Gene Symbol: endA
Description: DNA-specific endonuclease I
Alias: ECK2940, JW2912
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Wright M, Buttin G, Hurwitz J. The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes. J Biol Chem. 1971;246:6543-55 pubmed
  2. Wright M. Mutants of Escherichia coli lacking endonuclease I, ribonuclease I, or ribonuclease II. J Bacteriol. 1971;107:87-94 pubmed
    ..Most end mutations, called endA, are also cotransducible with serA and are located between serA and strA...
  3. Ehrlich S, Bertazzoni U, Bernardi G. The specificity of Escherichia coli endonuclease I. Eur J Biochem. 1973;40:149-53 pubmed
  4. Melgar E, Goldthwait D. Deoxyribonucleic acid nucleases. I. The use of a new method to observe the kinetics of deoxyribonucleic acid degradation by deoxyribonuclease I, deoxyribonuclease II, and Escherichia coli endonuclease I. J Biol Chem. 1968;243:4401-8 pubmed
  5. Goebel W, Helinski D. Nicking activity of an endonuclease. I. Transfer ribonucleic acid complex of Escherichia coli. Biochemistry. 1970;9:4793-801 pubmed
  6. Jekel M, Wackernagel W. The periplasmic endonuclease I of Escherichia coli has amino-acid sequence homology to the extracellular DNases of Vibrio cholerae and Aeromonas hydrophila. Gene. 1995;154:55-9 pubmed
    The gene endA, encoding the periplasmic endonuclease I (EndoI) of Escherichia coli, was identified on a cloned chromosomal 1.5-kb HindIII fragment...
  7. Jekel M, Wackernagel W. Location of the endA gene coding for endonuclease I on the physical map of the Escherichia coli K-12 chromosome. J Bacteriol. 1994;176:1550-1 pubmed
  8. Griffith M, Gietz R. Escherichia coli endA deletion strain for use in two-hybrid shuttle vector selection. Biotechniques. 2003;35:272-4, 276, 278 pubmed
  9. Lehman I, Roussos G, Pratt E. The deoxyribo-nucleases of Escherichia coli. III. Studies on the nature of the inhibition of endonuclease by ribonucleic acid. J Biol Chem. 1962;237:829-33 pubmed

More Information


  1. Lehman I, Roussos G, Pratt E. The deoxyribonucleases of Escherichia coli. II. Purification and properties of a ribonucleic acid-inhibitable endonuclease. J Biol Chem. 1962;237:819-28 pubmed
  3. D├╝rwald H, Hoffmann Berling H. Endonuclease-I-deficient and ribonuclease I-deficient Escherichia coli mutants. J Mol Biol. 1968;34:331-46 pubmed
  4. Cordonnier C, Bernardi G. Localization of E. coli endonuclease I. Biochem Biophys Res Commun. 1965;20:555-9 pubmed
  5. Zabel D, Trucksis M, Depew R. Salmonella typhimurium mutants with reduced levels of transfer ribonucleic acid-inhibitable endodeoxyribonucleolytic activity. J Bacteriol. 1980;144:173-8 pubmed
    ..The chemically induced mutations defined a locus, endA, which was cotransduced with serA at a low frequency and with metK at a high frequency...
  6. Vertommen D, Depuydt M, Pan J, Leverrier P, Knoops L, Szikora J, et al. The disulphide isomerase DsbC cooperates with the oxidase DsbA in a DsbD-independent manner. Mol Microbiol. 2008;67:336-49 pubmed
    ..Our data indicate that DsbC can assist DsbA in a DsbD-independent manner to oxidatively fold envelope proteins. The view that DsbC's function is limited to the disulphide isomerization pathway should therefore be reinterpreted. ..