ftsB

Summary

Gene Symbol: ftsB
Description: cell division protein
Alias: ECK2743, JW2718, ygbQ
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Errington J, Daniel R, Scheffers D. Cytokinesis in bacteria. Microbiol Mol Biol Rev. 2003;67:52-65, table of contents pubmed
    ..The functions of most of these proteins are unclear with the exception of at least one penicillin-binding protein, which catalyzes a key step in cell wall synthesis in the division septum. ..
  2. Gonzalez M, Beckwith J. Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins. J Bacteriol. 2009;191:2815-25 pubmed publisher
    ..Within the Escherichia coli divisome is a conserved subcomplex of inner membrane proteins, the FtsB/FtsL/FtsQ complex, which is necessary for linking the upstream division proteins, which are predominantly ..
  3. van den Ent F, Vinkenvleugel T, Ind A, West P, Veprintsev D, Nanninga N, et al. Structural and mutational analysis of the cell division protein FtsQ. Mol Microbiol. 2008;68:110-23 pubmed publisher
    ..that localize FtsQ need the second beta-strand of the POTRA domain and those that are recruited by FtsQ, like FtsL/FtsB, require the surface formed by the tip of the last alpha-helix and the two C-terminal beta-strands...
  4. Gonzalez M, Akbay E, Boyd D, Beckwith J. Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex. J Bacteriol. 2010;192:2757-68 pubmed publisher
    ..indicates that the overwhelming majority of bacteria possess homologs of the Escherichia coli proteins FtsL, FtsB, and FtsQ, three proteins essential for cell division in that bacterium...
  5. Scheffers D, Robichon C, Haan G, Den Blaauwen T, Koningstein G, van Bloois E, et al. Contribution of the FtsQ transmembrane segment to localization to the cell division site. J Bacteriol. 2007;189:7273-80 pubmed
    ..functionally insert into the membrane, whereas another mutant (L29/32R) was correctly assembled and interacted with FtsB and FtsL but failed to localize efficiently to the cell division site...
  6. D Ulisse V, Fagioli M, Ghelardini P, Paolozzi L. Three functional subdomains of the Escherichia coli FtsQ protein are involved in its interaction with the other division proteins. Microbiology. 2007;153:124-38 pubmed publisher
    ..Escherichia coli divisome assembly, is able to interact with various division proteins, namely FtsI, FtsL, FtsN, FtsB and FtsW...
  7. Goehring N, Petrovska I, Boyd D, Beckwith J. Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly. J Bacteriol. 2007;189:633-45 pubmed
    ..of these proteins, FtsQ, is physically associated with multiple essential division proteins, including FtsK, FtsL, FtsB, FtsW, and FtsI. In this work we performed a genetic analysis of the ftsQ gene...
  8. Buddelmeijer N, Judson N, Boyd D, Mekalanos J, Beckwith J. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proc Natl Acad Sci U S A. 2002;99:6316-21 pubmed publisher
    b>YgbQ is a cell division protein in Escherichia coli and Vibrio cholerae. In E. coli the ygbQ gene was discovered as a result of a computer search of the E...
  9. Goehring N, Gonzalez M, Beckwith J. Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly. Mol Microbiol. 2006;61:33-45 pubmed
    ..Based on these observations we present a revised model for assembly of the E. coli division apparatus. ..

More Information

Publications21

  1. Karimova G, Dautin N, Ladant D. Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis. J Bacteriol. 2005;187:2233-43 pubmed
    ..In addition, our study shows that the cAMP-based two-hybrid system is particularly appropriate for analyzing molecular interactions between membrane proteins. ..
  2. Buddelmeijer N, Beckwith J. A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region. Mol Microbiol. 2004;52:1315-27 pubmed
    Three membrane proteins required for cell division in Escherichia coli, FtsQ, FtsL and FtsB, localize to the cell septum...
  3. Geissler B, Margolin W. Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK. Mol Microbiol. 2005;58:596-612 pubmed
    ..Cells expressing additional ftsQ, and to a lesser extent ftsB and ftsN, were able to survive and divide in the absence of ftsK, although cell chains were often formed...
  4. Weiss D. Bacterial cell division and the septal ring. Mol Microbiol. 2004;54:588-97 pubmed
    ..Finally, two murein hydrolases, AmiC and EnvC, have been shown to localize to the septal ring of Escherichia coli, where they play an important role in separation of daughter cells. ..
  5. Villanelo F, Ordenes A, BRUNET J, Lagos R, Monasterio O. A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex. BMC Struct Biol. 2011;11:28 pubmed publisher
    ..The proteins involved in connecting both steps in cell division are FtsQ, FtsB and FtsL, and their interaction is a crucial and conserved event in the division of different bacteria...
  6. Robichon C, Karimova G, Beckwith J, Ladant D. Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB. J Bacteriol. 2011;193:4988-92 pubmed publisher
    FtsL and FtsB are two inner-membrane proteins that are essential constituents of the cell division apparatus of Escherichia coli...
  7. Vicente M, Rico A. The order of the ring: assembly of Escherichia coli cell division components. Mol Microbiol. 2006;61:5-8 pubmed
    ..In addition, back-recruitment of all late proteins except FtsN into the division ring occurs even in the absence of proteins incorporated at earlier stages, i.e. FtsA or FtsQ. ..
  8. Aarsman M, Piette A, Fraipont C, Vinkenvleugel T, Nguyen Dist├Ęche M, Den Blaauwen T. Maturation of the Escherichia coli divisome occurs in two steps. Mol Microbiol. 2005;55:1631-45 pubmed
  9. Maggi S, Massidda O, Luzi G, Fadda D, Paolozzi L, Ghelardini P. Division protein interaction web: identification of a phylogenetically conserved common interactome between Streptococcus pneumoniae and Escherichia coli. Microbiology. 2008;154:3042-52 pubmed publisher
    ..At least nine division proteins, ZapA, FtsZ, FtsA, FtsK, FtsQ/DivIB, FtsB/DivIC, FtsL, FtsI and FtsW, are believed to have a conserved function between these bacteria and thus we may say ..
  10. Ricard M, Hirota Y. Process of cellular division in Escherichia coli: physiological study on thermosensitive mutants defective in cell division. J Bacteriol. 1973;116:314-22 pubmed
    ..without new protein synthesis; ftsD mutants resumed cell division only if new protein synthesis occured, while ftsB, C, F and G mutants did not resume cell division at all...
  11. Lapointe L, Taylor K, Subramaniam S, Khadria A, Rayment I, Senes A. Structural organization of FtsB, a transmembrane protein of the bacterial divisome. Biochemistry. 2013;52:2574-85 pubmed publisher
    We report the first structural analysis of an integral membrane protein of the bacterial divisome. FtsB is a single-pass membrane protein with a periplasmic coiled coil...
  12. Tsang M, Bernhardt T. A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division. Mol Microbiol. 2015;95:925-44 pubmed publisher
    ..Our results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes needed ..