Gene Symbol: efeB
Description: deferrrochelatase, periplasmic
Alias: ECK1009, JW1004, ycdB
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Kim S, Makino K, Amemura M, Shinagawa H, Nakata A. Molecular analysis of the phoH gene, belonging to the phosphate regulon in Escherichia coli. J Bacteriol. 1993;175:1316-24 pubmed
    ..Transcription from the P1 promoter required the phoB function and was induced by phosphate limitation, while transcription from the P2 promoter was independent of phoB and constitutive under tested conditions. ..
  2. Graubner W, Schierhorn A, Brüser T. DnaK plays a pivotal role in Tat targeting of CueO and functions beside SlyD as a general Tat signal binding chaperone. J Biol Chem. 2007;282:7116-24 pubmed
    ..Deletion of dnaK completely abolished Tat-dependent translocation of CueO, but not of DmsA, YcdB, or HiPIP, indicating that DnaK has an essential role specifically for CueO...
  3. Sasarman A, Surdeanu M, Szegli G, Horodniceanu T, Greceanu V, Dumitrescu A. Hemin-deficient mutants of Escherichia coli K-12. J Bacteriol. 1968;96:570-2 pubmed
  4. McHugh J, Rodríguez Quiñones F, Abdul Tehrani H, Svistunenko D, Poole R, Cooper C, et al. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. J Biol Chem. 2003;278:29478-86 pubmed
    ..In combination, the results provide compelling evidence for the regulation of intracellular iron consumption by the Fe2+-Fur complex. ..
  5. Létoffé S, Heuck G, Delepelaire P, Lange N, Wandersman C. Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact. Proc Natl Acad Sci U S A. 2009;106:11719-24 pubmed publisher
    ..Here, we identified 2 Escherichia coli paralogs, YfeX and EfeB, without any previously known physiological functions...
  6. Cao J, Woodhall M, Alvarez J, Cartron M, Andrews S. EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7. Mol Microbiol. 2007;65:857-75 pubmed
    ..EfeO is periplasmic with a cupredoxin N-terminal domain; EfeB is also periplasmic and is haem peroxidase-like. All three Efe proteins are required for Efe function...
  7. Grosse C, Scherer J, Koch D, Otto M, Taudte N, Grass G. A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia coli. Mol Microbiol. 2006;62:120-31 pubmed
    ..In vitro the EfeU variant protein with an altered first REGLE motif was impaired in iron permeation, whereas activity of the EfeU variant with a mutation in the second motif was similar to the wild-type protein. ..
  8. Massé E, Vanderpool C, Gottesman S. Effect of RyhB small RNA on global iron use in Escherichia coli. J Bacteriol. 2005;187:6962-71 pubmed
    ..Our results demonstrate the broad effects of a single noncoding RNA on iron homeostasis. ..
  9. Maurer L, Yohannes E, Bondurant S, Radmacher M, Slonczewski J. pH regulates genes for flagellar motility, catabolism, and oxidative stress in Escherichia coli K-12. J Bacteriol. 2005;187:304-19 pubmed

More Information


  1. Kang Y, Weber K, Qiu Y, Kiley P, Blattner F. Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown function. J Bacteriol. 2005;187:1135-60 pubmed publisher
    ..We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized...
  2. Ren D, Bedzyk L, Ye R, Thomas S, Wood T. Stationary-phase quorum-sensing signals affect autoinducer-2 and gene expression in Escherichia coli. Appl Environ Microbiol. 2004;70:2038-43 pubmed
    ..coli K-12 AI-2 concentrations by 4.8-fold +/- 0.4-fold, suggesting that an additional quorum-sensing system in E. coli exists and that gene expression is controlled as a network with different signals working at different growth stages. ..
  3. McConville M, Charles H. Mutants of Escherichia coli K12 permeable to haemin. J Gen Microbiol. 1979;113:165-8 pubmed
    ..Indirect evidence is presented that the mutants were permeable to haemin. The mutants showed other phenotypic changes, and resembled some mutants which are known to have changes in the cell envelope. ..
  4. Wang L, Li J, March J, Valdes J, Bentley W. luxS-dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling. J Bacteriol. 2005;187:8350-60 pubmed
    ..These data are consistent with the function of LuxS as an important metabolic enzyme but appear not to support the role of AI-2 as a true signal molecule for E. coli W3110 under the investigated conditions. ..
  5. Sturm A, Schierhorn A, Lindenstrauss U, Lilie H, Brüser T. YcdB from Escherichia coli reveals a novel class of Tat-dependently translocated hemoproteins. J Biol Chem. 2006;281:13972-8 pubmed
    ..in the reasons for the Tat dependence of novel Tat substrates and focused on two uncharacterized proteins, YcdO and YcdB. Both proteins contain predicted Tat signal sequences...
  6. Cartron M, Mitchell S, Woodhall M, Andrews S, Watson K. Preliminary X-ray diffraction analysis of YcdB from Escherichia coli: a novel haem-containing and Tat-secreted periplasmic protein with a potential role in iron transport. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:37-41 pubmed
    b>YcdB is a periplasmic haem-containing protein from Escherichia coli that has a potential role in iron transport. It is currently the only reported haem-containing Tat-secreted substrate...
  7. Prüss B, Campbell J, Van Dyk T, Zhu C, Kogan Y, Matsumura P. FlhD/FlhC is a regulator of anaerobic respiration and the Entner-Doudoroff pathway through induction of the methyl-accepting chemotaxis protein Aer. J Bacteriol. 2003;185:534-43 pubmed
    ..Growth phenotypes of flhD and flhC mutants were determined with Phenotype MicroArrays and correlated with gene expression. ..
  8. Weber A, Jung K. Profiling early osmostress-dependent gene expression in Escherichia coli using DNA macroarrays. J Bacteriol. 2002;184:5502-7 pubmed
    ..Northern blot analysis of several selected genes differing in their relative expression values confirmed the results obtained by the array technology. ..