Genomes and Genes
Gene Symbol: ECs3395
Description: scaffold protein
Species: Escherichia coli O157:H7 str. Sakai
- Nuth M, Yoon T, Cowan J. Iron-sulfur cluster biosynthesis: characterization of iron nucleation sites for assembly of the [2Fe-2S]2+ cluster core in IscU proteins. J Am Chem Soc. 2002;124:8774-5 pubmed..The latter observation reflects the low binding affinity of persulfido IscU for iron ion...
- Frazzon J, Fick J, Dean D. Biosynthesis of iron-sulphur clusters is a complex and highly conserved process. Biochem Soc Trans. 2002;30:680-5 pubmed
- Nakamura M, Saeki K, Takahashi Y. Hyperproduction of recombinant ferredoxins in escherichia coli by coexpression of the ORF1-ORF2-iscS-iscU-iscA-hscB-hs cA-fdx-ORF3 gene cluster. J Biochem. 1999;126:10-8 pubmed..These results indicate that the proteins encoded by the gene cluster are involved in the assembly of the Fe-S clusters in a wide variety of Fe-S proteins. ..
- Kato S, Mihara H, Kurihara T, Takahashi Y, Tokumoto U, Yoshimura T, et al. Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: implications for the mechanism of iron-sulfur cluster assembly. Proc Natl Acad Sci U S A. 2002;99:5948-52 pubmed publisher
- Smith A, Agar J, Johnson K, Frazzon J, Amster I, Dean D, et al. Sulfur transfer from IscS to IscU: the first step in iron-sulfur cluster biosynthesis. J Am Chem Soc. 2001;123:11103-4 pubmed
- Kurihara T, Mihara H, Kato S, Yoshimura T, Esaki N. Assembly of iron-sulfur clusters mediated by cysteine desulfurases, IscS, CsdB and CSD, from Escherichia coli. Biochim Biophys Acta. 2003;1647:303-9 pubmed
- Zheng L, Cash V, Flint D, Dean D. Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii. J Biol Chem. 1998;273:13264-72 pubmed..These results show that the cysE-like gene located upstream from iscS is not essential for cell growth and that the cysE-like gene and the iscSUA-hscBA-fdx genes are contained within separate transcription units. ..