fis

Summary

Gene Symbol: fis
Description: global DNA-binding transcriptional dual regulator
Alias: ECK3248, JW3229, nbp
Species: Escherichia coli str. K-12 substr. MG1655
Products:     fis

Top Publications

  1. Jackson L, Blake T, Green J. Regulation of ndh expression in Escherichia coli by Fis. Microbiology. 2004;150:407-13 pubmed
    ..The histone-like protein Fis binds to three sites [centred at -123 (Fis I), -72, (Fis II) and +51 (Fis III)] in the ndh promoter...
  2. Ball C, Osuna R, Ferguson K, Johnson R. Dramatic changes in Fis levels upon nutrient upshift in Escherichia coli. J Bacteriol. 1992;174:8043-56 pubmed
    b>Fis is a small basic DNA-binding protein from Escherichia coli that was identified because of its role in site-specific DNA recombination reactions...
  3. Shao Y, Feldman Cohen L, Osuna R. Functional characterization of the Escherichia coli Fis-DNA binding sequence. J Mol Biol. 2008;376:771-85 pubmed publisher
    The Escherichia coli protein Fis is remarkable for its ability to interact specifically with DNA sites of highly variable sequences. The mechanism of this sequence-flexible DNA recognition is not well understood...
  4. Grainger D, Goldberg M, Lee D, Busby S. Selective repression by Fis and H-NS at the Escherichia coli dps promoter. Mol Microbiol. 2008;68:1366-77 pubmed publisher
    ..Here we show that two other nucleoid-associated proteins, Fis and H-NS, can bind at the dps gene promoter and downregulate its activity...
  5. Schneider R, Lurz R, Luder G, Tolksdorf C, Travers A, Muskhelishvili G. An architectural role of the Escherichia coli chromatin protein FIS in organising DNA. Nucleic Acids Res. 2001;29:5107-14 pubmed
    The Escherichia coli chromatin protein FIS modulates the topology of DNA in a growth phase-dependent manner. In this study we have investigated the global effect of FIS binding on DNA architecture in vitro...
  6. Hengen P, Lyakhov I, Stewart L, Schneider T. Molecular flip-flops formed by overlapping Fis sites. Nucleic Acids Res. 2003;31:6663-73 pubmed
    The DNA-binding protein Fis frequently uses pairs of sites 7 or 11 base pairs (bp) apart. Two overlapping Fis sites separated by 11 bp are found in the Escherichia coli origin of chromosomal replication...
  7. Cho B, Knight E, Barrett C, Palsson B. Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts. Genome Res. 2008;18:900-10 pubmed publisher
    We determined the genome-wide distribution of the nucleoid-associated protein Fis in Escherichia coli using chromatin immunoprecipitation coupled with high-resolution whole genome-tiling microarrays...
  8. Grainger D, Hurd D, Goldberg M, Busby S. Association of nucleoid proteins with coding and non-coding segments of the Escherichia coli genome. Nucleic Acids Res. 2006;34:4642-52 pubmed
    ..exploited chromatin immunoprecipitation and high-density microarrays to study the binding of three such proteins, FIS, H-NS and IHF, across the E.coli genome in vivo...
  9. Pemberton I, Muskhelishvili G, Travers A, Buckle M. FIS modulates the kinetics of successive interactions of RNA polymerase with the core and upstream regions of the tyrT promoter. J Mol Biol. 2002;318:651-63 pubmed
    We have applied laser UV photo-footprinting to characterise kinetically complexes involving the activator protein FIS, RNA polymerase and the tyrT promoter of Escherichia coli...

More Information

Publications72

  1. Azam T, Hiraga S, Ishihama A. Two types of localization of the DNA-binding proteins within the Escherichia coli nucleoid. Genes Cells. 2000;5:613-26 pubmed
    ..of DNA functions accumulate at specific loci within the nucleoid, forming 2 (SeqA), 3-4 (CbpA and CbpB) and 6-10 (Fis and IciA) immuno-stained dots...
  2. Hardy C, Cozzarelli N. A genetic selection for supercoiling mutants of Escherichia coli reveals proteins implicated in chromosome structure. Mol Microbiol. 2005;57:1636-52 pubmed
    ..Three of these proteins: H-NS, Fis and DksA, have clear ties to chromosome biology...
  3. Koch C, Vandekerckhove J, Kahmann R. Escherichia coli host factor for site-specific DNA inversion: cloning and characterization of the fis gene. Proc Natl Acad Sci U S A. 1988;85:4237-41 pubmed
    The Escherichia coli (Es. coli) protein Fis (factor for inversion stimulation) stimulates site-specific DNA inversion of the G segment in phage Mu by binding to a recombinational enhancer...
  4. Mallik P, Paul B, Rutherford S, Gourse R, Osuna R. DksA is required for growth phase-dependent regulation, growth rate-dependent control, and stringent control of fis expression in Escherichia coli. J Bacteriol. 2006;188:5775-82 pubmed
    ..Given the kinetic similarities between rRNA promoters and the fis promoter (Pfis), we investigated the possibility that DksA might also control transcription from Pfis...
  5. Gille H, Egan J, Roth A, Messer W. The FIS protein binds and bends the origin of chromosomal DNA replication, oriC, of Escherichia coli. Nucleic Acids Res. 1991;19:4167-72 pubmed
    The FIS protein (factor for inversion stimulation) is known to stimulate site-specific recombination processes, such as the inversion of the G segment of bacteriophage Mu, by binding to specific enhancer sequences...
  6. Green J, Anjum M, Guest J. The ndh-binding protein (Nbp) regulates the ndh gene of Escherichia coli in response to growth phase and is identical to Fis. Mol Microbiol. 1996;20:1043-55 pubmed
    ..Protein purification and mutant studies have further shown that Nbp is identical to the Fis protein (factor for inversion stimulation)...
  7. Schneider R, Travers A, Muskhelishvili G. FIS modulates growth phase-dependent topological transitions of DNA in Escherichia coli. Mol Microbiol. 1997;26:519-30 pubmed
    The Escherichia coli DNA-binding protein FIS serves as a DNA architectural factor in two unrelated enzymatic reactions, the site-specific inversion of DNA and transcriptional activation of stable RNA promoters...
  8. Yuan H, Finkel S, Feng J, Kaczor Grzeskowiak M, Johnson R, Dickerson R. The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA binding. Proc Natl Acad Sci U S A. 1991;88:9558-62 pubmed
    The 98-amino acid Fis protein from Escherichia coli functions in a variety of reactions, including promotion of Hin-mediated site-specific DNA inversion when bound to an enhancer sequence...
  9. Skoko D, Yan J, Johnson R, Marko J. Low-force DNA condensation and discontinuous high-force decondensation reveal a loop-stabilizing function of the protein Fis. Phys Rev Lett. 2005;95:208101 pubmed
    We report single-DNA-stretching experiments showing that the protein Fis, an abundant bacterial chromosome protein of E. coli, mediates a dramatic DNA condensation to zero length...
  10. Galán B, Manso I, Kolb A, Garcia J, Prieto M. The role of FIS protein in the physiological control of the expression of the Escherichia coli meta-hpa operon. Microbiology. 2008;154:2151-60 pubmed publisher
    ..We present in vitro and in vivo studies to demonstrate the involvement of FIS protein in this catabolic repression...
  11. Husnain S, Thomas M. Downregulation of the Escherichia coli guaB promoter by FIS. Microbiology. 2008;154:1729-38 pubmed publisher
    ..Here we investigated the role of the factor for inversion stimulation (FIS) in the regulation of this promoter...
  12. Travers A, Schneider R, Muskhelishvili G. DNA supercoiling and transcription in Escherichia coli: The FIS connection. Biochimie. 2001;83:213-7 pubmed
    The nucleoid-associated protein FIS modulates the topology of DNA in a growth-phase dependent manner functioning homeostatically to counteract excessive levels of negative superhelicity...
  13. Ross W, Thompson J, Newlands J, Gourse R. E.coli Fis protein activates ribosomal RNA transcription in vitro and in vivo. EMBO J. 1990;9:3733-42 pubmed
    ..We have used DNase footprinting to define three specific sites in the rrnB P1 UAR that bind Fis, a protein identified previously by its role in recombinational enhancer function in other systems...
  14. Dennis P, Ehrenberg M, Bremer H. Control of rRNA synthesis in Escherichia coli: a systems biology approach. Microbiol Mol Biol Rev. 2004;68:639-68 pubmed
    ..per minute per promoter in bacterial strains either deficient or proficient in the synthesis of the factor Fis and/or the effector ppGpp...
  15. Dame R. The role of nucleoid-associated proteins in the organization and compaction of bacterial chromatin. Mol Microbiol. 2005;56:858-70 pubmed
    ..Many of these new insights can be attributed to the use of recently developed biophysical techniques. ..
  16. Hirvonen C, Ross W, Wozniak C, Marasco E, Anthony J, Aiyar S, et al. Contributions of UP elements and the transcription factor FIS to expression from the seven rrn P1 promoters in Escherichia coli. J Bacteriol. 2001;183:6305-14 pubmed
    ..Escherichia coli results from a cis-acting DNA sequence, the UP element, and a trans-acting transcription factor, FIS. In this study, we examine the effects of FIS and the UP element at the other six rrn P1 promoters...
  17. Finkel S, Johnson R. The Fis protein: it's not just for DNA inversion anymore. Mol Microbiol. 1992;6:3257-65 pubmed
    ..Examples of this class of proteins are HU, Integration Host Factor, H-NS, and Fis. Fis was originally identified as the factor for inversion stimulation of the homologous Hin and Gin site-specific ..
  18. Squire D, Xu M, Cole J, Busby S, Browning D. Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters. Biochem J. 2009;420:249-57 pubmed publisher
    ..5. NarL-dependent activation at both the yeaR and ogt promoters is decreased in rich medium and this depends on Fis, a nucleoid-associated protein...
  19. Kahramanoglou C, Seshasayee A, Prieto A, Ibberson D, Schmidt S, Zimmermann J, et al. Direct and indirect effects of H-NS and Fis on global gene expression control in Escherichia coli. Nucleic Acids Res. 2011;39:2073-91 pubmed publisher
    ..Two of these--H-NS and Fis--bind to specific DNA sequences and structures...
  20. Hengen P, Bartram S, Stewart L, Schneider T. Information analysis of Fis binding sites. Nucleic Acids Res. 1997;25:4994-5002 pubmed
    Originally discovered in the bacteriophage Mu DNA inversion system gin, Fis (Factor for Inversion Stimulation) regulates many genetic systems...
  21. Falconi M, Brandi A, La Teana A, Gualerzi C, Pon C. Antagonistic involvement of FIS and H-NS proteins in the transcriptional control of hns expression. Mol Microbiol. 1996;19:965-75 pubmed
    Gel shift and DNase I footprinting experiments showed that Escherichia coli FIS (factor for inversion stimulation) protein binds to at least seven sites in the promoter region of hns...
  22. Ohniwa R, Morikawa K, Kim J, Ohta T, Ishihama A, Wada C, et al. Dynamic state of DNA topology is essential for genome condensation in bacteria. EMBO J. 2006;25:5591-602 pubmed
    ..that the expression of Dps and the nucleoid condensation was not simply correlated in Escherichia coli, and that Fis, which is an E...
  23. Lazarus L, Travers A. The Escherichia coli FIS protein is not required for the activation of tyrT transcription on entry into exponential growth. EMBO J. 1993;12:2483-94 pubmed
    The Escherichia coli DNA bending protein factor for inversion stimulation (FIS), is neither necessary nor responsible for the stimulation of transcription from the wild type promoter for the tyrT operon (encoding a species of tyrosine ..
  24. Zimmerman S. Cooperative transitions of isolated Escherichia coli nucleoids: implications for the nucleoid as a cellular phase. J Struct Biol. 2006;153:160-75 pubmed
    ..nor was it changed in nucleoids isolated from cells after exposure to chloramphenicol or from cells in which Dps, Fis, or H-NS and StpA had been deleted...
  25. Azam T, Ishihama A. Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J Biol Chem. 1999;274:33105-13 pubmed
    ..replication origin binding protein), DnaA (DNA-binding protein A), Dps (DNA-binding protein from starved cells), Fis (factor for inversion stimulation), Hfq (host factor for phage Q(beta)), H-NS (histone-like nucleoid structuring ..
  26. Flåtten I, Skarstad K. The Fis protein has a stimulating role in initiation of replication in Escherichia coli in vivo. PLoS ONE. 2013;8:e83562 pubmed publisher
    The Fis protein is a nucleoid associated protein that has previously been reported to act negatively in initiation of replication in Escherichia coli...
  27. Browning D, Grainger D, Beatty C, Wolfe A, Cole J, Busby S. Integration of three signals at the Escherichia coli nrf promoter: a role for Fis protein in catabolite repression. Mol Microbiol. 2005;57:496-510 pubmed
    ..FNR, and by the nitrate/nitrite ion-controlled response regulators, NarL or NarP, but is repressed by the IHF and Fis proteins...
  28. Browning D, Beatty C, Sanstad E, Gunn K, Busby S, Wolfe A. Modulation of CRP-dependent transcription at the Escherichia coli acsP2 promoter by nucleoprotein complexes: anti-activation by the nucleoid proteins FIS and IHF. Mol Microbiol. 2004;51:241-54 pubmed
    ..used electrophoretic mobility shift assays and DNase I footprint analyses to demonstrate that the nucleoid proteins FIS and IHF each bind multiple sites within the acs regulatory region, that FIS competes successfully with CRP for ..
  29. Muskhelishvili G, Travers A, Heumann H, Kahmann R. FIS and RNA polymerase holoenzyme form a specific nucleoprotein complex at a stable RNA promoter. EMBO J. 1995;14:1446-52 pubmed
    The Escherichia coli DNA binding protein FIS activates stable RNA promoters during outgrowth of cells from stationary phase...
  30. Shultzaberger R, Roberts L, Lyakhov I, Sidorov I, Stephen A, Fisher R, et al. Correlation between binding rate constants and individual information of E. coli Fis binding sites. Nucleic Acids Res. 2007;35:5275-83 pubmed
    ..we used surface plasmon resonance and electromobility shift assays to determine the kinetics for binding of the Fis protein to a range of naturally occurring binding sites...
  31. Bradley M, Beach M, De Koning A, Pratt T, Osuna R. Effects of Fis on Escherichia coli gene expression during different growth stages. Microbiology. 2007;153:2922-40 pubmed
    b>Fis is a nucleoid-associated protein in Escherichia coli that is abundant during early exponential growth in rich medium but is in short supply during stationary phase...
  32. Schneider R, Travers A, Kutateladze T, Muskhelishvili G. A DNA architectural protein couples cellular physiology and DNA topology in Escherichia coli. Mol Microbiol. 1999;34:953-64 pubmed
    ..The DNA architectural protein FIS is a regulator of the metabolic reorganization of the cell during early exponential growth phase...
  33. Ali Azam T, Iwata A, Nishimura A, Ueda S, Ishihama A. Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid. J Bacteriol. 1999;181:6361-70 pubmed
    ..as Rob [right origin binding protein]), DnaA (DNA-binding protein A), Dps (DNA-binding protein from starved cells), Fis (factor for inversion stimulation), Hfq (host factor for phage Q(beta)), H-NS (histone-like nucleoid structuring ..
  34. Browning D, Cole J, Busby S. Transcription activation by remodelling of a nucleoprotein assembly: the role of NarL at the FNR-dependent Escherichia coli nir promoter. Mol Microbiol. 2004;53:203-15 pubmed
    ..but that FNR-dependent activation is repressed by IHF binding to a site centred at position -88 (IHF I) and Fis binding to sites centred at positions -142 (Fis I) and +23 (Fis II)...
  35. Bosch L, Nilsson L, Vijgenboom E, Verbeek H. FIS-dependent trans-activation of tRNA and rRNA operons of Escherichia coli. Biochim Biophys Acta. 1990;1050:293-301 pubmed
    ..Both in vivo and in vitro experiments show that the Escherichia coli protein FIS (Factor for Inversion Stimulation) is involved in the trans-activation...
  36. Weinstein Fischer D, Elgrably Weiss M, Altuvia S. Escherichia coli response to hydrogen peroxide: a role for DNA supercoiling, topoisomerase I and Fis. Mol Microbiol. 2000;35:1413-20 pubmed
    ..The peroxide-dependent topA P1 activation is independent of oxyR, but is mediated by Fis. This nucleoid-associated protein binds to the promoter region of topA...
  37. Ryan V, Grimwade J, Camara J, Crooke E, Leonard A. Escherichia coli prereplication complex assembly is regulated by dynamic interplay among Fis, IHF and DnaA. Mol Microbiol. 2004;51:1347-59 pubmed
    Initiator DnaA and DNA bending proteins, Fis and IHF, comprise prereplication complexes (pre-RC) that unwind the Escherichia coli chromosome's origin of replication, oriC...
  38. Filutowicz M, Ross W, Wild J, Gourse R. Involvement of Fis protein in replication of the Escherichia coli chromosome. J Bacteriol. 1992;174:398-407 pubmed
    We report evidence indicating that Fis protein plays a role in initiation of replication at oriC in vivo...
  39. Osuna R, Finkel S, Johnson R. Identification of two functional regions in Fis: the N-terminus is required to promote Hin-mediated DNA inversion but not lambda excision. EMBO J. 1991;10:1593-603 pubmed
    The Fis protein of E. coli binds to a recombinational enhancer sequence that is required to stimulate Hin-mediated DNA inversion. Fis is also required for efficient lambda prophase excision in vivo...
  40. Wold S, Crooke E, Skarstad K. The Escherichia coli Fis protein prevents initiation of DNA replication from oriC in vitro. Nucleic Acids Res. 1996;24:3527-32 pubmed
    b>Fis protein participates in the normal control of chromosomal replication in Escherichia coli. However, the mechanism by which it executes its effect is largely unknown...
  41. Ninnemann O, Koch C, Kahmann R. The E.coli fis promoter is subject to stringent control and autoregulation. EMBO J. 1992;11:1075-83 pubmed
    The DNA binding protein FIS is involved in processes like site specific DNA inversion, lambda excision and stimulation of stable RNA synthesis in Escherichia coli. The amount of FIS protein is subject to dramatic changes during growth...
  42. Miquel S, Claret L, Bonnet R, Dorboz I, Barnich N, Darfeuille Michaud A. Role of decreased levels of Fis histone-like protein in Crohn's disease-associated adherent invasive Escherichia coli LF82 bacteria interacting with intestinal epithelial cells. J Bacteriol. 2010;192:1832-43 pubmed publisher
    ..in AIEC reference strain LF82 during infection of intestinal epithelial cells, Intestine-407, and observed that the fis mRNA level was decreased...
  43. Johnson R, Ball C, Pfeffer D, Simon M. Isolation of the gene encoding the Hin recombinational enhancer binding protein. Proc Natl Acad Sci U S A. 1988;85:3484-8 pubmed
    ..presence of a recombinational enhancer sequence located in cis relative to the recombination sites and a protein, Fis, which binds to the enhancer. We have cloned and determined the primary sequence of the gene encoding Fis...
  44. Caramel A, Schnetz K. Antagonistic control of the Escherichia coli bgl promoter by FIS and CAP in vitro. Mol Microbiol. 2000;36:85-92 pubmed
    ..Here we show that the DNA bending protein FIS is a repressor of the bgl promoter...
  45. Zhi H, Wang X, Cabrera J, Johnson R, Jin D. Fis stabilizes the interaction between RNA polymerase and the ribosomal promoter rrnB P1, leading to transcriptional activation. J Biol Chem. 2003;278:47340-9 pubmed
    It has been shown that Fis activates transcription of the ribosomal promoter rrnB P1; however, the mechanism by which Fis activates rrnB P1 transcription is not fully understood...
  46. Saint Ruf C, Taddei F, Matic I. Stress and survival of aging Escherichia coli rpoS colonies. Genetics. 2004;168:541-6 pubmed
    ..By measuring cell viability and by transcriptome analysis, here we show that rpoS cells as well as wild-type cells survive when they form colonies on solid media. ..
  47. Zhang J, Zeuner Y, Kleefeld A, Unden G, Janshoff A. Multiple site-specific binding of Fis protein to Escherichia coli nuoA-N promoter DNA and its impact on DNA topology visualised by means of scanning force microscopy. Chembiochem. 2004;5:1286-9 pubmed
  48. Augustin L, Jacobson B, Fuchs J. Escherichia coli Fis and DnaA proteins bind specifically to the nrd promoter region and affect expression of an nrd-lac fusion. J Bacteriol. 1994;176:378-87 pubmed
    ..coli factor for inversion stimulation (Fis)...
  49. Hillebrand A, Wurm R, Menzel A, Wagner R. The seven E. coli ribosomal RNA operon upstream regulatory regions differ in structure and transcription factor binding efficiencies. Biol Chem. 2005;386:523-34 pubmed
    ..The different upstream regions were analyzed for their capacity to bind the transcription factors FIS and H-NS, which are known as antagonists in the regulation of rRNA synthesis...
  50. Hansen S, Lewis K, Vulic M. Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrob Agents Chemother. 2008;52:2718-26 pubmed publisher
    ..were dnaJ and dnaK (chaperones), apaH (diadenosine tetraphosphatase), surA (peptidyl-prolyl cis-trans isomerase), fis and hns (global regulators), hnr (response regulator of RpoS), dksA (transcriptional regulator of rRNA ..
  51. Schnetz K. Fine-tuned growth phase control of dps, encoding a DNA protection protein, by FIS and H-NS. Mol Microbiol. 2008;68:1345-7 pubmed publisher
    ..In this issue of Molecular Microbiology, Grainger and co-workers demonstrate that the nucleoid-associated proteins, FIS and H-NS, control sigma factor selection at the dps promoter by a novel mechanism...
  52. Dorman C. Nucleoid-associated proteins and bacterial physiology. Adv Appl Microbiol. 2009;67:47-64 pubmed publisher
    ..The nucleoid-associated proteins, especially Factor for Inversion Stimulation (Fis), IHF, H-NS, HU, and Lrp, represent a prominent group of global regulators and studies of these proteins and their ..
  53. Travers A, Muskhelishvili G. DNA microloops and microdomains: a general mechanism for transcription activation by torsional transmission. J Mol Biol. 1998;279:1027-43 pubmed
    ..However additional functions are suggested by the ability of certain activators, of which FIS is the best characterised example, to facilitate polymerase binding, promoter opening and polymerase escape...
  54. Newlands J, Josaitis C, Ross W, Gourse R. Both fis-dependent and factor-independent upstream activation of the rrnB P1 promoter are face of the helix dependent. Nucleic Acids Res. 1992;20:719-26 pubmed
    ..Activation by the UAR involves two components: (1) a trans-acting protein, Fis, which binds to three sites in the UAR between -60 and -150, and (2) the UAR sequences themselves which affect RNA ..
  55. Zacharias M, Göringer H, Wagner R. Analysis of the Fis-dependent and Fis-independent transcription activation mechanisms of the Escherichia coli ribosomal RNA P1 promoter. Biochemistry. 1992;31:2621-8 pubmed
    ..to activate transcription from P1 in vivo and in vitro and to harbor binding sites for the trans-activating protein Fis. We have constructed a series of linker scanning mutants spanning the region -104 to -47, relative to the ..
  56. Asato Y. Control of ribosome synthesis during the cell division cycles of E. coli and Synechococcus. Curr Issues Mol Biol. 2005;7:109-17 pubmed
    ..UP) element, molecular effectors, ppGpp and iNTP (initiating nucleoside triphosphate), and trans-acting proteins, Fis and H-NS, play important roles in the control of rRNA synthesis in response to changing nutritional environments...
  57. Betermier M, Lefrère V, Koch C, Alazard R, Chandler M. The Escherichia coli protein, Fis: specific binding to the ends of phage Mu DNA and modulation of phage growth. Mol Microbiol. 1989;3:459-68 pubmed
    ..We have identified this protein as Fis, a factor involved in several site-specific recombinational switches...
  58. Kasho K, Fujimitsu K, Matoba T, Oshima T, Katayama T. Timely binding of IHF and Fis to DARS2 regulates ATP-DnaA production and replication initiation. Nucleic Acids Res. 2014;42:13134-49 pubmed publisher
    ..Here, using in vitro reconstituted experiments, we show that two nucleoid-associated proteins, IHF and Fis, bind site-specifically to DARS2 to activate coordinately the exchange reaction...
  59. Spaeny Dekking L, Nilsson L, von Euler A, van de Putte P, Goosen N. Effects of N-terminal deletions of the Escherichia coli protein Fis on growth rate, tRNA(2Ser) expression and cell morphology. Mol Gen Genet. 1995;246:259-65 pubmed
    The Escherichia coli Fis protein is known to be involved in a variety of processes, including the activation of stable RNA operons...
  60. Saldaña Z, Xicohtencatl Cortes J, Avelino F, Phillips A, Kaper J, Puente J, et al. Synergistic role of curli and cellulose in cell adherence and biofilm formation of attaching and effacing Escherichia coli and identification of Fis as a negative regulator of curli. Environ Microbiol. 2009;11:992-1006 pubmed publisher
    ..Analysis of the influence of virulence and global regulators in the production of curli in EPEC identified Fis (factor for inversion stimulation) as a, heretofore unrecognized, negative transcriptional regulator of csgA ..
  61. Neusser T, Gildehaus N, Wurm R, Wagner R. Studies on the expression of 6S RNA from E. coli: involvement of regulators important for stress and growth adaptation. Biol Chem. 2008;389:285-97 pubmed publisher
    ..To this aim, we have analyzed the effects of the typical bacterial growth phase and stress regulators FIS, H-NS, LRP and StpA on 6S RNA expression...
  62. Auner H, Buckle M, Deufel A, Kutateladze T, Lazarus L, Mavathur R, et al. Mechanism of transcriptional activation by FIS: role of core promoter structure and DNA topology. J Mol Biol. 2003;331:331-44 pubmed
    The Escherichia coli DNA architectural protein FIS activates transcription from stable RNA promoters on entry into exponential growth and also reduces the level of negative supercoiling...
  63. Choi H, Kim K, Park J, Jung Y, Lee Y. Effects of FIS protein on rnpB transcription in Escherichia coli. Mol Cells. 2005;19:239-45 pubmed
    Factor for inversion stimulation (FIS), the Escherichia coli protein, is a positive regulator of the transcription of genes that encode stable RNA species, such as rRNA and tRNA...