ftsK

Summary

Gene Symbol: ftsK
Description: DNA translocase at septal ring sorting daughter chromsomes
Alias: ECK0881, JW0873, dinH
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Kennedy S, Chevalier F, Barre F. Delayed activation of Xer recombination at dif by FtsK during septum assembly in Escherichia coli. Mol Microbiol. 2008;68:1018-28 pubmed publisher
    ..In Escherichia coli, the septal protein FtsK links cell division and chromosome segregation through its integral membrane N-terminal and cytoplasmic C-terminal ..
  2. Lesterlin C, Pages C, Dubarry N, Dasgupta S, Cornet F. Asymmetry of chromosome Replichores renders the DNA translocase activity of FtsK essential for cell division and cell shape maintenance in Escherichia coli. PLoS Genet. 2008;4:e1000288 pubmed publisher
    ..Strikingly, DNA translocation by FtsK, which processes the terminal junction of the replichores during cell division, becomes essential in inversion-..
  3. Sivanathan V, Allen M, de Bekker C, Baker R, Arciszewska L, Freund S, et al. The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS. Nat Struct Mol Biol. 2006;13:965-72 pubmed publisher
    The bacterial septum-located DNA translocase FtsK coordinates circular chromosome segregation with cell division...
  4. Diez A, Farewell A, Nannmark U, Nystrom T. A mutation in the ftsK gene of Escherichia coli affects cell-cell separation, stationary-phase survival, stress adaptation, and expression of the gene encoding the stress protein UspA. J Bacteriol. 1997;179:5878-83 pubmed
    An insertional mutation in ftsK, encoding an Escherichia coli product similar to the sporulation protein SpoIIIE of Bacillus subtilis, results in uspA overexpression in stationary phase and impairs cell division...
  5. Draper G, McLennan N, Begg K, Masters M, Donachie W. Only the N-terminal domain of FtsK functions in cell division. J Bacteriol. 1998;180:4621-7 pubmed
    Deletion of ftsK results in the inhibition of cell division, but this inhibition can be reversed by a plasmid carrying only the first approximately 17% of ftsK...
  6. Pérals K, Cornet F, Merlet Y, Delon I, Louarn J. Functional polarization of the Escherichia coli chromosome terminus: the dif site acts in chromosome dimer resolution only when located between long stretches of opposite polarity. Mol Microbiol. 2000;36:33-43 pubmed
    ..Dimers are lethal unless resolved by a system that involves the XerC, XerD and FtsK proteins acting at a site (dif) in the terminus region. Resolution fails if dif is moved from its normal position...
  7. Grainge I, Lesterlin C, Sherratt D. Activation of XerCD-dif recombination by the FtsK DNA translocase. Nucleic Acids Res. 2011;39:5140-8 pubmed publisher
    The FtsK translocase pumps dsDNA directionally at ?5 kb/s and facilitates chromosome unlinking by activating XerCD site-specific recombination at dif, located in the replication terminus of the Escherichia coli chromosome...
  8. Recchia G, Aroyo M, Wolf D, Blakely G, Sherratt D. FtsK-dependent and -independent pathways of Xer site-specific recombination. EMBO J. 1999;18:5724-34 pubmed
    ..We demonstrate that Xer recombination at plasmid dif sites occurs efficiently only when FtsK is present and under conditions that allow chromosomal dimer formation, whereas recombination at the plasmid sites ..
  9. Sivanathan V, Emerson J, Pages C, Cornet F, Sherratt D, Arciszewska L. KOPS-guided DNA translocation by FtsK safeguards Escherichia coli chromosome segregation. Mol Microbiol. 2009;71:1031-42 pubmed publisher
    The septum-located DNA translocase, FtsK, acts to co-ordinate the late steps of Escherichia coli chromosome segregation with cell division...

More Information

Publications68

  1. Saleh O, Pérals C, Barre F, Allemand J. Fast, DNA-sequence independent translocation by FtsK in a single-molecule experiment. EMBO J. 2004;23:2430-9 pubmed
    Escherichia coli FtsK is an essential cell division protein, which is thought to pump chromosomal DNA through the closing septum in an oriented manner by following DNA sequence polarity...
  2. Graham J, Sivanathan V, Sherratt D, Arciszewska L. FtsK translocation on DNA stops at XerCD-dif. Nucleic Acids Res. 2010;38:72-81 pubmed publisher
    Escherichia coli FtsK is a powerful, fast, double-stranded DNA translocase, which can strip proteins from DNA. FtsK acts in the late stages of chromosome segregation by facilitating sister chromosome unlinking at the division septum...
  3. Dubarry N, Barre F. Fully efficient chromosome dimer resolution in Escherichia coli cells lacking the integral membrane domain of FtsK. EMBO J. 2010;29:597-605 pubmed publisher
    ..requires the activity of a double-stranded DNA transporter anchored at the septum by an integral membrane domain, FtsK. It was proposed that the transmembrane segments of proteins of the FtsK family form pores across lipid bilayers ..
  4. Dubarry N, Possoz C, Barre F. Multiple regions along the Escherichia coli FtsK protein are implicated in cell division. Mol Microbiol. 2010;78:1088-100 pubmed publisher
    Escherichia coli FtsK is a large 1329 aa integral membrane protein, which links cell division and chromosome segregation through the respective activities of its 200 aa amino-terminal domain, FtsK(N), and its 500 aa carboxy-terminal ..
  5. Steiner W, Liu G, Donachie W, Kuempel P. The cytoplasmic domain of FtsK protein is required for resolution of chromosome dimers. Mol Microbiol. 1999;31:579-83 pubmed
    ..report here that it is not in fact cell division per se that is required for dimer resolution but the action of the cytoplasmic domain of FtsK, which is a bifunctional protein required both for cell division and for chromosome partition.
  6. Yu X, Weihe E, Margolin W. Role of the C terminus of FtsK in Escherichia coli chromosome segregation. J Bacteriol. 1998;180:6424-8 pubmed
    b>FtsK is essential for Escherichia coli cell division...
  7. Liu G, Draper G, Donachie W. FtsK is a bifunctional protein involved in cell division and chromosome localization in Escherichia coli. Mol Microbiol. 1998;29:893-903 pubmed
  8. Blakely G, May G, McCulloch R, Arciszewska L, Burke M, Lovett S, et al. Two related recombinases are required for site-specific recombination at dif and cer in E. coli K12. Cell. 1993;75:351-61 pubmed
    ..We predict that normal partition of most circular chromosomes requires the participation of site-specific recombination to convert any multimers (arising by homologous recombination) to monomers. ..
  9. Blakely G, Sherratt D. Interactions of the site-specific recombinases XerC and XerD with the recombination site dif. Nucleic Acids Res. 1994;22:5613-20 pubmed
  10. Begg K, Dewar S, Donachie W. A new Escherichia coli cell division gene, ftsK. J Bacteriol. 1995;177:6211-22 pubmed
    A mutation in a newly discovered Escherichia coli cell division gene, ftsK, causes a temperature-sensitive late-stage block in division but does not affect chromosome replication or segregation...
  11. Levy O, Ptacin J, Pease P, Gore J, Eisen M, Bustamante C, et al. Identification of oligonucleotide sequences that direct the movement of the Escherichia coli FtsK translocase. Proc Natl Acad Sci U S A. 2005;102:17618-23 pubmed
    b>FtsK from Escherichia coli is a fast and sequence-directed DNA translocase with roles in chromosome dimer resolution, segregation, and decatenation...
  12. Espeli O, Lee C, Marians K. A physical and functional interaction between Escherichia coli FtsK and topoisomerase IV. J Biol Chem. 2003;278:44639-44 pubmed
    b>FtsK and topoisomerase (Topo) IV are both involved in chromosome segregation in Escherichia coli. The former protein resides at the septal ring and is required for resolution of chromosome dimers...
  13. Di Lallo G, Fagioli M, Barionovi D, Ghelardini P, Paolozzi L. Use of a two-hybrid assay to study the assembly of a complex multicomponent protein machinery: bacterial septosome differentiation. Microbiology. 2003;149:3353-9 pubmed
    The ability of each of the nine Escherichia coli division proteins (FtsZ, FtsA, ZipA, FtsK, FtsQ, FtsL, FtsW, FtsI, FtsN) to interact with itself and with each of the remaining eight proteins was studied in 43 possible combinations of ..
  14. Barre F, Aroyo M, Colloms S, Helfrich A, Cornet F, Sherratt D. FtsK functions in the processing of a Holliday junction intermediate during bacterial chromosome segregation. Genes Dev. 2000;14:2976-88 pubmed
    ..Chromosome dimer resolution requires that dif is positioned correctly in the chromosome, and the activity of FtsK, a septum-located protein that coordinates cell division with chromosome segregation...
  15. Ptacin J, Nollmann M, Bustamante C, Cozzarelli N. Identification of the FtsK sequence-recognition domain. Nat Struct Mol Biol. 2006;13:1023-5 pubmed
    b>FtsK is a prokaryotic multidomain DNA translocase that coordinates chromosome segregation and cell division...
  16. Massey T, Aussel L, Barre F, Sherratt D. Asymmetric activation of Xer site-specific recombination by FtsK. EMBO Rep. 2004;5:399-404 pubmed
    ..XerC and XerD, acting at a specific site on the chromosome, dif, together with the cell division protein FtsK. The C-terminal domain of FtsK (FtsK(C)) is a DNA translocase implicated in helping synapsis of the dif sites and ..
  17. Yates J, Aroyo M, Sherratt D, Barre F. Species specificity in the activation of Xer recombination at dif by FtsK. Mol Microbiol. 2003;49:241-9 pubmed
    ..is performed by two tyrosine recombinases, XerC and XerD, and requires the action of an additional protein, FtsK. We show that Haemophilus influenzae FtsK activates recombination by H. influenzae XerCD at H. influenzae dif...
  18. Blakely G, Colloms S, May G, Burke M, Sherratt D. Escherichia coli XerC recombinase is required for chromosomal segregation at cell division. New Biol. 1991;3:789-98 pubmed
  19. Aussel L, Barre F, Aroyo M, Stasiak A, Stasiak A, Sherratt D. FtsK Is a DNA motor protein that activates chromosome dimer resolution by switching the catalytic state of the XerC and XerD recombinases. Cell. 2002;108:195-205 pubmed
    b>FtsK acts at the bacterial division septum to couple chromosome segregation with cell division...
  20. Yates J, Zhekov I, Baker R, Eklund B, Sherratt D, Arciszewska L. Dissection of a functional interaction between the DNA translocase, FtsK, and the XerD recombinase. Mol Microbiol. 2006;59:1754-66 pubmed
    ..This reaction requires the DNA translocase, FtsK(C), which activates dimer resolution by catalysing an ATP hydrolysis-dependent switch in the catalytic state of the ..
  21. Leslie N, Sherratt D. Site-specific recombination in the replication terminus region of Escherichia coli: functional replacement of dif. EMBO J. 1995;14:1561-70 pubmed
  22. Lowe J, Ellonen A, Allen M, Atkinson C, Sherratt D, Grainge I. Molecular mechanism of sequence-directed DNA loading and translocation by FtsK. Mol Cell. 2008;31:498-509 pubmed publisher
    ..at the Escherichia coli dif site converts these dimers to monomers in a reaction that requires the DNA translocase FtsK. Short DNA sequences, KOPS (GGGNAGGG), which are polarized toward dif in the chromosome, direct FtsK translocation...
  23. Bigot S, Sivanathan V, Possoz C, Barre F, Cornet F. FtsK, a literate chromosome segregation machine. Mol Microbiol. 2007;64:1434-41 pubmed
    ..Here, we review one of such factor, the FtsK DNA translocase. FtsK couples segregation of the chromosome terminus, the ter region, with cell division...
  24. Yu X, Tran A, Sun Q, Margolin W. Localization of cell division protein FtsK to the Escherichia coli septum and identification of a potential N-terminal targeting domain. J Bacteriol. 1998;180:1296-304 pubmed
    Escherichia coli cell division protein FtsK is a homolog of Bacillus subtilis SpoIIIE and appears to act late in the septation process...
  25. Stouf M, Meile J, Cornet F. FtsK actively segregates sister chromosomes in Escherichia coli. Proc Natl Acad Sci U S A. 2013;110:11157-62 pubmed publisher
    ..In these special cases, the divisome-associated DNA translocase FtsK is required...
  26. Grainge I, Bregu M, Vazquez M, Sivanathan V, Ip S, Sherratt D. Unlinking chromosome catenanes in vivo by site-specific recombination. EMBO J. 2007;26:4228-38 pubmed
    ..or Cre-loxP can unlink bacterial chromosomes in vivo, in reactions that require KOPS-guided DNA translocation by FtsK. Furthermore, we show that overexpression of a cytoplasmic FtsK derivative is sufficient to allow chromosome ..
  27. Bigot S, Saleh O, Lesterlin C, Pages C, El Karoui M, Dennis C, et al. KOPS: DNA motifs that control E. coli chromosome segregation by orienting the FtsK translocase. EMBO J. 2005;24:3770-80 pubmed
    ..of two tyrosine recombinases, XerC and XerD, acting at a specific chromosomal site, dif, and a DNA translocase, FtsK, which is anchored at the division septum and sorts chromosomal DNA to daughter cells...
  28. Geissler B, Margolin W. Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK. Mol Microbiol. 2005;58:596-612 pubmed
    ..Many of these proteins, including FtsK, are essential for viability but their functions in cell division are unknown...
  29. Capiaux H, Lesterlin C, Pérals K, Louarn J, Cornet F. A dual role for the FtsK protein in Escherichia coli chromosome segregation. EMBO Rep. 2002;3:532-6 pubmed
    b>FtsK is a multifunctional protein that acts in Escherichia coli cell division and chromosome segregation...
  30. Bigot S, Saleh O, Cornet F, Allemand J, Barre F. Oriented loading of FtsK on KOPS. Nat Struct Mol Biol. 2006;13:1026-8 pubmed
    In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of ..
  31. Wang X, Possoz C, Sherratt D. Dancing around the divisome: asymmetric chromosome segregation in Escherichia coli. Genes Dev. 2005;19:2367-77 pubmed
    ..In the latter half of S phase, ter moves quickly toward mid-cell. FtsK, which coordinates the late stages of chromosome segregation with cell division, forms a ring coincident with the ..
  32. Iyer L, Makarova K, Koonin E, Aravind L. Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. Nucleic Acids Res. 2004;32:5260-79 pubmed
    ..In this study, the FtsK-HerA superfamily of P-loop ATPases, in which the HerA clade comprises one of the major branches, is analyzed in ..
  33. Bonné L, Bigot S, Chevalier F, Allemand J, Barre F. Asymmetric DNA requirements in Xer recombination activation by FtsK. Nucleic Acids Res. 2009;37:2371-80 pubmed publisher
    ..Recombination depends on a direct contact between XerD and a cell division protein, FtsK, which functions as a hexameric double stranded DNA translocase...
  34. Saleh O, Bigot S, Barre F, Allemand J. Analysis of DNA supercoil induction by FtsK indicates translocation without groove-tracking. Nat Struct Mol Biol. 2005;12:436-40 pubmed
    b>FtsK is a bacterial protein that translocates DNA in order to transport chromosomes within the cell. During translocation, DNA's double-helical structure might cause a relative rotation between FtsK and the DNA...
  35. Kuempel P, Henson J, Dircks L, Tecklenburg M, Lim D. dif, a recA-independent recombination site in the terminus region of the chromosome of Escherichia coli. New Biol. 1991;3:799-811 pubmed
    ..It is proposed that dif functions to resolve dimeric chromosomes produced by sister chromatid exchange, and that the Dif phenotype is due to the inability of these mutants to resolve multimers prior to cell division. ..
  36. Sherratt D, Arciszewska L, Crozat E, Graham J, Grainge I. The Escherichia coli DNA translocase FtsK. Biochem Soc Trans. 2010;38:395-8 pubmed publisher
    Escherichia coli FtsK is a septum-located DNA translocase that co-ordinates the late stages of cytokinesis and chromosome segregation...
  37. Pérals K, Capiaux H, Vincourt J, Louarn J, Sherratt D, Cornet F. Interplay between recombination, cell division and chromosome structure during chromosome dimer resolution in Escherichia coli. Mol Microbiol. 2001;39:904-13 pubmed
    ..dif sites catalysed by the XerCD recombinase, cell division and the integrity of the division septum-associated FtsK protein and the presence of dif inside a restricted region of the chromosome terminus, the dif activity zone (DAZ)...
  38. Ip S, Bregu M, Barre F, Sherratt D. Decatenation of DNA circles by FtsK-dependent Xer site-specific recombination. EMBO J. 2003;22:6399-407 pubmed
    ..vitro, which uses the combination of the Escherichia coli XerCD site-specific recombination system and a protein, FtsK, which facilitates simple synapsis of dif recombination sites during its translocation along DNA...
  39. Corre J, Louarn J. Extent of the activity domain and possible roles of FtsK in the Escherichia coli chromosome terminus. Mol Microbiol. 2005;56:1539-48 pubmed
    Escherichia coli FtsK protein couples cell division and chromosome segregation. It is a component of the septum essential for cell division...
  40. Pease P, Levy O, Cost G, Gore J, Ptacin J, Sherratt D, et al. Sequence-directed DNA translocation by purified FtsK. Science. 2005;307:586-90 pubmed
    ..We directly observed the movement of purified FtsK, an Escherichia coli translocase, on single DNA molecules...
  41. Massey T, Mercogliano C, Yates J, Sherratt D, L we J. Double-stranded DNA translocation: structure and mechanism of hexameric FtsK. Mol Cell. 2006;23:457-69 pubmed publisher
    b>FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria...
  42. Lesterlin C, Barre F, Cornet F. Genetic recombination and the cell cycle: what we have learned from chromosome dimers. Mol Microbiol. 2004;54:1151-60 pubmed
    ..Here, we briefly review these advances and highlight the important questions they raise. ..
  43. Bigot S, Corre J, Louarn J, Cornet F, Barre F. FtsK activities in Xer recombination, DNA mobilization and cell division involve overlapping and separate domains of the protein. Mol Microbiol. 2004;54:876-86 pubmed
    Escherichia coli FtsK is a multifunctional protein that couples cell division and chromosome segregation...
  44. D Ulisse V, Fagioli M, Ghelardini P, Paolozzi L. Three functional subdomains of the Escherichia coli FtsQ protein are involved in its interaction with the other division proteins. Microbiology. 2007;153:124-38 pubmed publisher
    ..In this third region, the interaction site for FtsK and also the second site for FtsQ, FtsI, FtsN interactions are located...
  45. Grenga L, Luzi G, Paolozzi L, Ghelardini P. The Escherichia coli FtsK functional domains involved in its interaction with its divisome protein partners. FEMS Microbiol Lett. 2008;287:163-7 pubmed publisher
    b>FtsK is a multifunctional protein involved in both cell division and chromosome segregation...
  46. Li Y, Youngren B, Sergueev K, Austin S. Segregation of the Escherichia coli chromosome terminus. Mol Microbiol. 2003;50:825-34 pubmed
    ..Resolution of chromosome dimers via the terminus dif site requires the XerC recombinase and an activity of the FtsK protein that is thought to align the dif sequences at the cell centre...
  47. Lau I, Filipe S, Søballe B, Økstad O, Barre F, Sherratt D. Spatial and temporal organization of replicating Escherichia coli chromosomes. Mol Microbiol. 2003;49:731-43 pubmed
    ..This asymmetry could provide a mechanism by which the chromosome segregation protein FtsK, located at the division septum, can act directionally to ensure that the septal region is free of DNA before the ..
  48. Sherratt D, Søballe B, Barre F, Filipe S, Lau I, Massey T, et al. Recombination and chromosome segregation. Philos Trans R Soc Lond B Biol Sci. 2004;359:61-9 pubmed
    ..Dimer resolution also requires FtsK, a division septum-located protein, which coordinates chromosome segregation with cell division, and uses the ..
  49. Maggi S, Massidda O, Luzi G, Fadda D, Paolozzi L, Ghelardini P. Division protein interaction web: identification of a phylogenetically conserved common interactome between Streptococcus pneumoniae and Escherichia coli. Microbiology. 2008;154:3042-52 pubmed publisher
    ..At least nine division proteins, ZapA, FtsZ, FtsA, FtsK, FtsQ/DivIB, FtsB/DivIC, FtsL, FtsI and FtsW, are believed to have a conserved function between these bacteria and ..
  50. Hale C, de Boer P. ZipA is required for recruitment of FtsK, FtsQ, FtsL, and FtsN to the septal ring in Escherichia coli. J Bacteriol. 2002;184:2552-6 pubmed
    ..FtsA and ZipA directly bind FtsZ polymers at the prospective division site, followed by the sequential addition of FtsK, FtsQ, FtsL, FtsW, FtsI, and FtsN...
  51. Diez A, Gustavsson N, Nystr m T. The universal stress protein A of Escherichia coli is required for resistance to DNA damaging agents and is regulated by a RecA/FtsK-dependent regulatory pathway. Mol Microbiol. 2000;36:1494-503 pubmed
    ..An insertion in the cell division gene ftsK upregulates uspA in a recA-dependent manner...
  52. Colloms S, Sykora P, Szatmari G, Sherratt D. Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases. J Bacteriol. 1990;172:6973-80 pubmed
    ..The xerC gene is expressed as part of a multicistronic unit that includes the dapF gene and two other open reading frames. ..
  53. Galli E, Midonet C, Paly E, Barre F. Fast growth conditions uncouple the final stages of chromosome segregation and cell division in Escherichia coli. PLoS Genet. 2017;13:e1006702 pubmed publisher
    ..The reaction is under the control of a cell division protein, FtsK, which assembles into active DNA pumps at mid-cell during septum formation...
  54. Bernard C, Sadasivam M, Shiomi D, Margolin W. An altered FtsA can compensate for the loss of essential cell division protein FtsN in Escherichia coli. Mol Microbiol. 2007;64:1289-305 pubmed
    ..Remarkably, these altered FtsA proteins also could partially suppress a deletion of ftsK or zipA, were less toxic than wild-type FtsA when in excess, and conferred resistance to excess MinC, indicating ..
  55. Chen J, Beckwith J. FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division. Mol Microbiol. 2001;42:395-413 pubmed
    ..Escherichia coli, at least nine essential gene products participate directly in septum formation: FtsA, FtsI, FtsL, FtsK, FtsN, FtsQ, FtsW, FtsZ and ZipA...
  56. Lindstedt B, Brandal L, Aas L, Vardund T, Kapperud G. Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay. J Microbiol Methods. 2007;69:197-205 pubmed
    ..Shigella isolates were of species S. flexneri, S. boydii, S. sonnei and S. dysenteriae. The MLVA method rapidly genotyped all isolates in the study at a Simpson's index of diversity of D=0.98...
  57. Diez A, Tunlid A, Nystrom T. The Escherichia coli ftsK1 mutation attenuates the induction of sigma(S)-dependent genes upon transition to stationary phase. FEMS Microbiol Lett. 2002;206:19-23 pubmed
    A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase...
  58. Buddelmeijer N, Beckwith J. A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region. Mol Microbiol. 2004;52:1315-27 pubmed
    ..However, FtsQ is found at the cell division site in the absence of FtsL and FtsB. FtsQ, in turn, requires FtsK for its localization. Here, we show that FtsL, FtsB and FtsQ form a complex in vivo...
  59. Hojgaard A, Szerlong H, Tabor C, Kuempel P. Norfloxacin-induced DNA cleavage occurs at the dif resolvase locus in Escherichia coli and is the result of interaction with topoisomerase IV. Mol Microbiol. 1999;33:1027-36 pubmed
    ..at dif resolves circular dimer chromosomes to monomers, and this recombination requires the XerC, XerD and FtsK proteins, as well as cell division...