flgK

Summary

Gene Symbol: flgK
Description: flagellar hook-filament junction protein 1
Alias: ECK1067, JW1069, flaS
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Ikeda T, Homma M, Iino T, Asakura S, Kamiya R. Localization and stoichiometry of hook-associated proteins within Salmonella typhimurium flagella. J Bacteriol. 1987;169:1168-73 pubmed
    ..Analysis of the protein composition of short flagella from a mutant indicated that a single flagellum contains about 10 to 20 HAP1, 10 to 20 HAP2, and 10 to 40 HAP3 molecules. ..
  2. Komeda Y, Silverman M, Matsumura P, Simon M. Genes for the hook-basal body proteins of the flagellar apparatus in Escherichia coli. J Bacteriol. 1978;134:655-67 pubmed
    ..The synthesis of all of these polypeptides was regulated by the same mechanism that regulates the synthesis of other flagellar-related structural components. ..
  3. Suzuki T, Komeda Y. Incomplete flagellar structures in Escherichia coli mutants. J Bacteriol. 1981;145:1036-41 pubmed
    ..Hook-basal body structures were detected in flaD, flaS, flaT, flbC, and hag mutants. The flaE mutant had a polyhook-basal body structure...
  4. Fahrner K, Block S, Krishnaswamy S, Parkinson J, Berg H. A mutant hook-associated protein (HAP3) facilitates torsionally induced transformations of the flagellar filament of Escherichia coli. J Mol Biol. 1994;238:173-86 pubmed
    ..The N-terminal sequence of HAP3 was found to be similar to the N-terminal sequence of flagellin, and the possibility that it provides a nucleation site for the C-terminal region of flagellin is discussed. ..
  5. Maki Yonekura S, Yonekura K, Namba K. Domain movements of HAP2 in the cap-filament complex formation and growth process of the bacterial flagellum. Proc Natl Acad Sci U S A. 2003;100:15528-33 pubmed
  6. Komeda Y, Silverman M, Simon M. Genetic analysis of Escherichia coli K-12 region I flagellar mutants. J Bacteriol. 1977;131:801-8 pubmed
    ..Region I was shown to include at least six cistrons, flaV, flaK, flaL, flaM, flaS, and flaT. Mu-induced and deletion fla mutants were also isolated...
  7. Hasegawa K, Yamashita I, Namba K. Quasi- and nonequivalence in the structure of bacterial flagellar filament. Biophys J. 1998;74:569-75 pubmed
  8. Maki S, Vonderviszt F, Furukawa Y, Imada K, Namba K. Plugging interactions of HAP2 pentamer into the distal end of flagellar filament revealed by electron microscopy. J Mol Biol. 1998;277:771-7 pubmed
    ..This also allows us to model the axial domain arrangement of flagellin subunit in the filament. ..
  9. Yonekura K, Maki S, Morgan D, DeRosier D, Vonderviszt F, Imada K, et al. The bacterial flagellar cap as the rotary promoter of flagellin self-assembly. Science. 2000;290:2148-52 pubmed
    ..This represents one of the most dynamic movements in protein structures. ..

More Information

Publications12

  1. Rajagopala S, Hughes K, Uetz P. Benchmarking yeast two-hybrid systems using the interactions of bacterial motility proteins. Proteomics. 2009;9:5296-302 pubmed publisher
  2. Kutsukake K, Minamino T, Yokoseki T. Isolation and characterization of FliK-independent flagellation mutants from Salmonella typhimurium. J Bacteriol. 1994;176:7625-9 pubmed
    ..On the basis of these results, we discuss the mechanism of suppression of the fliK defects by the flhB mutations and propose a hypothesis on the export switching machinery of the flagellar proteins. ..
  3. Samatey F, Imada K, Nagashima S, Vonderviszt F, Kumasaka T, Yamamoto M, et al. Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling. Nature. 2001;410:331-7 pubmed
    ..By simulated extension of the protofilament model, we have identified possible switch regions responsible for the bi-stable mechanical switch that generates the 0.8 A difference in repeat distance. ..