Gene Symbol: fliK
Description: flagellar hook-length control protein
Alias: ECK1941, JW1927, flaE
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Kawagishi I, Muller V, Williams A, Irikura V, Macnab R. Subdivision of flagellar region III of the Escherichia coli and Salmonella typhimurium chromosomes and identification of two additional flagellar genes. J Gen Microbiol. 1992;138:1051-65 pubmed
    ..The functions of FliS and FliT remain to be determined, but they do not appear to be members of the axial family of structural proteins to which FliD belongs. ..
  2. Al Mamun A, Tominaga A, Enomoto M. Cloning and characterization of the region III flagellar operons of the four Shigella subgroups: genetic defects that cause loss of flagella of Shigella boydii and Shigella sonnei. J Bacteriol. 1997;179:4493-500 pubmed
    ..We also discuss the process of loss of flagella in relation to transposition of IS elements and alterations of the noncoding region, which were found to be common to at least three subgroups...
  3. Kubori T, Sukhan A, Aizawa S, Galan J. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system. Proc Natl Acad Sci U S A. 2000;97:10225-30 pubmed
    ..We hypothesize that the needle component may establish the specificity of type III secretion systems in delivering proteins into either plant or animal cells. ..
  4. Pallen M, Penn C, Chaudhuri R. Bacterial flagellar diversity in the post-genomic era. Trends Microbiol. 2005;13:143-9 pubmed
    ..Numerous previously unrecognized homologues of flagellar components were discovered, including novel FlgM, FlgN, FliK and FliO homologues...
  5. Minamino T, Ferris H, Moriya N, Kihara M, Namba K. Two parts of the T3S4 domain of the hook-length control protein FliK are essential for the substrate specificity switching of the flagellar type III export apparatus. J Mol Biol. 2006;362:1148-58 pubmed
    ..interaction of the type III secretion substrate specificity switch (T3S4) domain of the hook-length control protein FliK, with the integral membrane export apparatus component FlhB...
  6. Bartlett D, Matsumura P. Identification of Escherichia coli region III flagellar gene products and description of two new flagellar genes. J Bacteriol. 1984;160:577-85 pubmed
    ..flagellar mutants and code for polypeptides, we made the following gene product assignments: flaB 1, 60 kilodaltons; flaB 11, 38 kilodaltons; flaB111, 28 kilodaltons; flaC, 56 kilodaltons; fla0, 16 kilodaltons; and flaE, 54 kilodaltons.
  7. Kawagishi I, Homma M, Williams A, Macnab R. Characterization of the flagellar hook length control protein fliK of Salmonella typhimurium and Escherichia coli. J Bacteriol. 1996;178:2954-9 pubmed
    During flagellar morphogenesis in Salmonella typhimurium and Escherichia coli, the fliK gene product is responsible for hook length control. A previous study (M. Homma, T. Iino, and R. M. Macnab, J. Bacteriol...
  8. Minamino T, Macnab R. Domain structure of Salmonella FlhB, a flagellar export component responsible for substrate specificity switching. J Bacteriol. 2000;182:4906-14 pubmed
    ..FlhB, along with the hook-length control protein FliK, mediates the switching of export specificity from rod- and hook-type substrates to filament-type substrates during ..
  9. Hashimoto M, Mashimo T, Hirano T, Yamaguchi S, Aizawa S. Functional roles of the hook in a rotating tethered cell. J Mol Biol. 2008;375:367-75 pubmed
    ..These observations indicate that tethered cells almost always interact with the glass surface in one cycle of rotation, where the length and flexibility of the hook have an important role. ..

More Information


  1. Makishima S, Komoriya K, Yamaguchi S, Aizawa S. Length of the flagellar hook and the capacity of the type III export apparatus. Science. 2001;291:2411-3 pubmed
    ..The export apparatus shares common features with the type III virulence-factor secretion machinery and thus may be used more widely in length determination of structures other than flagella. ..