fabR

Summary

Gene Symbol: fabR
Description: transcriptional repressor of fabA and fabB
Alias: ECK3955, JW3935, yijC
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Cronan J, Gelmann E. Physical properties of membrane lipids: biological relevance and regulation. Bacteriol Rev. 1975;39:232-56 pubmed
  2. Perez Rueda E, Collado Vides J. The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12. Nucleic Acids Res. 2000;28:1838-47 pubmed
    ..This repertoire should contribute to the interpretation of global gene expression profiles in both prokaryotes and eukaryotes. ..
  3. Marrakchi H, Zhang Y, Rock C. Mechanistic diversity and regulation of Type II fatty acid synthesis. Biochem Soc Trans. 2002;30:1050-5 pubmed
    ..of the interaction between the fatty acid degradation regulator, FadR, and the fatty acid biosynthesis regulator, FabR, in the transcriptional control of unsaturated fatty acid synthesis in Escherichia coli...
  4. Fujita Y, Matsuoka H, Hirooka K. Regulation of fatty acid metabolism in bacteria. Mol Microbiol. 2007;66:829-39 pubmed
    ..regulation of the biosynthesis of unsaturated fatty acids in a concerted manner with negative regulation of FabR. On the other hand, Bacillus subtilis possesses two global transcriptional regulators, FadR (YsiA) and FapR. B...
  5. Gustafsson C, Warne S. Physical map of the oxyR-trmA region (minute 89.3) of the Escherichia coli chromosome. J Bacteriol. 1992;174:7878-9 pubmed
  6. Bateman A, Birney E, Durbin R, Eddy S, Howe K, Sonnhammer E. The Pfam protein families database. Nucleic Acids Res. 2000;28:263-6 pubmed
    ..These Pfam families match 63% of proteins in SWISS-PROT 37 and TrEMBL 9. For complete genomes Pfam currently matches up to half of the proteins. Genomic DNA can be directly searched against the Pfam library using the Wise2 package. ..
  7. McCue L, Thompson W, Carmack C, Ryan M, Liu J, Derbyshire V, et al. Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes. Nucleic Acids Res. 2001;29:774-82 pubmed
    ..included bona fide TF-binding sites was proven by affinity purification of a putative transcription factor (YijC) bound to such a site upstream of the fabA gene. Predicted regulatory sites for 2097 E...
  8. Ramos J, Martínez Bueno M, Molina Henares A, Teran W, Watanabe K, Zhang X, et al. The TetR family of transcriptional repressors. Microbiol Mol Biol Rev. 2005;69:326-56 pubmed
    ..Information related to the TetR family of regulators has been updated in a database that can be accessed at www.bactregulators.org. ..
  9. White S, Zheng J, Zhang Y, Rock -. The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem. 2005;74:791-831 pubmed
    ..These structures are also a valuable resource to guide antibacterial drug discovery. ..

More Information

Publications13

  1. Zhang Y, Rock C. Transcriptional regulation in bacterial membrane lipid synthesis. J Lipid Res. 2009;50 Suppl:S115-9 pubmed publisher
  2. Zhang Y, Marrakchi H, Rock C. The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli. J Biol Chem. 2002;277:15558-65 pubmed
    ..This study links the FabR (YijC) transcription factor to the regulation of unsaturated fatty acid content through the regulation of fabB gene ..
  3. Zhang Y, Marrakchi H, White S, Rock C. The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. J Lipid Res. 2003;44:1-10 pubmed
    ..Computational methods facilitated the discovery of the E. coli fatty acid synthesis transcriptional regulator, FabR, and led to the identification of novel bacterial FAS II proteins in Gram-positive pathogens, including enoyl-ACP ..
  4. Zhu K, Zhang Y, Rock C. Transcriptional regulation of membrane lipid homeostasis in Escherichia coli. J Biol Chem. 2009;284:34880-8 pubmed publisher
    ..The FabR (fatty acid biosynthesis repressor) transcriptional repressor controls the proportion of unsaturated fatty acids in ..