Gene Symbol: fliZ
Description: RpoS antagonist; putative regulator of FliA activity
Alias: ECK1920, JW1906, yedH
Species: Escherichia coli str. K-12 substr. MG1655
Liu X, Matsumura P. An alternative sigma factor controls transcription of flagellar class-III operons in Escherichia coli: gene sequence, overproduction, purification and characterization. Gene. 1995;164:81-4 pubmed
..The purified protein was able to initiate transcription from the tar promoter in the presence of RNP core enzyme. We conclude that FliA functions as an alternative sigma factor sigma 28 which is specific for flagellar operons in Ec. ..
Chilcott G, Hughes K. Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar typhimurium and Escherichia coli. Microbiol Mol Biol Rev. 2000;64:694-708 pubmed
..Cell cycle control and flagellar development are codependent. We discuss how all these levels of regulation ensure efficient assembly of the flagellum in response to environmental stimuli. ..
Girgis H, Liu Y, Ryu W, Tavazoie S. A comprehensive genetic characterization of bacterial motility. PLoS Genet. 2007;3:1644-60 pubmed
..This unifying framework enables sensitive and comprehensive genetic characterization of complex behaviors across the microbial biosphere. ..
Pesavento C, Becker G, Sommerfeldt N, Possling A, Tschowri N, Mehlis A, et al
. Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli. Genes Dev. 2008;22:2434-46 pubmed publisher
..coordinated by sigma(70)/sigma(FliA)/sigma(S) competition for core RNA polymerase and the FlhDC-controlled FliZ protein acting as a sigma(S) inhibitor...
Pesavento C, Hengge R. The global repressor FliZ antagonizes gene expression by ?S-containing RNA polymerase due to overlapping DNA binding specificity. Nucleic Acids Res. 2012;40:4783-93 pubmed publisher
b>FliZ, a global regulatory protein under the control of the flagellar master regulator FlhDC, was shown to antagonize ?(S)-dependent gene expression in Escherichia coli...
Mytelka D, Chamberlin M. Escherichia coli fliAZY operon. J Bacteriol. 1996;178:24-34 pubmed
..coli fliAZY operon, which contains the fliA gene (the alternative sigma factor sigma F) and two novel genes, fliZ and fliY...
Mitra A, Fay P, Vendura K, Alla Z, Carroll R, Shaw L, et al
. ?(N) -dependent control of acid resistance and the locus of enterocyte effacement in enterohemorrhagic Escherichia coli is activated by acetyl phosphate in a manner requiring flagellar regulator FlhDC and the ?(S) antagonist FliZ. Microbiologyopen. 2014;3:497-512 pubmed publisher
..Deletion of fliZ, the product of which reduces ?(S) activity, phenocopied rpoN (?(N)) and ntrC null strains for GDAR and LEE control,..
Bertin P, Terao E, Lee E, Lejeune P, Colson C, Danchin A, et al
. The H-NS protein is involved in the biogenesis of flagella in Escherichia coli. J Bacteriol. 1994;176:5537-40 pubmed
..These results suggest that the H-NS protein acts as a positive regulator of genes involved in the biogenesis of flagella by a mechanism independent of the cAMP-CAP pathway. ..