Gene Symbol: fecD
Description: ferric citrate ABC transporter permease
Alias: ECK4278, JW4248
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Harle C, Kim I, Angerer A, Braun V. Signal transfer through three compartments: transcription initiation of the Escherichia coli ferric citrate transport system from the cell surface. EMBO J. 1995;14:1430-8 pubmed
    ..FecI serves as a sigma factor which facilitates binding of the RNA polymerase to the fec transport gene promoter upstream of fecA.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  2. Veitinger S, Braun V. Localization of the entire fec region at 97.3 minutes on the Escherichia coli K-12 chromosome. J Bacteriol. 1992;174:3838-9 pubmed
  3. Pressler U, Staudenmaier H, Zimmermann L, Braun V. Genetics of the iron dicitrate transport system of Escherichia coli. J Bacteriol. 1988;170:2716-24 pubmed
    ..It was synthesized as a precursor, and the mature form was found in the periplasm. The fecD gene follows fecB and was related to a membrane-bound protein with an apparent molecular weight of 28,000...
  4. Hussein S, Hantke K, Braun V. Citrate-dependent iron transport system in Escherichia coli K-12. Eur J Biochem. 1981;117:431-7 pubmed
    ..The determination of the cotransduction frequencies of Tn10 with the fecA and fecB markers suggested the gene order fecA fecB Tn10. ..
  5. Braun V. Surface signaling: novel transcription initiation mechanism starting from the cell surface. Arch Microbiol. 1997;167:325-31 pubmed
    ..The synthesis of the outer membrane receptor PupB, involved in the transport of the ferric pseudobactins BN7 and BN8, is induced by the ferric siderophores and requires PupB and two proteins homologous to FecI and FecR. ..
  6. Braun V, Mahren S. Transmembrane transcriptional control (surface signalling) of the Escherichia coli Fec type. FEMS Microbiol Rev. 2005;29:673-84 pubmed
    ..avium, and Ralstonia solanacearum. The genomes of P. putida, P. aeruginosa, Nitrosomonas europaea, Bacteroides thetaiotaomicron and Caulobacter crescentus predict the existence of many more such transcriptional regulatory devices. ..
  7. Braun V, Mahren S, Sauter A. Gene regulation by transmembrane signaling. Biometals. 2006;19:103-13 pubmed
    ..Regulation of the fec genes represents the paradigm of a growing number of gene regulation systems involving transmembrane signaling across three cellular compartments. ..
  8. Van Hove B, Staudenmaier H, Braun V. Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12. J Bacteriol. 1990;172:6749-58 pubmed
    ..In the absence of citrate, FecR inactivates FecI. The lack of sequence homologies to other transmembrane signaling proteins and the location of the two proteins suggest a new type of transmembrane control mechanism. ..
  9. Staudenmaier H, Van Hove B, Yaraghi Z, Braun V. Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli. J Bacteriol. 1989;171:2626-33 pubmed
    ..coli K-12 differed in 3 nucleotides, of which 2 gave rise to conservative amino acid exchanges. The fecC and fecD genes were found to encode very hydrophobic polypeptides with molecular weights of 35,367 and 34,148, respectively, ..

More Information


  1. Wagegg W, Braun V. Ferric citrate transport in Escherichia coli requires outer membrane receptor protein fecA. J Bacteriol. 1981;145:156-63 pubmed
    ..E. coli W83-24 and Salmonella typhimurium, which are devoid of a citrate-dependent iron transport system, lacked the FecA protein. It is proposed that the FecA protein participates in the transport of ferric citrate. ..
  2. Sauter A, Braun V. Defined inactive FecA derivatives mutated in functional domains of the outer membrane transport and signaling protein of Escherichia coli K-12. J Bacteriol. 2004;186:5303-10 pubmed
    ..Comparison of the properties of the FecA, FhuA, FepA, and BtuB transporters indicates that although they have very similar crystal structures, the details of their functional mechanisms differ. ..
  3. Braun V, Herrmann C. Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli. J Bacteriol. 2007;189:6913-8 pubmed
    ..by an ABC transporter that consists of the periplasmic binding protein FecB, the transmembrane proteins FecC and FecD, and the ATPase FecE...