Gene Symbol: efeO
Description: inactive ferrous ion transporter EfeUOB
Alias: ECK1008, JW1003, ycdO
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Sturm A, Schierhorn A, Lindenstrauss U, Lilie H, Brüser T. YcdB from Escherichia coli reveals a novel class of Tat-dependently translocated hemoproteins. J Biol Chem. 2006;281:13972-8 pubmed
    ..in the reasons for the Tat dependence of novel Tat substrates and focused on two uncharacterized proteins, YcdO and YcdB. Both proteins contain predicted Tat signal sequences...
  2. Maurer L, Yohannes E, Bondurant S, Radmacher M, Slonczewski J. pH regulates genes for flagellar motility, catabolism, and oxidative stress in Escherichia coli K-12. J Bacteriol. 2005;187:304-19 pubmed
  3. Cao J, Woodhall M, Alvarez J, Cartron M, Andrews S. EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7. Mol Microbiol. 2007;65:857-75 pubmed
    ..EfeU is homologous to the high-affinity iron permease, Ftr1p, of Saccharomyces cerevisiae and other fungi. EfeO is periplasmic with a cupredoxin N-terminal domain; EfeB is also periplasmic and is haem peroxidase-like...
  4. Kang Y, Weber K, Qiu Y, Kiley P, Blattner F. Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown function. J Bacteriol. 2005;187:1135-60 pubmed publisher
    ..We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized...
  5. Massé E, Vanderpool C, Gottesman S. Effect of RyhB small RNA on global iron use in Escherichia coli. J Bacteriol. 2005;187:6962-71 pubmed
    ..Our results demonstrate the broad effects of a single noncoding RNA on iron homeostasis. ..
  6. Wang L, Li J, March J, Valdes J, Bentley W. luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling. J Bacteriol. 2005;187:8350-60 pubmed
    ..These data are consistent with the function of LuxS as an important metabolic enzyme but appear not to support the role of AI-2 as a true signal molecule for E. coli W3110 under the investigated conditions. ..
  7. DeVito J, Mills J, Liu V, Agarwal A, Sizemore C, Yao Z, et al. An array of target-specific screening strains for antibacterial discovery. Nat Biotechnol. 2002;20:478-83 pubmed
    ..As an example of the target specificity of the approach, compounds identified in the whole-cell screen for MurA inhibitors were also found to block the biochemical function of the target when tested in vitro. ..
  8. Weber A, Jung K. Profiling early osmostress-dependent gene expression in Escherichia coli using DNA macroarrays. J Bacteriol. 2002;184:5502-7 pubmed
    ..Northern blot analysis of several selected genes differing in their relative expression values confirmed the results obtained by the array technology. ..
  9. Prüss B, Campbell J, Van Dyk T, Zhu C, Kogan Y, Matsumura P. FlhD/FlhC is a regulator of anaerobic respiration and the Entner-Doudoroff pathway through induction of the methyl-accepting chemotaxis protein Aer. J Bacteriol. 2003;185:534-43 pubmed
    ..Growth phenotypes of flhD and flhC mutants were determined with Phenotype MicroArrays and correlated with gene expression. ..

More Information


  1. Rajasekaran M, Nilapwar S, Andrews S, Watson K. EfeO-cupredoxins: major new members of the cupredoxin superfamily with roles in bacterial iron transport. Biometals. 2010;23:1-17 pubmed publisher
    ..b>EfeO and EfeB are periplasmic but their precise roles are unclear...
  2. McHugh J, Rodríguez Quiñones F, Abdul Tehrani H, Svistunenko D, Poole R, Cooper C, et al. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. J Biol Chem. 2003;278:29478-86 pubmed
    ..In combination, the results provide compelling evidence for the regulation of intracellular iron consumption by the Fe2+-Fur complex. ..
  3. Ren D, Bedzyk L, Ye R, Thomas S, Wood T. Stationary-phase quorum-sensing signals affect autoinducer-2 and gene expression in Escherichia coli. Appl Environ Microbiol. 2004;70:2038-43 pubmed
    ..coli K-12 AI-2 concentrations by 4.8-fold +/- 0.4-fold, suggesting that an additional quorum-sensing system in E. coli exists and that gene expression is controlled as a network with different signals working at different growth stages. ..
  4. Grosse C, Scherer J, Koch D, Otto M, Taudte N, Grass G. A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia coli. Mol Microbiol. 2006;62:120-31 pubmed
    ..In vitro the EfeU variant protein with an altered first REGLE motif was impaired in iron permeation, whereas activity of the EfeU variant with a mutation in the second motif was similar to the wild-type protein. ..
  5. Graubner W, Schierhorn A, Brüser T. DnaK plays a pivotal role in Tat targeting of CueO and functions beside SlyD as a general Tat signal binding chaperone. J Biol Chem. 2007;282:7116-24 pubmed
    ..The overall results suggest that SlyD and DnaK are in the set of chaperones that can serve as general Tat signal-binding proteins. DnaK has additional functions that are indispensable for the targeting of CueO. ..
  6. Han X, Dorsey Oresto A, Malik M, Wang J, Drlica K, Zhao X, et al. Escherichia coli genes that reduce the lethal effects of stress. BMC Microbiol. 2010;10:35 pubmed publisher
    ..The gene set, which differed from sets previously identified with bacteriostatic assays, provides an entry point for obtaining small-molecule enhancers that will affect multiple antimicrobial agents. ..