ftsE

Summary

Gene Symbol: ftsE
Description: cell division ATP-binding protein
Alias: ECK3447, JW3428
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Arends S, Kustusch R, Weiss D. ATP-binding site lesions in FtsE impair cell division. J Bacteriol. 2009;191:3772-84 pubmed publisher
    b>FtsE and FtsX of Escherichia coli constitute an apparent ABC transporter that localizes to the septal ring...
  2. Taschner P, Huls P, Pas E, Woldringh C. Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments. J Bacteriol. 1988;170:1533-40 pubmed
    Isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli were compared with their parent strain in temperature shift experiments...
  3. Gibbs T, Gill D, Salmond G. Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of hum. Mol Gen Genet. 1992;234:121-8 pubmed
    ..mutants had a filamentation temperature sensitive (fts) phenotype and were assigned to the cell division genes ftsE of ftsX, whereas others were defective in the heat shock regulator gene rpoH...
  4. Vicente M, Rico A. The order of the ring: assembly of Escherichia coli cell division components. Mol Microbiol. 2006;61:5-8 pubmed
    ..In addition, back-recruitment of all late proteins except FtsN into the division ring occurs even in the absence of proteins incorporated at earlier stages, i.e. FtsA or FtsQ. ..
  5. Gill D, Salmond G. The Escherichia coli cell division proteins FtsY, FtsE and FtsX are inner membrane-associated. Mol Gen Genet. 1987;210:504-8 pubmed
    The cell division genes ftsY, ftsE and ftsX form an operon mapping at 76 min on the Escherichia coli chromosome. The protein products of these genes have been identified previously...
  6. Miller J, Bernstein H, Walter P. Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor. Nature. 1994;367:657-9 pubmed
    ..These properties mimic those of mammalian SRP and its receptor, suggesting that the E. coli Ffh/4.5S ribonucleoprotein and FtsY have functions in protein targeting that are similar to those of their mammalian counterparts. ..
  7. Aarsman M, Piette A, Fraipont C, Vinkenvleugel T, Nguyen Dist├Ęche M, Den Blaauwen T. Maturation of the Escherichia coli divisome occurs in two steps. Mol Microbiol. 2005;55:1631-45 pubmed
    Cell division proteins FtsZ (FtsA, ZipA, ZapA), FtsE/X, FtsK, FtsQ, FtsL/B, FtsW, PBP3, FtsN and AmiC localize at mid cell in Escherichia coli in an interdependent order as listed...
  8. De Leeuw E, Graham B, Phillips G, Ten Hagen Jongman C, Oudega B, Luirink J. Molecular characterization of Escherichia coli FtsE and FtsX. Mol Microbiol. 1999;31:983-93 pubmed
    The genes ftsE and ftsX are organized in one operon together with ftsY. FtsY codes for the receptor of the signal recognition particle (SRP) that functions in targeting a subset of inner membrane proteins...
  9. Du S, Pichoff S, Lutkenhaus J. FtsEX acts on FtsA to regulate divisome assembly and activity. Proc Natl Acad Sci U S A. 2016;113:E5052-61 pubmed publisher
    ..Furthermore, our study provides evidence that FtsA mutants impaired for self-interaction are favored for division, and FtsW plays a critical role in divisome activation in addition to the FtsQLB complex. ..

More Information

Publications21

  1. Samaluru H, SaiSree L, Reddy M. Role of SufI (FtsP) in cell division of Escherichia coli: evidence for its involvement in stabilizing the assembly of the divisome. J Bacteriol. 2007;189:8044-52 pubmed
    ..Since sufI fulfils the requirements to be designated an fts gene, we propose that it be renamed ftsP. ..
  2. Fujiwara K, Taguchi H. Filamentous morphology in GroE-depleted Escherichia coli induced by impaired folding of FtsE. J Bacteriol. 2007;189:5860-6 pubmed
    ..Among the candidate substrates, we found that prior excess production of FtsE, a protein engaged in cell division, completely suppressed the filamentation of GroE-depleted E. coli...
  3. Corbin B, Wang Y, Beuria T, Margolin W. Interaction between cell division proteins FtsE and FtsZ. J Bacteriol. 2007;189:3026-35 pubmed
    b>FtsE and FtsX, which are widely conserved homologs of ABC transporters and interact with each other, have important but unknown functions in bacterial cell division...
  4. Schmidt K, Peterson N, Kustusch R, Wissel M, Graham B, Phillips G, et al. A predicted ABC transporter, FtsEX, is needed for cell division in Escherichia coli. J Bacteriol. 2004;186:785-93 pubmed
    b>FtsE and FtsX have homology to the ABC transporter superfamily of proteins and appear to be widely conserved among bacteria...
  5. Ricard M, Hirota Y. Process of cellular division in Escherichia coli: physiological study on thermosensitive mutants defective in cell division. J Bacteriol. 1973;116:314-22 pubmed
    ..The existence of three types of mutants was shown. The ftsA and ftsE mutants resumed cell division without new protein synthesis; ftsD mutants resumed cell division only if new protein ..
  6. Crickmore N, Salmond G. The Escherichia coli heat shock regulatory gene is immediately downstream of a cell division operon: the fam mutation is allelic with rpoH. Mol Gen Genet. 1986;205:535-9 pubmed
    ..We also show that the fam-715 mutation is allelic with rpoH and so the conditional lipoprotein deficiency of the fam mutation must be due to the pleiotropic nature of the heat shock response. ..
  7. Gill D, Salmond G. The identification of the Escherichia coli ftsY gene product: an unusual protein. Mol Microbiol. 1990;4:575-83 pubmed
    The ftsYEX operon in Escherichia coli encodes three proteins, two of which (FtsE and FtsX) are known to be required for cell division. Although FtsE and FtsX have been identified using SDS-PAGE, the FtsY protein has not...
  8. Ukai H, Matsuzawa H, Ito K, Yamada M, Nishimura A. ftsE(Ts) affects translocation of K+-pump proteins into the cytoplasmic membrane of Escherichia coli. J Bacteriol. 1998;180:3663-70 pubmed
    The ftsE(Ts) mutation of Escherichia coli causes defects in cell division and cell growth...
  9. Reddy M. Role of FtsEX in cell division of Escherichia coli: viability of ftsEX mutants is dependent on functional SufI or high osmotic strength. J Bacteriol. 2007;189:98-108 pubmed
    In Escherichia coli, at least 12 proteins, FtsZ, ZipA, FtsA, FtsE/X, FtsK, FtsQ, FtsL, FtsB, FtsW, FtsI, FtsN, and AmiC, are known to localize to the septal ring in an interdependent and sequential pathway to coordinate the septum ..
  10. Salmond G, Plakidou S. Genetic analysis of essential genes in the ftsE region of the Escherichia coli genetic map and identification of a new cell division gene, ftsS. Mol Gen Genet. 1984;197:304-8 pubmed
    ..Three temperature-sensitive ftsE mutants were found as was a cold-sensitive ftsE mutant...
  11. Gill D, Hatfull G, Salmond G. A new cell division operon in Escherichia coli. Mol Gen Genet. 1986;205:134-45 pubmed
    ..This common domain is indicative of a nucleotide-binding site. ..
  12. Goehring N, Gonzalez M, Beckwith J. Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly. Mol Microbiol. 2006;61:33-45 pubmed
    ..Based on these observations we present a revised model for assembly of the E. coli division apparatus. ..