
    ..Results from this and previous studies show that all of the structural genes of the L-fucose trunk pathway map between eno and argA at minute 60.2 of the chromosome. ..