Gene Symbol: emrY
Description: putative multidrug efflux system
Alias: ECK2363, JW2364
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Paulsen I, Brown M, Skurray R. Proton-dependent multidrug efflux systems. Microbiol Rev. 1996;60:575-608 pubmed
  2. Han X, Dorsey Oresto A, Malik M, Wang J, Drlica K, Zhao X, et al. Escherichia coli genes that reduce the lethal effects of stress. BMC Microbiol. 2010;10:35 pubmed publisher
    ..The gene set, which differed from sets previously identified with bacteriostatic assays, provides an entry point for obtaining small-molecule enhancers that will affect multiple antimicrobial agents. ..
  3. Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R. Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12. Biosci Biotechnol Biochem. 2000;64:1203-9 pubmed
    ..Furthermore, the start site of transcription from the promoter of emrKY was identified; EvgA was shown to bind at the -52 to -84 region by the footprinting experiment. ..
  4. Tanabe H, Yamasak K, Furue M, Yamamoto K, Katoh A, Yamamoto M, et al. Growth phase-dependent transcription of emrKY, a homolog of multidrug efflux emrAB genes of Escherichia coli, is induced by tetracycline. J Gen Appl Microbiol. 1997;43:257-263 pubmed
    The genes emrK and emrY were found between genes dsdA and evgA at 51 min on the Escherichia coli chromosome and form an operon. EmrK and EmrY are 50.4 and 63...
  5. Salmon K, Hung S, Mekjian K, Baldi P, Hatfield G, Gunsalus R. Global gene expression profiling in Escherichia coli K12. The effects of oxygen availability and FNR. J Biol Chem. 2003;278:29837-55 pubmed
    ..In particular, we describe an approach for identifying gene expression patterns (clusters) obtained from multiple perturbation experiments based on a subset of genes that exhibit high probability for differential expression values. ..
  6. Eguchi Y, Oshima T, Mori H, Aono R, Yamamoto K, Ishihama A, et al. Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli. Microbiology. 2003;149:2819-28 pubmed
    ..Taken together we propose that the expression of the MDR system is under a complex regulatory network, including the phosphorylated EvgA serving as the master regulator. ..
  7. Nishino K, Yamaguchi A. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. J Bacteriol. 2004;186:1423-9 pubmed
    ..Double deletion of the mdtEF and acrEF genes completely suppressed Deltahns-mediated multidrug resistance, indicating that Deltahns-mediated multidrug resistance is due to derepression of the acrEF and mdtEF drug exporter genes. ..
  8. Kobayashi A, Hirakawa H, Hirata T, Nishino K, Yamaguchi A. Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. J Bacteriol. 2006;188:5693-703 pubmed
    ..The induction level was decreased by tnaAB deletion, suggesting that indole sensing stimulates this process. ..
  9. Nishino K, Yamaguchi A. Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. J Bacteriol. 2001;183:1455-8 pubmed
    ..Since overexpression of the emrKY operon, which is controlled by evgAS, could account only for deoxycholate resistance, the evgAS locus apparently controls expression of at least one other multidrug efflux operon. ..

More Information


  1. Yamada S, Awano N, Inubushi K, Maeda E, Nakamori S, Nishino K, et al. Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Appl Environ Microbiol. 2006;72:4735-42 pubmed
    ..These results indicate that the multidrug transporter Bcr in the major facilitator family is involved in L-cysteine export and overproduction in genetically engineered E. coli cells. ..