Gene Symbol: ECs4491
Description: hypothetical protein
Species: Escherichia coli O157:H7 str. Sakai

Top Publications

  1. Klein J, Plapp R. Locations of the envCD genes on the physical map of the Escherichia coli chromosome. J Bacteriol. 1992;174:3828-9 pubmed
  2. Klein J, Henrich B, Plapp R. Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. Mol Gen Genet. 1991;230:230-40 pubmed
    ..Overproduction of EnvC protein appears to be lethal to Escherichia coli. The envD gene, however, could be cloned and expressed at high levels under control of the tac promoter without deleterious effects on the host. ..
  3. Michel G, Di Savino D, Starka J. Phospholipid composition and phenotypic correction of an envC division mutant of Escherichia coli. J Bacteriol. 1977;129:145-50 pubmed
    ..Thus, the increase of external osmolarity acts on phospholipid metabolism as well as on an unknown step involved in the mechanism of cell division of the envC mutant. ..
  4. Saier M, Tam R, Reizer A, Reizer J. Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol Microbiol. 1994;11:841-7 pubmed
    ..We propose that an MFP functions co-operatively with an RND protein to transport large or hydrophobic molecules across the two membranes of the Gram-negative bacterial cell envelope. ..
  5. Ma D, Cook D, Alberti M, Pon N, Nikaido H, Hearst J. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J Bacteriol. 1993;175:6299-313 pubmed
    ..coli polypeptides, EnvC and EnvD, respectively. Drug susceptibilities in one acrA mutant (N43) and one envCD mutant (PM61) have been determined and compared. Finally, the possible functions of these proteins are discussed. ..
  6. Michel G. The changes in cell size and phospholipid composition during growth of a chain-forming envC mutant of Escherichia coli. FEBS Lett. 1979;100:258-60 pubmed
  7. Rodolakis A, Thomas P, Starka J. Morphological mutants of Escherichia coli. Isolation and ultrastructure of a chain-forming envC mutant. J Gen Microbiol. 1973;75:409-16 pubmed
  8. Michel G, Karibian D, Bonnaveiro N, Starka J. Is there a correlation between membrane phospholipid metabolism and cell division?. Ann Inst Pasteur Microbiol (1985). 1985;136A:111-8 pubmed
    ..Future work will show how all these correlations function on the genetic and molecular levels. ..
  9. Karibian D, Pellon G, Starka J. Autolysis of a division mutant of Escherichia coli. J Gen Microbiol. 1981;126:55-61 pubmed
    ..The results suggest that the triggering of autolysis in E. coli envC depends on the alteration of envelope constituents rather than on an enhanced activity of murein hydrolases. ..

More Information


  1. Starkova Z, Thomas P, Starka J. Morphological mutants of Escherichia coli: nature of the permeability barrier in mon and envC cells. Ann Microbiol (Paris). 1978;129:265-84 pubmed
    ..The mutant envC is sensitive to actinomycin D and to rifampicin, is lysed by lysozyme in the absence of EDTA, and releases alkaline phosphatase in the absence of osomotic shock, indicating a gross perturbation of its outer membrane. ..
  2. Hara H, Narita S, Karibian D, Park J, Yamamoto Y, Nishimura Y. Identification and characterization of the Escherichia coli envC gene encoding a periplasmic coiled-coil protein with putative peptidase activity. FEMS Microbiol Lett. 2002;212:229-36 pubmed
    ..Disruption of the chromosomal envC caused the same defects as the envC point mutation, indicating the gene is dispensable for growth but important for normal septation/separation and cell envelope integrity...
  3. Starka J, Di Savino D, Michel G, Rodolakis A, Thomas P. Phenotypic expression of an envC-division mutant of Escherichia coli K12. Ann Microbiol (Paris). 1974;125 B:227-32 pubmed
  4. Seiffer D, Klein J, Plapp R. EnvC, a new lipoprotein of the cytoplasmic membrane of Escherichia coli. FEMS Microbiol Lett. 1993;107:175-8 pubmed
    ..This protein was not labelled with [3H]glycerol. The results demonstrate that the envC gene product represents a new lipoprotein of the cytoplasmic membrane of E. coli. ..
  5. Ichimura T, Yamazoe M, Maeda M, Wada C, Hiraga S. Proteolytic activity of YibP protein in Escherichia coli. J Bacteriol. 2002;184:2595-602 pubmed
    ..Results suggest that the coiled-coil regions and the C-terminal globular domain of YibP are localized in the cytoplasmic space, not in the periplasmic space. Purified YibP has a protease activity that split the substrate beta-casein...
  6. Michel G, Starka J. Origin and fate of the lysophosphatidylethanolamine in a chain-forming mutant (envC) of Escherichia coli. J Gen Microbiol. 1984;130:1391-8 pubmed
    ..These results indicate the existence of a deacylation-reacylation cycle in E. coli and show that this cycle is perturbed in envC cells, especially at the lysophospholipase step. ..