Gene Symbol: ECs4132
Description: tRNA-dihydrouridine synthase B
Species: Escherichia coli O157:H7 str. Sakai
Ninnemann O, Koch C, Kahmann R. The E.coli fis promoter is subject to stringent control and autoregulation. EMBO J. 1992;11:1075-83 pubmed
..We show that the fis promoter is subject to stringent control and discuss this unusual feature with respect to the known and putative functions FIS serves in E. coli. ..
Johnson R, Ball C, Pfeffer D, Simon M. Isolation of the gene encoding the Hin recombinational enhancer binding protein. Proc Natl Acad Sci U S A. 1988;85:3484-8 pubmed
..coli that lack a functional fis gene demonstrates that Fis is not essential for cell growth under laboratory conditions but is required for high rates of Hin-mediated site-specific inversion in vivo. ..
Morett E, Bork P. Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC. FEBS Lett. 1998;433:108-12 pubmed
..Thus, we propose that yhdG and fis were acquired by a lineage ancestral to the gamma proteobacteria in a single horizontal gene transfer event, and later diverged to their present functions. ..
Koch C, Vandekerckhove J, Kahmann R. Escherichia coli host factor for site-specific DNA inversion: cloning and characterization of the fis gene. Proc Natl Acad Sci U S A. 1988;85:4237-41 pubmed
..Fis is nonessential for Es. coli growth; however, inversion of the G segment of a Mu prophage was not detected in the fis mutant. The fis gene is located between 71 and 72 min on the Es. coli genetic map. ..
Bishop A, Xu J, Johnson R, Schimmel P, de Cr cy Lagard V. Identification of the tRNA-dihydrouridine synthase family. J Biol Chem. 2002;277:25090-5 pubmed publisher
..coli. They also suggest that the COG0042-encoded family members act site-specifically on the tRNA D-loop and contain non-redundant catalytic functions in vivo...
Ball C, Osuna R, Ferguson K, Johnson R. Dramatic changes in Fis levels upon nutrient upshift in Escherichia coli. J Bacteriol. 1992;174:8043-56 pubmed
..We suggest that the fluctuations in Fis levels may serve as an early signal of a nutritional upshift and may be important in the physiological roles Fis plays in the cell. ..
Vanet A, Plumbridge J, Alix J. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. J Bacteriol. 1993;175:7178-88 pubmed
..Although no promoter activity was detected immediately upstream of prmA, S1 mapping detected 5' ends of mRNA in this region, implying that some mRNA processing occurs within the bicistronic panF-prmA mRNA. ..